MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1575 to 1624 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
788	transformer-2 protein homolog (tra-2 alpha). [swissprot;acc:q13595]	Subtracted	6472.38	7092.65	620.27
	vacuolar proton translocating atpase 116 kda subunit a isoform 3 (v- atpase 116-kda isoform a3) (osteoclastic proton pump 116 kda subunit) (oc-116 kda) (oc116) (t-cell immune regulator 1) (t cell immune response cdna7 protein) (tirc7). [swissprot;acc:q13488]	Divided	5890.41	6547.81	1.11161
789	atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632]		5890.59	6547.99	1.1116
	importin beta-3 subunit (karyopherin beta-3 subunit) (ran-binding protein 5). [swissprot;acc:o00410]	Subtracted	6167.33	6785.98	618.65
790	ran-gtp binding protein (fragment). [sptrembl;acc:o60518]		6165.1	6783.01	617.91
	vacuolar proton translocating atpase 116 kda subunit a isoform 1 (clathrin-coated vesicle/synaptic vesicle proton pump 116 kda subunit) (vacuolar proton pump subunit 1) (vacuolar adenosine triphosphatase subunit ac116). [swissprot;acc:q93050]	Divided	5890.88	6548.28	1.1116
791	monoglyceride lipase; lysophospholipase-like. [refseq;acc:nm_007283]	Subtracted	6544.26	7159.43	615.17
	transducin beta-like 3; wd-repeat protein sazd. [refseq;acc:nm_006453]	Divided	4025.3	4474.3	1.11154
792	axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645]		6772.75	7526.2	1.11125
	target of myb protein 1. [swissprot;acc:o60784]	Subtracted	5640.79	6255.85	615.06
793	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]		5641.11	6255.99	614.88
	putative n6-dna-methyltransferase (ec 2.1.1.-) (protein pred28) (m.hsahemk2p). [swissprot;acc:q9y5n5]	Divided	5036.92	5596.36	1.11107
794	dna topoisomerase ii, alpha isozyme (ec 5.99.1.3). [swissprot;acc:p11388]		6441.17	7154.55	1.11075
	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	Subtracted	5641.12	6255.99	614.87
795	dna topoisomerase ii, beta isozyme (ec 5.99.1.3). [swissprot;acc:q02880]	Divided	6441.14	7154.13	1.11069
	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	Subtracted	5641.53	6256.17	614.64
796	integral membrane protein 2b (transmembrane protein bri) [contains: abri/adan amyloid peptide]. [swissprot;acc:q9y287]		6362.64	6976.1	613.46
	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	Divided	6834.54	7590.49	1.11061
797	importin beta-1 subunit (karyopherin beta-1 subunit) (nuclear factor p97) (importin 90). [swissprot;acc:q14974]
	integral membrane protein 2c (transmembrane protein bri3) (npd018). [swissprot;acc:q9nqx7]	Subtracted	6362.64	6976.1	613.46
798	integral membrane protein 2a (e25 protein). [swissprot;acc:o43736]
	transducin beta-like 1x protein (transducin-beta-like 1, x-linked). [swissprot;acc:o60907]	Divided	6834.54	7590.49	1.11061
799	dihydropyrimidine dehydrogenase [nadp+] precursor (ec 1.3.1.2) (dpd) (dhpdhase) (dihydrouracil dehydrogenase) (dihydrothymine dehydrogenase). [swissprot;acc:q12882]	Subtracted	5222.71	5834.57	611.86
	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	Divided	6834.54	7590.49	1.11061
800	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	Subtracted	3583.56	4194.95	611.39
	orphan nuclear receptor nr6a1 (germ cell nuclear factor) (gcnf) (retinoid receptor-related testis specific receptor) (rtr). [swissprot;acc:q15406]	Divided	6075.55	6746.92	1.1105
801	importin alpha-3 subunit (karyopherin alpha-3 subunit) (srp1-gamma). [swissprot;acc:o00505]		6456.35	7169.75
	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	Subtracted	779.167	1390.33	611.163
802	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]
	target of egr1, member 1 (nuclear); target of egr1, member 1. [refseq;acc:nm_025077]	Divided	6455.66	7168.82	1.11047
803	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	Subtracted	779.167	1390.33	611.163
	importin alpha-4 subunit (karyopherin alpha-4 subunit) (qip1 protein). [swissprot;acc:o00629]	Divided	6455.02	7167.96	1.11045
804	nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9]		6770.78	7517.97	1.11036
	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	Subtracted	779.167	1390.33	611.163
805	60s ribosomal protein l39. [swissprot;acc:p02404]	Divided	4708.61	5226.71	1.11003
	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	Subtracted	779.167	1390.33	611.163
806	60s ribosomal protein l18a. [swissprot;acc:q02543]	Divided	4708.61	5226.71	1.11003
	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]	Subtracted	779.167	1390.33	611.163
807	40s ribosomal protein s19. [swissprot;acc:p39019]	Divided	4708.61	5226.71	1.11003
	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	Subtracted	779.167	1390.33	611.163
808	60s ribosomal protein l31. [swissprot;acc:p12947]	Divided	4708.61	5226.71	1.11003
	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	Subtracted	779.167	1390.33	611.163
809	protein kinase clk2 (ec 2.7.1.-) (cdc-like kinase 2). [swissprot;acc:p49760]		6435.94	7045.75	609.81
	wd-repeat protein 3. [swissprot;acc:q9unx4]	Divided	4039.81	4484.22	1.11001
810	jm1 protein. [refseq;acc:nm_014008]		5794.8	6427.79	1.10923
	protein kinase clk3 (ec 2.7.1.-) (cdc-like kinase 3). [swissprot;acc:p49761]	Subtracted	6435.02	7044.65	609.63
811	adiponectin receptor 2. [refseq;acc:nm_024551]		3153.1	3762.56	609.46
	atp synthase delta chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p30049]	Divided	6000.07	6655.11	1.10917
812	puromycin-sensitive aminopeptidase (ec 3.4.11.-) (psa). [swissprot;acc:p55786]	Subtracted	5745.61	6354.75	609.14
	target of myb protein 1. [swissprot;acc:o60784]	Divided	5640.79	6255.85	1.10904

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.