MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Value Type	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1075 to 1124 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
269	Squared	thymic stromal co-transporter. [refseq;acc:nm_033051]	26157.6	20236.2	1.29261
	Rooted	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	66.1064	74.1074	1.12103
270	Measured	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	23640.2	19479.8	1.21358
	Ranked	fad synthetase. [refseq;acc:nm_025207]	241.373	267.352	1.10763
	Squared	transcription factor iib. [refseq;acc:nm_013242]	64739.9	50300.6	1.28706
	Rooted	crk-like protein. [swissprot;acc:p46109]	66.1064	74.1074	1.12103
271	Measured	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	2554.89	3093.78	1.21092
	Ranked	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	241.373	267.352	1.10763
	Squared	splicing factor, arginine/serine-rich 8 (suppressor of white apricot protein homolog). [swissprot;acc:q12872]	64739.9	50300.6	1.28706
	Rooted	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	66.1064	74.1073	1.12103
272	Measured	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	3858.52	4669.27	1.21012
	Ranked	ligatin (hepatocellular carcinoma-associated antigen 56). [swissprot;acc:p41214]	241.373	267.352	1.10763
	Squared	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]	36563.7	46971.1	1.28464
	Rooted	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	66.1064	74.1074	1.12103
273	Measured	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	3199.4	3870.8	1.20985
	Ranked	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1 (paps synthethase 1) (papss 1) (sulfurylase kinase 1) (sk1) (sk 1) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o43252]	241.373	267.352	1.10763
	Squared	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	16120.1	20665.7	1.28198
	Rooted	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	66.1064	74.1074	1.12103
274	Measured	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	3119.98	2579.49	1.20953
	Ranked	nadph-cytochrome p450 reductase (ec 1.6.2.4) (cpr) (p450r). [swissprot;acc:p16435]	241.373	267.352	1.10763
	Squared	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	16120.1	20665.7	1.28198
	Rooted	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	66.1063	74.1068	1.12102
275	Measured	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	3119.98	2579.49	1.20953
	Ranked	cholinephosphate cytidylyltransferase b (ec 2.7.7.15) (phosphorylcholine transferase b) (ctp:phosphocholine cytidylyltransferase b) (ct b) (cct b) (cct-beta). [swissprot;acc:q9y5k3]	241.373	267.352	1.10763
	Squared	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	16120.1	20665.7	1.28198
	Rooted	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	66.1048	74.0977	1.12091
276	Measured	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	3119.98	2579.49	1.20953
	Ranked	60s ribosomal protein l32. [swissprot;acc:p02433]	241.13	266.969	1.10716
	Squared	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	16120.1	20665.7	1.28198
	Rooted	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	66.1046	74.0964	1.1209
277	Measured	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	3119.98	2579.49	1.20953
	Ranked	40s ribosomal protein s29. [swissprot;acc:p30054]	241.849	267.642	1.10665
	Squared	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	16120.1	20665.7	1.28198
	Rooted	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	65.9938	73.9449	1.12048
278	Measured	transcription factor lbx1. [swissprot;acc:p52954]	3119.98	2579.49	1.20953
	Ranked	40s ribosomal protein s11. [swissprot;acc:p04643]	241.399	267.088	1.10642
	Squared	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	16120.1	20665.7	1.28198
	Rooted	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	65.9938	73.9449	1.12048
279	Measured	mosaic protein lgn. [swissprot;acc:p81274]	3119.98	2579.49	1.20953
	Ranked	histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	252.644	228.42	1.10605
	Squared	musashi 2 isoform a. [refseq;acc:nm_138962]	15569.5	19953.6	1.28158
	Rooted	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	66.0989	74.0609	1.12046
280	Measured	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	3119.98	2579.49	1.20953
	Ranked	metastasis-associated protein mta1. [swissprot;acc:q13330]	252.512	228.356	1.10578
	Squared	musashi 1. [refseq;acc:nm_002442]	15569.5	19953.6	1.28158
	Rooted	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	57.9068	64.8562	1.12001
281	Measured	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	3119.98	2579.49	1.20953
	Ranked	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	241.808	267.335	1.10557
	Squared	nuclear protein ukp68. [refseq;acc:nm_024824]	15569.5	19953.6	1.28158
	Rooted	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	57.9068	64.8562	1.12001

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.