MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	Hugo	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 143 to 192 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	Hugo	description	red	green	network_comparison
36	Squared	PANK1	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	106226	192141	1.80879
	Rooted	GNAZ	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	40.2805	24.369	1.65294
37	Measured	GNAT1	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	1836.76	907.763	2.02339
	Ranked	PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	322	253	1.27273
	Squared	PANK2	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	106226	192141	1.80879
	Rooted	GNAT1	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	40.2805	24.3691	1.65293
38	Measured	GNAT2	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	1836.76	907.774	2.02337
	Ranked	MFAP4	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	322	253	1.27273
	Squared	PANK3	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	106226	192141	1.80879
	Rooted	GNAT2	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	40.2804	24.3692	1.65292
39	Measured	GNAI2	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	1836.8	907.903	2.02312
	Ranked	PPP1R14D	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	322	253	1.27273
	Squared	SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	106226	192141	1.80879
	Rooted	GNAI2	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	40.28	24.37	1.65285
40	Measured	GNAI1	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	1836.81	907.978	2.02297
	Ranked	FCN2	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	322	253	1.27273
	Squared	ATG4A	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	144940	81169.7	1.78564
	Rooted	GNAI1	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	40.2797	24.3705	1.65281
41	Measured	GNAI3	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	1836.81	907.978	2.02297
	Ranked	no value	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	322	253	1.27273
	Squared	MAP1LC3B	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	144912	81155	1.78562
	Rooted	GNAI3	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	40.2797	24.3705	1.65281
42	Measured	GNB5	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	1857.32	958.237	1.93827
	Ranked	FOS	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	204.641	160.957	1.2714
	Squared	MAP1LC3A	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	144911	81154.7	1.78561
	Rooted	GNB5	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	40.225	24.7051	1.62821
43	Measured	GNB3	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	1881.02	1027.36	1.83093
	Ranked	no value	jun dimerization protein. [refseq;acc:nm_130469]	204.641	160.957	1.2714
	Squared	ATG4B	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	144876	81136.5	1.78558
	Rooted	GNB1	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	40.6302	25.4452	1.59677
44	Measured			1931.34	1057.39	1.82652
	Ranked	FOSL2	fos-related antigen 2. [swissprot;acc:p15408]	204.641	161.046	1.2707
	Squared	GABARAP	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	139741	78454.6	1.78117
	Rooted	GNB4	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	40.5691	25.4263	1.59556
45	Measured			1926.69	1056.02	1.82448
	Ranked	FOSB	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	204.641	161.051	1.27066
	Squared	no value	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	129597	73157.5	1.77148
	Rooted	GNB3	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	40.081	25.1546	1.59339
46	Measured	NEUROD2	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	779.167	1390.33	1.78438
	Ranked	FOSL1	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	204.642	161.068	1.27053
	Squared	ATG3	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	129597	73157.5	1.77148
	Rooted	DTX2	deltex 2. [refseq;acc:nm_020892]	27.634	43.9629	1.5909
47	Measured	CHD3	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	779.167	1390.33	1.78438
	Ranked	TMEM132A	gbp protein isoform a. [refseq;acc:nm_017870]	325.586	256.492	1.26938
	Squared	no value	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	98517.9	56927.2	1.73059
	Rooted	DTX1	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	27.7078	44.017	1.58861
48	Measured	CDK2AP2	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	779.167	1390.33	1.78438
	Ranked	GABARAP	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	65.4586	83.0461	1.26868
	Squared	LASS2	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	6300.2	10703.5	1.69891
	Rooted	PBK	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	27.7254	44.0299	1.58807

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.