MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	Filtered	description	Network Comparison Type	Interaction Map	green	network_comparison	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 3730 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	Filtered	description	green	network_comparison	red
1	0	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	15915	3.70633	4294
	1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	24	2.4	10
2	0	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	14977	2.55362	5865
	1	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	28	1.86667	15
3	0	nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]	11083.9	2.47638	4475.84
	1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	28	1.86667	15
4	0	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	21883	2.45711	8906
	1	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	28	1.86667	15
5	0	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	11965.7	2.17144	5510.5
	1	cytohesin 4. [swissprot;acc:q9uia0]	28	1.86667	15
6	0	ubiquitin protein ligase. [refseq;acc:nm_130466]	15339.2	2.03897	7523
	1	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	28	1.86667	15
7	0	cab2. [refseq;acc:nm_033419]	10950	1.99689	21866
	1	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	322	1.49767	215
8	0	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	21888	1.89918	11525
	1	hbs1-like. [refseq;acc:nm_006620]	322	1.49767	215
9	0	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	21888	1.89918	11525
	1	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	309	1.45755	212
10	0	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	14178.1	1.88805	7509.39
	1	protein x 0004. [refseq;acc:nm_016301]	309	1.45755	212
11	0	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	6248	1.86092	11627
	1	rad50-interacting protein 1. [refseq;acc:nm_021930]	232	1.45259	337
12	0	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	5208.84	1.81023	9429.18
	1	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	232	1.45259	337
13	0	heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107]	9264.5	1.77804	5210.5
	1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	212.554	1.3585	288.754
14	0	dystrophin. [swissprot;acc:p11532]	18054.8	1.76446	10232.5
	1	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	75.3531	1.32952	56.6768
15	0	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	11267	1.72211	19403
	1	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	75.3948	1.32914	56.7244
16	0	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]	20670.6	1.69839	12170.7
	1	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	75.3954	1.32913	56.7252
17	0	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	6812	1.69451	11543
	1	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	75.447	1.32866	56.7841
18	0	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	13216	1.68629	22286
	1	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	245.247	1.32082	185.678
19	0	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	13216	1.68629	22286
	1	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	245.247	1.32082	185.678
20	0	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	13216	1.68629	22286
	1	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	245.247	1.32082	185.678
21	0	acrc protein; putative nuclear protein. [refseq;acc:nm_052957]	10621.4	1.68236	6313.38
	1	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	245.247	1.32082	185.678
22	0	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	12479	1.68195	20989
	1	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	245.247	1.32082	185.678
23	0	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]	9285.44	1.67148	15520.4
	1	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	44	1.31818	58
24	0	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	8257	1.66289	13730.5
	1	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	44	1.31818	58
25	0	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	8257	1.66289	13730.5
	1	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	44	1.31818	58

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.