MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Rank	Gene	Value Type	description	Interaction Map	Hugo	network_comparison	Filtered	red	green

Results: HTML CSV LaTeX

Showing element 258 to 307 of 66312 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Value Type	description	Interaction Map	Hugo	network_comparison	red	green
33	Measured	vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]	Low confidence	BEST2	1.19275	36360.3	43368.8
	Ranked	dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985]		MAP2K4	1.17068	210.241	246.125
		serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	High confidence	PPP2R1B	1.28647	188.688	242.742
	Squared	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Low confidence	no value	1.33073	82347.8	61881.5
		spermatogenesis associated 6. [refseq;acc:nm_019073]	High confidence	SPATA6	2.53372	9924.76	25146.6
	Rooted	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]		no value	1.65937	26.0288	43.1914
		retinoblastoma-associated factor 600. [refseq;acc:nm_020765]	Low confidence	UBR4	1.15738	76.5734	88.6244
34	Measured	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	High confidence	GNA11	2.02382	1836.71	907.546
		protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Low confidence	UFC1	1.1897	5339.5	6352.4
	Ranked	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		UBAC1	1.16197	155.56	133.876
		serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	High confidence	PPP2R1A	1.28235	189.07	242.453
	Squared	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]		AMPD2	2.53372	9924.76	25146.6
		melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Low confidence	MAGEA6	1.33073	82347.8	61881.5
	Rooted	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	High confidence	GNA11	1.65305	40.2812	24.3678
		putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	Low confidence	RBM7	1.15698	49.0544	56.755
35	Measured	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]		DNASE2B	1.18866	33111.4	39358.1
		guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	High confidence	GNAQ	2.02378	1836.71	907.564
	Ranked	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]		NFYC	1.27519	260.532	204.309
		tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Low confidence	TOB2	1.14959	297.273	258.59
	Squared	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	High confidence	MRPS17	1.80879	106226	192141
		necdin. [swissprot;acc:q99608]	Low confidence	NDN	1.33073	82347.8	61881.5
	Rooted	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	High confidence	GNAQ	1.65304	40.2812	24.3679
		regulator of g-protein signaling 12 (rgs12). [swissprot;acc:o14924]	Low confidence	RGS12	1.15329	54.8296	63.2347
36	Measured	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	High confidence	GNAZ	2.02344	1836.76	907.741
		proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Low confidence	FOS	1.17513	6462.09	7593.77
	Ranked	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	High confidence	NFYA	1.27519	260.532	204.309
		tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Low confidence	TOB1	1.14906	296.837	258.33
	Squared	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]		MAGED1	1.33073	82347.8	61881.5
		pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	High confidence	PANK1	1.80879	106226	192141
	Rooted	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	Low confidence	CHRAC1	1.15273	55.7086	64.217
		guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	High confidence	GNAZ	1.65294	40.2805	24.369
37	Measured	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]		GNAT1	2.02339	1836.76	907.763
		jun dimerization protein. [refseq;acc:nm_130469]	Low confidence	no value	1.17513	6462.09	7593.77
	Ranked	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]		CHRAC1	1.14874	250.244	217.843
		protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	High confidence	PPP1R14A	1.27273	322	253
	Squared	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Low confidence	MAGEF1	1.33073	82347.8	61881.5
		pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	High confidence	PANK2	1.80879	106226	192141
	Rooted	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]		GNAT1	1.65293	40.2805	24.3691
		testis-specific protein tex28. [swissprot;acc:o15482]	Low confidence	TEX28P2	1.14428	51.7058	59.166
38	Measured	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	High confidence	GNAT2	2.02337	1836.76	907.774
		rab11-family interacting protein 4. [refseq;acc:nm_032932]	Low confidence	RAB11FIP4	1.17403	7407.56	8696.7
	Ranked	glucosamine-6-phosphate isomerase. [refseq;acc:nm_138335]		GNPDA2	1.14456	247.202	282.937
		microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	High confidence	MFAP4	1.27273	322	253
	Squared	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Low confidence	MAGEB6B	1.33073	82347.8	61881.5
		pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	High confidence	PANK3	1.80879	106226	192141
	Rooted	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	Low confidence	GOSR2	1.14428	51.7058	59.166
		guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	High confidence	GNAT2	1.65292	40.2804	24.3692
39	Measured	eferin. [swissprot;acc:o75154]	Low confidence	RAB11FIP3	1.17403	7407.56	8696.7
		guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	High confidence	GNAI2	2.02312	1836.8	907.903
	Ranked	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	Low confidence	GNPDA1	1.14456	247.202	282.937

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.