MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2051 to 2100 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	network_comparison	green
1026	hydroxyacid oxidase 1 (ec 1.1.3.15) (haox1) (glycolate oxidase) (gox). [swissprot;acc:q9ujm8]	HAO1	Subtracted	231.922	6.564	238.486
	transforming protein rhoa (h12). [swissprot;acc:p06749]	RHOA	Divided	205.632	1.03195	199.266
1027	adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741]	no value	Subtracted	211.449	6.549	217.998
	succinyl-coa ligase [gdp-forming] alpha-chain, mitochondrial precursor (ec 6.2.1.4) (succinyl-coa synthetase, alpha chain) (scs-alpha). [swissprot;acc:p53597]	SUCLG1	Divided	211.908	1.03171	218.627
1028	estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061]	HSD17B1	Subtracted	211.449	6.549	217.998
	succinyl-coa ligase [adp-forming] beta-chain, mitochondrial precursor (ec 6.2.1.5) (succinyl-coa synthetase, betaa chain) (scs-betaa) (atp- specific succinyl-coa synthetase beta subunit). [swissprot;acc:q9p2r7]	SUCLA2	Divided	211.908	1.03171	218.627
1029	17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	no value	Subtracted	211.449	6.549	217.998
	dna damage binding protein 1 (damage-specific dna binding protein 1) (ddb p127 subunit) (ddba) (uv-damaged dna-binding protein 1) (uv-ddb 1) (xeroderma pigmentosum group e complementing protein) (xpce) (x- associated protein 1) (xap-1). [swissprot;acc:q16531]	DDB1	Divided	222.364	1.03168	215.535
1030	propionyl-coa carboxylase beta chain, mitochondrial precursor (ec 6.4.1.3) (pccase beta subunit) (propanoyl-coa:carbon dioxide ligase beta subunit). [swissprot;acc:p05166]	PCCB
	retinol dehydrogenase 8 (all-trans); photoreceptor outer segment all-trans retinol dehydrogenase. [refseq;acc:nm_015725]	RDH8	Subtracted	211.449	6.549	217.998
1031	hcv ns3-transactivated protein 1. [refseq;acc:nm_019048]	ASNSD1		219.01	6.542	212.468
	probable ribosome biogenesis protein nep1 (c2f protein). [swissprot;acc:q92979]	EMG1	Divided	242.978	1.03167	235.518
1032	1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	AGPAT2		186.664	1.03162	180.943
	vacuolar atp synthase catalytic subunit a, ubiquitous isoform (ec 3.6.3.14) (v-atpase a subunit 1) (vacuolar proton pump alpha subunit 1) (v-atpase 69 kda subunit 1) (isoform va68). [swissprot;acc:p38606]	ATP6V1A	Subtracted	219.01	6.542	212.468
1033	asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243]	ASNS
	tyrosinase precursor (ec 1.14.18.1) (monophenol monooxygenase) (tumor rejection antigen ab) (sk29-ab) (lb24-ab). [swissprot;acc:p14679]	TYR	Divided	221.183	1.03161	214.406
1034	40s ribosomal protein s27 (metallopan-stimulin 1) (mps-1). [swissprot;acc:p42677]	no value	Subtracted	229.442	6.532	235.974
	steroid hormone receptor err2 (estrogen-related receptor, beta) (err-beta) (estrogen receptor-like 2) (err beta-2). [swissprot;acc:o95718]	ESRRB	Divided	186.551	1.0316	180.837
1035	atrophin-1 interacting protein 1; activin receptor interacting protein 1; likely ortholog of mouse activin receptor interacting protein 1; atrophin-1 interacting protein a; membrane associated guanylate kinase 2; activin receptor interacting p. [refseq;acc:nm_012301]	MAGI2		221.682	1.03157	228.68
	ribosomal protein s27-like protein; 40s ribosomal protein s27 isoform. [refseq;acc:nm_015920]	RPS27L	Subtracted	229.441	6.531	235.972
1036	coatomer beta subunit (beta-coat protein) (beta-cop). [swissprot;acc:p53618]	COPB1	Divided	171.341	1.03155	176.746
	dihydrolipoamide dehydrogenase, mitochondrial precursor (ec 1.8.1.4) (glycine cleavage system l protein). [swissprot;acc:p09622]	DLD	Subtracted	207.719	6.517	214.236
1037	nemo-like kinase; likely ortholog of mouse nemo like kinase. [refseq;acc:nm_016231]	NLK		218.162	6.514	211.648
	thioredoxin-like; pkc-interacting cousin of thioredoxin. [refseq;acc:nm_006541]	GLRX3	Divided	228.412	1.03151	235.609
1038	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	no value		186.741	1.03148	181.041
	elks protein. [refseq;acc:nm_015064]	ERC1	Subtracted	218.162	6.514	211.648
1039	dihydrolipoamide dehydrogenase, mitochondrial precursor (ec 1.8.1.4) (glycine cleavage system l protein). [swissprot;acc:p09622]	DLD	Divided	207.719	1.03137	214.236
	phafin 2; ph and fyve domain-containing protein 2. [refseq;acc:nm_024613]	PLEKHF2	Subtracted	220.118	6.433	213.685
1040	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	SRD5A1
	t-complex protein 1, epsilon subunit (tcp-1-epsilon) (cct-epsilon). [swissprot;acc:p48643]	CCT5	Divided	163.24	1.03136	168.359
1041	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	SRD5A2	Subtracted	220.118	6.433	213.685
	heterogeneous nuclear ribonucleoprotein l (hnrnp l). [swissprot;acc:p14866]	HNRNPL	Divided	186.774	1.03134	181.099
1042	estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454]	no value		186.799	1.03132	181.127
	ww domain binding protein 2 (wbp-2). [swissprot;acc:q969t9]	WBP2	Subtracted	216.901	6.416	210.485
1043	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	AGPAT3	Divided	187.834	1.03128	182.137
	nucleolar protein nop5 (nucleolar protein 5) (nop58) (hspc120). [swissprot;acc:q9y2x3]	no value	Subtracted	239.219	6.382	232.837
1044	activator of camp-responsive element modulator (crem) in testis; lim protein act. [refseq;acc:nm_020482]	FHL5		269.157	6.374	275.531
	t-complex associated-testis-expressed 1-like (protein 91/23). [swissprot;acc:p51808]	DYNLT3	Divided	173.475	1.03121	178.889
1045	cystathionine beta-synthase (ec 4.2.1.22) (serine sulfhydrase) (beta-thionase). [swissprot;acc:p35520]	CBS	Subtracted	205.632	6.366	199.266
	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	FIP1L1	Divided	115.817	1.03121	119.432
1046	double-strand break repair protein mre11a (mre11 homolog 1). [swissprot;acc:p49959]	MRE11A		173.475		178.889
	transforming protein rhoc (h9). [swissprot;acc:p08134]	RHOC	Subtracted	205.632	6.366	199.266
1047	steroid hormone receptor err1 (estrogen-related receptor, alpha) (err-alpha) (estrogen receptor-like 1). [swissprot;acc:p11474]	ESRRA	Divided	187.022	1.03104	181.391
	thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [swissprot;acc:q16762]	TST	Subtracted	205.632	6.366	199.266
1048	1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	AGPAT4	Divided	187.96	1.031	182.308
	3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	MPST	Subtracted	205.632	6.366	199.266
1049	adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741]	no value	Divided	211.449	1.03097	217.998
	transforming protein rhoa (h12). [swissprot;acc:p06749]	RHOA	Subtracted	205.632	6.366	199.266
1050	bystin. [swissprot;acc:q13895]	BYSL		239.505	6.32	233.185
	estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061]	HSD17B1	Divided	211.449	1.03097	217.998

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.