MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1093 to 1142 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
547	ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	Subtracted	6228.39	7013.19	784.8
	werner helicase interacting protein isoform 1; putative helicase ruvbl; werner helicase interacting protein. [refseq;acc:nm_020135]	Divided	5291.92	6020.19	1.13762
548	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]		8268.19	9405.85	1.13759
	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	Subtracted	6228.39	7013.19	784.8
549	dolichol-phosphate mannosyltransferase (ec 2.4.1.83) (dolichol- phosphate mannose synthase) (dolichyl-phosphate beta-d- mannosyltransferase) (mannose-p-dolichol synthase) (mpd synthase) (dpm synthase). [swissprot;acc:o60762]	Divided	5865.79	6671.23	1.13731
	mitochondrial ferritin; ferritin heavy chain-like; ferritin h subunit. [refseq;acc:nm_177478]	Subtracted	6228.42	7013.21	784.79
550	ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]		6228.97	7013.53	784.56
	prohibitin. [swissprot;acc:p35232]	Divided	5773.45	6563.69	1.13687
551	adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]	Subtracted	6503.1	7282.94	779.84
	repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273]	Divided	5773.45	6563.69	1.13687
552	adenylosuccinate synthetase (ec 6.3.4.4) (imp--aspartate ligase) (adss) (ampsase). [swissprot;acc:p30520]	Subtracted	6503.03	7282.5	779.47
	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	Divided	15427.2	13572.8	1.13663
553	coatomer beta subunit (beta-coat protein) (beta-cop). [swissprot;acc:p53618]	Subtracted	10430.3	9656.4	773.9
	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]	Divided	3853.64	4379.71	1.13651
554	dendritic cell protein. [refseq;acc:nm_006360]	Subtracted	6593.17	7364.55	771.38
	pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]	Divided	14830.5	13050.3	1.13641
555	potential carboxypeptidase-like protein x2 precursor. [swissprot;acc:q8n436]	Subtracted	6593.17	7364.55	771.38
	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	Divided	6167.93	7007.7	1.13615
556	carboxypeptidase n catalytic chain precursor (ec 3.4.17.3) (arginine carboxypeptidase) (kininase 1) (serum carboxypeptidase n) (scpn) (anaphylatoxin inactivator) (plasma carboxypeptidase b). [swissprot;acc:p15169]	Subtracted	6593.17	7364.55	771.38
	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	Divided	6167.93	7007.7	1.13615
557	cpz gene product. [refseq;acc:nm_003652]	Subtracted	6593.17	7364.55	771.38
	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]	Divided	6167.93	7007.7	1.13615
558	carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870]	Subtracted	6593.17	7364.55	771.38
	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	Divided	6167.93	7007.7	1.13615
559	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]
	potential carboxypeptidase x precursor (ec 3.4.17.-) (metallocarboxypeptidase cpx-1). [swissprot;acc:q96sm3]	Subtracted	6593.17	7364.55	771.38
560	cystathionine beta-synthase (ec 4.2.1.22) (serine sulfhydrase) (beta-thionase). [swissprot;acc:p35520]	Divided	5480.24	6222.04	1.13536
	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]	Subtracted	6374.65	7145.59	770.94
561	transforming protein rhoc (h9). [swissprot;acc:p08134]	Divided	5480.24	6222.04	1.13536
	tubby protein homolog. [swissprot;acc:p50607]	Subtracted	6374.65	7145.59	770.94
562	protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]
	thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [swissprot;acc:q16762]	Divided	5480.24	6222.04	1.13536
563	3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]
	numb protein homolog (h-numb) (protein s171). [swissprot;acc:p49757]	Subtracted	6374.65	7145.59	770.94
564	tbc1 domain family member 5. [swissprot;acc:q92609]
	transforming protein rhoa (h12). [swissprot;acc:p06749]	Divided	5480.24	6222.04	1.13536
565	small glutamine-rich tetratricopeptide repeat-containing protein (vpu-binding protein) (ubp). [swissprot;acc:o43765]		10434.4	11846.2	1.1353
	tubby related protein 1 (tubby-like protein 1). [swissprot;acc:o00294]	Subtracted	6374.65	7145.59	770.94
566	autoantigen ngp-1. [swissprot;acc:q13823]	Divided	3766.14	4274.79	1.13506
	vacuolar protein sorting 29 (vesicle protein sorting 29) (hvps29) (mds007) (pep11) (dc7/dc15). [swissprot;acc:q9ubq0]	Subtracted	6374.65	7145.59	770.94
567	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (ec 3.6.1.23) (dutpase) (dutp pyrophosphatase). [swissprot;acc:p33316]	Divided	10264.9	9043.51	1.13506
	numb-like protein (numb-r). [swissprot;acc:q9y6r0]	Subtracted	6374.65	7145.59	770.94
568	grpe protein homolog 2, mitochondrial precursor (mt-grpe#2). [swissprot;acc:q8taa5]	Divided	4134.77	4691.24	1.13458
	tubby related protein 3 (tubby-like protein 3). [swissprot;acc:o75386]	Subtracted	6374.65	7145.59	770.94
569	grpe protein homolog 1, mitochondrial precursor (mt-grpe#1) (hmge). [swissprot;acc:q9hav7]	Divided	4134.77	4691.24	1.13458
	vacuolar protein sorting 35 (vesicle protein sorting 35) (hvps35) (maternal-embryonic 3). [swissprot;acc:q96qk1]	Subtracted	6374.65	7145.59	770.94
570	protein kinase c, zeta type (ec 2.7.1.37) (npkc-zeta). [swissprot;acc:q05513]
	swi/snf-related matrix-associated actin-dependent regulator of chromatin d2; rsc6p; mammalian chromatin remodeling complex brg1-associated factor 60b; swp73-like protein; chromatin remodeling complex baf60b subunit; swi/snf complex 60 kda subunit b. [refseq;acc:nm_003077]	Divided	4134.77	4691.24	1.13458
571	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	Subtracted	3856.29	4624.15	767.86
	swi/snf-related matrix-associated actin-dependent regulator of chromatin d3; rsc6p; mammalian chromatin remodeling complex brg1-associated factor 60c; swp73-like protein; chromatin remodeling complex baf60c subunit; swi/snf complex 60 kda subunit c. [refseq;acc:nm_003078]	Divided	4134.77	4691.24	1.13458

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.