MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Network Comparison Type	Value Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1077 to 1126 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
539	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	Subtracted	126	112	14
	protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]	Divided	252.86	236.964	1.06708
540	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	Subtracted	44	58	14
	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	Divided	208.201	222.156	1.06703
541	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]
	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Subtracted	126	112	14
542	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]	Divided	208.201	222.156	1.06703
	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Subtracted	126	112	14
543	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]
	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	Divided	208.201	222.156	1.06703
544	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	Subtracted	126	112	14
	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]	Divided	208.201	222.156	1.06703
545	eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]		233.287	248.866	1.06678
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Subtracted	44	58	14
546	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]		126	112
	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	Divided	194.262	207.222	1.06671
547	alanyl-trna synthetase (ec 6.1.1.7) (alanine--trna ligase) (alars). [swissprot;acc:p49588]	Subtracted	248.104	234.106	13.998
	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	Divided	194.346	207.26	1.06645
548	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	Subtracted	208.201	222.156	13.955
	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]	Divided	194.346	207.26	1.06645
549	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	Subtracted	208.201	222.156	13.955
	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	Divided	194.346	207.26	1.06645
550	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]	Subtracted	208.201	222.156	13.955
	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	Divided	194.346	207.26	1.06645
551	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]		194.347	207.261
	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	Subtracted	208.201	222.156	13.955
552	crk-like protein. [swissprot;acc:p46109]	Divided	194.346	207.26	1.06645
	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]	Subtracted	208.201	222.156	13.955
553	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	Divided	194.346	207.26	1.06645
	putative pre-mrna splicing factor rna helicase (atp-dependent rna helicase #3) (deah-box protein 16). [swissprot;acc:o60231]	Subtracted	212.38	226.3	13.92
554	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	Divided	194.346	207.26	1.06645
	t54 protein. [swissprot;acc:q92917]	Subtracted	212.38	226.3	13.92
555	cbf1 interacting corepressor. [refseq;acc:nm_004882]		213.945	227.86	13.915
	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	Divided	194.346	207.26	1.06645
556	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]		194.368	207.27	1.06638
	evolutionarily conserved g-patch domain containing. [refseq;acc:nm_018025]	Subtracted	213.945	227.86	13.915
557	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	Divided	194.371	207.272	1.06637
	shwachman-bodian-diamond syndrome protein (cgi-97). [swissprot;acc:q9y3a5]	Subtracted	230.362	216.557	13.805
558	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]		235.255	248.994	13.739
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	Divided	144.041	135.087	1.06628
559	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]		194.452	207.309	1.06612
	ribonuclease p protein subunit p30 (ec 3.1.26.5) (rnasep protein p30) (rnase p subunit 2). [swissprot;acc:p78346]	Subtracted	230.439	216.72	13.719
560	son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	Divided	193.021	205.74	1.06589
	tata-binding protein-associated phosphoprotein (down-regulator of transcription 1) (dr1 protein). [swissprot;acc:q01658]	Subtracted	218.406	232.118	13.712
561	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]	Divided	193.183	205.89	1.06578
	u6 snrna-associated sm-like protein lsm2 (small nuclear ribonuclear protein d homolog) (g7b) (snrnp core sm-like protein sm-x5). [swissprot;acc:q9y333]	Subtracted	214.546	228.215	13.669
562	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]		210.944	224.606	13.662
	ptb domain adaptor protein ced-6; engulfment adapter protein. [refseq;acc:nm_016315]	Divided	207.121	220.744	1.06577
563	calcyphosine. [swissprot;acc:q13938]
	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	Subtracted	210.944	224.606	13.662

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.