MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1058 to 1107 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
529	mitochondrial processing peptidase alpha subunit, mitochondrial precursor (ec 3.4.24.64) (alpha-mpp) (p-55) (ha1523). [swissprot;acc:q10713]	Subtracted	5244.88	6036.38	791.5
530	peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855]	Divided	8600.02	9792.49	1.13866
	ubiquinol-cytochrome c reductase complex core protein i, mitochondrial precursor (ec 1.10.2.2). [swissprot;acc:p31930]	Subtracted	5246.38	6037.37	790.99
531	prohibitin. [swissprot;acc:p35232]		5773.45	6563.69	790.24
	transcription initiation factor iib (general transcription factor tfiib) (s300-ii). [swissprot;acc:q00403]	Divided	4651.88	5296.78	1.13863
532	repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273]	Subtracted	5773.45	6563.69	790.24
	thyroid receptor interacting protein 3 (trip-3) (fragment). [swissprot;acc:q15649]	Divided	4651.88	5296.78	1.13863
533	epoxide hydrolase 1 (ec 3.3.2.3) (microsomal epoxide hydrolase) (epoxide hydratase). [swissprot;acc:p07099]	Subtracted	11785.4	10995.3	790.1
	nhp2-like protein 1 (high mobility group-like nuclear protein 2 homolog 1) ([u4/u6.u5] tri-snrnp 15.5 kda protein) (otk27). [swissprot;acc:p55769]	Divided	4651.88	5296.78	1.13863
534	nuclear fragile x mental retardation protein interacting protein 1; nuclear fragile x mental retardation intercating protein 1; nuclear fragile x mental retardation protein-interacting protein 1. [refseq;acc:nm_012345]
	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	Subtracted	5233.86	6022.6	788.74
535	translocon-associated protein, delta subunit precursor (trap-delta) (signal sequence receptor delta subunit) (ssr-delta). [swissprot;acc:p51571]	Divided	10603.5	12069.5	1.13826
	vinculin (metavinculin). [swissprot;acc:p18206]	Subtracted	5958.23	6743.37	785.14
536	calsyntenin-1 precursor. [swissprot;acc:o94985]	Divided	10603.5	12069.5	1.13826
	ferritin heavy chain (ferritin h subunit). [swissprot;acc:p02794]	Subtracted	6227.87	7012.9	785.03
537	cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]		6228.39	7013.19	784.8
	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	Divided	10603.5	12069.5	1.13826
538	dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6]	Subtracted	6228.39	7013.19	784.8
	protein-tyrosine phosphatase beta precursor (ec 3.1.3.48) (r-ptp- beta). [swissprot;acc:p23467]	Divided	10603.5	12069.4	1.13825
539	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	Subtracted	6228.39	7013.19	784.8
	thymus-specific serine protease precursor (ec 3.4.-.-). [swissprot;acc:q9nqe7]	Divided	10603.5	12069.4	1.13825
540	gk001 protein. [refseq;acc:nm_020198]
	putative adenosylhomocysteinase 2 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:o43865]	Subtracted	6228.39	7013.19	784.8
541	calsyntenin-2 precursor. [swissprot;acc:q9h4d0]	Divided	10600.3	12065.2	1.13819
	limkain b1. [refseq;acc:nm_019081]	Subtracted	6228.39	7013.19	784.8
542	putative adenosylhomocysteinase 3 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:q96hn2]
	rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]	Divided	3889.27	4426.74	1.13819
543	calsyntenin-3 precursor. [swissprot;acc:q9bqt9]		10599.9	12064.7
	cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851]	Subtracted	6228.39	7013.19	784.8
544	disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]
	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	Divided	3889.27	4426.74	1.13819
545	kininogen precursor (alpha-2-thiol proteinase inhibitor) [contains: bradykinin]. [swissprot;acc:p01042]	Subtracted	6228.39	7013.19	784.8
	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]	Divided	3889.27	4426.74	1.13819
546	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	Subtracted	6228.39	7013.19	784.8
	zinc finger protein t86. [swissprot;acc:o00488]	Divided	4052.77	4612.54	1.13812
547	ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	Subtracted	6228.39	7013.19	784.8
	werner helicase interacting protein isoform 1; putative helicase ruvbl; werner helicase interacting protein. [refseq;acc:nm_020135]	Divided	5291.92	6020.19	1.13762
548	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]		8268.19	9405.85	1.13759
	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	Subtracted	6228.39	7013.19	784.8
549	dolichol-phosphate mannosyltransferase (ec 2.4.1.83) (dolichol- phosphate mannose synthase) (dolichyl-phosphate beta-d- mannosyltransferase) (mannose-p-dolichol synthase) (mpd synthase) (dpm synthase). [swissprot;acc:o60762]	Divided	5865.79	6671.23	1.13731
	mitochondrial ferritin; ferritin heavy chain-like; ferritin h subunit. [refseq;acc:nm_177478]	Subtracted	6228.42	7013.21	784.79
550	ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]		6228.97	7013.53	784.56
	prohibitin. [swissprot;acc:p35232]	Divided	5773.45	6563.69	1.13687
551	adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]	Subtracted	6503.1	7282.94	779.84
	repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273]	Divided	5773.45	6563.69	1.13687
552	adenylosuccinate synthetase (ec 6.3.4.4) (imp--aspartate ligase) (adss) (ampsase). [swissprot;acc:p30520]	Subtracted	6503.03	7282.5	779.47
	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	Divided	15427.2	13572.8	1.13663
553	coatomer beta subunit (beta-coat protein) (beta-cop). [swissprot;acc:p53618]	Subtracted	10430.3	9656.4	773.9
	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]	Divided	3853.64	4379.71	1.13651
554	dendritic cell protein. [refseq;acc:nm_006360]	Subtracted	6593.17	7364.55	771.38

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.