MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1282 to 1331 of 14920 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	Value Type	description	Filtered	red	green	network_comparison
161	Measured	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	1	23693.7	18263	1.29736
	Ranked	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	0	5781.93	6660.63	1.15197
		rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	1	249.663	298.263	1.19466
	Squared	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]		173408	242989	1.40126
		udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:p36537]	0	6123.28	3763.18	1.62716
	Rooted	adp-ribosylation factor 3. [swissprot;acc:p16587]		14.8377	17.2252	1.16091
		ns1-associated protein 1. [refseq;acc:nm_006372]	1	52.7642	61.9019	1.17318
162	Measured	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	0	5734.28	7252.02	1.26468
		melanoma antigen, family b, 6. [refseq;acc:nm_173523]	1	23693.7	18263	1.29736
	Ranked	nostrin. [refseq;acc:nm_052946]		209.299	249.187	1.19058
		putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642]	0	12301.4	10680.5	1.15176
	Squared	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	1	173408	242989	1.40126
		udp-glucuronosyltransferase 2b15 precursor, microsomal (ec 2.4.1.17) (udpgt) (udpgth-3) (hlug4). [swissprot;acc:p54855]	0	6123.28	3763.18	1.62716
	Rooted	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	1	52.7642	61.9019	1.17318
		lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428]	0	9.27362	8	1.1592
163	Measured	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	1	23693.7	18263	1.29736
		myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	0	7830.62	6193.07	1.26442
	Ranked	eap30 subunit of ell complex. [refseq;acc:nm_007241]	1	209.299	249.187	1.19058
		transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]	0	8409.21	9668.79	1.14979
	Squared	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	1	173408	242989	1.40126
		p28 ing5. [refseq;acc:nm_032329]	0	5071.93	3165.6	1.6022
	Rooted	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	1	52.7702	61.8915	1.17285
		zinc finger protein 232. [swissprot;acc:q9uny5]	0	17.1325	14.7869	1.15863
164	Measured	aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]		1711.55	1354.26	1.26383
		melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	1	23693.7	18263	1.29736
	Ranked	dihydrofolate reductase (ec 1.5.1.3). [swissprot;acc:p00374]	0	11971.7	10412.4	1.14975
		liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	1	209.299	249.187	1.19058
	Squared	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	0	145.887	91.0551	1.60218
		homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	1	173408	242989	1.40126
	Rooted	mad protein (max dimerizer). [swissprot;acc:q05195]		55.646	65.1534	1.17086
		zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	0	17.1341	14.7892	1.15855
165	Measured	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	1	23693.7	18263	1.29736
		mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2]	0	1002.2	793.818	1.26251
	Ranked	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	1	209.299	249.187	1.19058
		ribose-phosphate pyrophosphokinase iii (ec 2.7.6.1) (phosphoribosyl pyrophosphate synthetase iii) (prs-iii). [swissprot;acc:p21108]	0	13255.4	15183.2	1.14544
	Squared	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	1	173408	242989	1.40126
		myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	0	54383.4	34012.2	1.59894
	Rooted	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	1	55.6486	65.1478	1.1707
		zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	0	17.1346	14.7899	1.15853
166	Measured	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]		5629.62	7099.51	1.2611
		melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	1	23693.7	18263	1.29736
	Ranked	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]		209.299	249.187	1.19058
		my016 protein. [sptrembl;acc:q9h3k6]	0	5561.19	6366.91	1.14488
	Squared	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	1	173408	242989	1.40126
		hsp90 co-chaperone cdc37 (hsp90 chaperone protein kinase-targeting subunit) (p50cdc37). [swissprot;acc:q16543]	0	220.039	350.57	1.59322
	Rooted	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	1	55.6495	65.1458	1.17064
		zinc finger imprinted 2. [swissprot;acc:q9nzv7]	0	17.1395	14.7969	1.15832
167	Measured	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	1	23693.7	18263	1.29736
		transcription factor mafk (erythroid transcription factor nf-e2 p18 subunit). [swissprot;acc:o60675]	0	331.61	417.983	1.26047
	Ranked	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	1	209.299	249.187	1.19058

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.