MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	green	Value Type	Interaction Map	Filtered	Network Comparison Type	network_comparison	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 9634 in total

Value Type  : Ranked
Network Comparison Type  : Divided

Rank	description	green	Interaction Map	Filtered	network_comparison	red
1	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	15915	High confidence	0	3.70633	4294
	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	32	Low confidence	1	2	16
	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	14977		0	2.55362	5865
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	24	High confidence	1	2.4	10
2	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	330	Low confidence		1.47982	223
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	28	High confidence		1.86667	15
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	21883	Low confidence	0	2.45711	8906
	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	14977	High confidence		2.55362	5865
3	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	330	Low confidence	1	1.47982	223
	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	28	High confidence		1.86667	15
	neurogenic locus notch homolog protein 1 precursor (notch 1) (hn1) (translocation-associated notch protein tan-1). [swissprot;acc:p46531]	20617	Low confidence	0	2.14604	9607
	nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]	11083.9	High confidence		2.47638	4475.84
4	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	330	Low confidence	1	1.47982	223
	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	28	High confidence		1.86667	15
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	21883		0	2.45711	8906
	neurogenic locus notch homolog protein 2 precursor (notch 2) (hn2). [swissprot;acc:q04721]	20617	Low confidence		2.14604	9607
5	cytohesin 4. [swissprot;acc:q9uia0]	28	High confidence	1	1.86667	15
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	330	Low confidence		1.47982	223
	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	11965.7	High confidence	0	2.17144	5510.5
	ubiquitously transcribed y chromosome tetratricopeptide repeat protein (ubiquitously transcribed tpr protein on the y chromosome). [swissprot;acc:o14607]	19873	Low confidence		1.82499	10889.4
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	28	High confidence	1	1.86667	15
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	240	Low confidence		1.325	318
	trinucleotide repeat containing 15. [refseq;acc:nm_015575]	9583.37		0	1.71877	5575.71
	ubiquitin protein ligase. [refseq;acc:nm_130466]	15339.2	High confidence		2.03897	7523
7	cab2. [refseq;acc:nm_033419]	10950			1.99689	21866
	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	6812	Low confidence		1.69451	11543
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	322	High confidence	1	1.49767	215
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	240	Low confidence		1.325	318
8	hbs1-like. [refseq;acc:nm_006620]	322	High confidence		1.49767	215
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	13216	Low confidence	0	1.68629	22286
	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	21888	High confidence		1.89918	11525
	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	240	Low confidence	1	1.325	318
9	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	44			1.31818	58
	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	13216		0	1.68629	22286
	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	21888	High confidence		1.89918	11525
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	309		1	1.45755	212
10	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	14178.1		0	1.88805	7509.39
	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	13216	Low confidence		1.68629	22286
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	44		1	1.31818	58
	protein x 0004. [refseq;acc:nm_016301]	309	High confidence		1.45755	212
11	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	8257	Low confidence	0	1.66289	13730.5
	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	28.4944		1	1.30966	37.318
	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	6248	High confidence	0	1.86092	11627
	rad50-interacting protein 1. [refseq;acc:nm_021930]	232		1	1.45259	337
12	anchor attachment protein 1; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (gaa1p, yeast) homolog. [refseq;acc:nm_003801]	1933	Low confidence	0	1.65028	3190
	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	5208.84	High confidence		1.81023	9429.18
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	232		1	1.45259	337
	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	28.5242	Low confidence		1.30933	37.3475
13	heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107]	9264.5	High confidence	0	1.77804	5210.5
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	29.1831	Low confidence	1	1.30207	37.9984

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.