MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Interaction Map	description	Value Type	Filtered	Network Comparison Type	green	network_comparison	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 33156 in total

Filtered  : 1
Network Comparison Type  : Divided

Rank	Interaction Map	description	Value Type	green	network_comparison	red
1	High confidence	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Ranked	24	2.4	10
		rad50-interacting protein 1. [refseq;acc:nm_021930]	Measured	2394.5	5.31521	450.5
			Squared	1357.07	28.2513	48.0356
			Rooted	48.9336	2.30547	21.225
	Low confidence	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Ranked	32	2	16
		lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Measured	543.5	4.4149	2399.5
			Squared	69.9153	19.4914	1362.75
			Rooted	23.3131	2.10117	48.9847
2	High confidence	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Ranked	28	1.86667	15
		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Measured	2394.5	5.31521	450.5
			Squared	1357.07	28.2513	48.0356
			Rooted	48.9336	2.30547	21.225
	Low confidence	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Measured	543.5	4.4149	2399.5
			Squared	69.9153	19.4914	1362.75
			Rooted	23.3131	2.10117	48.9847
		lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Ranked	330	1.47982	223
3	High confidence	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]		28	1.86667	15
		homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Measured	698.5	3.71868	2597.5
			Squared	115.48	13.8285	1596.92
			Rooted	26.4292	1.92839	50.9657
	Low confidence	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Ranked	330	1.47982	223
		cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Measured	543.5	4.4149	2399.5
			Squared	69.9153	19.4914	1362.75
			Rooted	23.3131	2.10117	48.9847
4	High confidence	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Ranked	28	1.86667	15
		hbs1-like. [refseq;acc:nm_006620]	Measured	698.5	3.71868	2597.5
			Squared	115.48	13.8285	1596.92
			Rooted	26.4292	1.92839	50.9657
	Low confidence	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Ranked	330	1.47982	223
		lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Measured	543.5	4.4149	2399.5
			Squared	69.9153	19.4914	1362.75
			Rooted	23.3131	2.10117	48.9847
5	High confidence	cytohesin 4. [swissprot;acc:q9uia0]	Ranked	28	1.86667	15
		junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Measured	339.5	3.39764	1153.5
			Squared	27.2805	11.544	314.926
			Rooted	18.4255	1.84327	33.9632
	Low confidence	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Ranked	330	1.47982	223
		oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Measured	2113.5	2.86965	736.5
			Squared	1057.25	8.23493	128.386
			Rooted	45.9728	1.69401	27.1385
6	High confidence	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Ranked	28	1.86667	15
		junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Measured	339.5	3.39764	1153.5
			Squared	27.2805	11.544	314.926
			Rooted	18.4255	1.84327	33.9632
	Low confidence	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Measured	2113.5	2.86965	736.5
			Squared	1057.25	8.23493	128.386
			Rooted	45.9728	1.69401	27.1385
		oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Ranked	240	1.325	318
7	High confidence	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		322	1.49767	215
		sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Measured	339.5	3.39764	1153.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.