MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Filtered	red	Interaction Map	network_comparison	green

Results: HTML CSV LaTeX

Showing element 3682 to 3731 of 9634 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	red	Interaction Map	network_comparison	green
1169	activator of basal transcription 1; tata-binding protein-binding protein; basal transcriptional activator. [refseq;acc:nm_013375]	219.399	High confidence	1.02626	213.784
	xpmc2 prevents mitotic catastrophe 2 homolog; xenopus prevents mitotic catastrophe 2 homolog. [refseq;acc:nm_020385]	200.521	Low confidence	1.02324	195.967
1170	cytokine-like nuclear factor n-pac. [refseq;acc:nm_032569]	219.399	High confidence	1.02626	213.784
	vacuolar proton translocating atpase 116 kda subunit a isoform 1 (clathrin-coated vesicle/synaptic vesicle proton pump 116 kda subunit) (vacuolar proton pump subunit 1) (vacuolar adenosine triphosphatase subunit ac116). [swissprot;acc:q93050]	192.255	Low confidence	1.02324	187.889
1171	cofilin, non-muscle isoform (18 kda phosphoprotein) (p18). [swissprot;acc:p23528]	201.061		1.02323	196.497
	hect type e3 ubiquitin ligase. [refseq;acc:nm_015052]	219.399	High confidence	1.02626	213.784
1172	transducin-like enhancer protein 1 (esg1). [swissprot;acc:q04724]	219.375		1.02623	213.767
	zinc transporter 3 (znt-3). [swissprot;acc:q99726]	204.466	Low confidence	1.02323	199.824
1173	candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	229.243	High confidence	1.02619	235.246
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	201.084	Low confidence	1.02322	196.52
1174	coatomer epsilon subunit (epsilon-coat protein) (epsilon-cop). [swissprot;acc:o14579]	187.964	High confidence	1.02599	192.849
	diaphanous protein homolog 3 (diaphanous-related formin 3) (drf3) (fragment). [swissprot;acc:q9nsv4]	200.258	Low confidence	1.02322	195.713
1175	cofilin, muscle isoform (cofilin 2). [swissprot;acc:q9y281]	201.033		1.02321	196.473
	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]	218.186	High confidence	1.02593	212.672
1176	destrin (actin-depolymerizing factor) (adf). [swissprot;acc:p18282]	201.013	Low confidence	1.02319	196.457
	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	218.186	High confidence	1.02593	212.672
1177	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]
	sodium/calcium exchanger 1 precursor (na(+)/ca(2+)-exchange protein 1). [swissprot;acc:p32418]	203.938	Low confidence	1.02318	199.317
1178	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]	218.186	High confidence	1.02593	212.672
	sodium/calcium exchanger 2 precursor (na(+)/ca(2+)-exchange protein 2). [swissprot;acc:q9upr5]	203.938	Low confidence	1.02318	199.317
1179	cellular modulator of immune recognition. [refseq;acc:nm_145021]	218.186	High confidence	1.02593	212.672
	methionyl-trna formyltransferase, mitochondrial precursor (ec 2.1.2.9) (mtfmt). [swissprot;acc:q96dp5]	201.447	Low confidence	1.02318	196.884
1180	sodium/calcium exchanger 3 precursor (na(+)/ca(2+)-exchange protein 3) (fragment). [swissprot;acc:p57103]	203.938			199.317
	vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437]	218.186	High confidence	1.02593	212.672
1181	gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326]
	rhesus blood group-associated glycoprotein (erythrocyte plasma membrane 50 kda glycoprotein) (rh50a). [swissprot;acc:q02094]	201.302	Low confidence	1.02317	196.744
1182	neurocalcin delta. [swissprot;acc:p29554]	225.104	High confidence	1.02589	230.931
	potassium channel modulatory factor 1; potassium channel modulatory factor; differentially expressed in branching tubulogenesis 91; zinc finger, zz domain containing 1. [refseq;acc:nm_020122]	206.598	Low confidence	1.02315	201.924
1183	neuron specific calcium-binding protein hippocalcin (p23k) (calcium- binding protein bdr-2). [swissprot;acc:p32076]	225.103	High confidence	1.02588	230.928
	tyrosine-protein kinase ryk precursor (ec 2.7.1.112). [swissprot;acc:p34925]	203.427	Low confidence	1.02315	198.825
1184	arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]	216.729	High confidence	1.02586	222.334
	iroquois-class homeodomain protein irx-3 (iroquois homeobox protein 3) (fragment). [swissprot;acc:p78415]	195.226	Low confidence	1.02313	190.812
1185	iroquois-class homeodomain protein irx-5 (iroquois homeobox protein 5) (irx-2a). [swissprot;acc:p78411]
	visinin-like protein 3 (vilip-3) (calcium-binding protein bdr-1) (hlp2) (hippocalcin-like protein 1). [swissprot;acc:p37235]	225.094	High confidence	1.02585	230.913
1186	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]	218.402		1.02582	212.904
	iroquois-class homeodomain protein irx-2 (iroquois homeobox protein 2) (fragment). [swissprot;acc:q9bzi1]	195.226	Low confidence	1.02313	190.812
1187	iroquois-class homeodomain protein irx-1 (iroquois homeobox protein 1) (fragment). [swissprot;acc:p78414]
	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase ac39 subunit) (v-atpase 40 kda accessory protein) (p39) (32 kda accessory protein). [swissprot;acc:p12953]	218.402	High confidence	1.02582	212.904
1188	adp-ribosylation factor-like protein 4. [swissprot;acc:p40617]
	transducin beta-like 3; wd-repeat protein sazd. [refseq;acc:nm_006453]	202.963	Low confidence	1.02311	198.378
1189	alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]	209.649	High confidence	1.02565	204.406
	iroquois-class homeodomain protein irx-4 (iroquois homeobox protein 4). [swissprot;acc:p78413]	195.344	Low confidence	1.02311	190.932
1190	bleomycin hydrolase (ec 3.4.22.40) (blm hydrolase) (bmh) (bh). [swissprot;acc:q13867]	202.963			198.378
	ubiquitin. [swissprot;acc:p02248]	209.6	High confidence	1.02558	204.372
1191	upstream binding protein 1 (lbp-1a). [refseq;acc:nm_014517]	220.742			215.237
	zinc finger protein gli3. [swissprot;acc:p10071]	203.052	Low confidence	1.02311	198.466
1192	adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]	199.02		1.02309	194.529
	transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]	220.742	High confidence	1.02558	215.237
1193	lbp-9. [refseq;acc:nm_014553]
	tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]	201.092	Low confidence	1.02309	196.553

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.