MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Filtered	green	network_comparison	Value Type	Interaction Map	description	Network Comparison Type	Rank	red	Gene

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Showing element 3180 to 3229 of 77072 in total

Filtered  : 0

green	network_comparison	Value Type	Interaction Map	description	Network Comparison Type	Rank	red
50	1.66667	Measured	Low confidence	transcription initiation factor iie, beta subunit (tfiie-beta). [swissprot;acc:p29084]	Divided	80	30
	20		High confidence		Subtracted	426
			Low confidence			743
50.3308	1.02076	Squared		similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	Divided	739	51.3755
	1.0447				Subtracted	802
50.3885	1.05014	Rooted		hepatocellularcarcinoma-associated antigen hca557a. [refseq;acc:nm_015433]	Divided	526	52.915
	2.5265				Subtracted	320
50.4997	1.03076		High confidence	ubiquinol-cytochrome c reductase complex core protein i, mitochondrial precursor (ec 1.10.2.2). [swissprot;acc:p31930]	Divided	424	48.9929
	1.5068				Subtracted	317
50.7408	3.12432	Squared		protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981]	Divided	69	16.2406
	34.5002				Subtracted	355
50.7888	1.06535	Rooted	Low confidence	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	Divided	460	47.6732
	3.1156				Subtracted	268
51	1.0625	Measured	High confidence	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Divided	354	48
				melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]		350
				melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]		363
				melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]		364
				melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]		352
				melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]		362
				melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]		353
				melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]		351
				melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]		358
				melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]		355
				melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]		360
				melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]		359
				melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]		365
				melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]		361
				melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]		356
				melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]		366
				melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]		357
	3			hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Subtracted	471
				melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]		467
				melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]		481
				melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]		482
				melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]		469
				melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]		480
				melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]		470
				melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]		468
				melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]		475
				melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]		472
				melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]		477
				melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]		476
				melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]		483
				melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]		478
				melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]		473
				melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]		484
				melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]		474
51.3517	1.19943	Rooted		spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813]	Divided	135	42.8135
	8.5382				Subtracted	41
51.7359	1.03118		Low confidence	ganglioside induced differentiation associated protein 2; likely ortholog of mouse ganglioside-induced differentiation-associated-protein 2. [refseq;acc:nm_017686]	Divided	622	50.1714

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.