MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 325 to 374 of 3730 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	Filtered	red	green	network_comparison
163	eap30 subunit of ell complex. [refseq;acc:nm_007241]	1	209.299	249.187	1.19058
	transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]	0	8409.21	9668.79	1.14979
164	dihydrofolate reductase (ec 1.5.1.3). [swissprot;acc:p00374]		11971.7	10412.4	1.14975
	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	1	209.299	249.187	1.19058
165	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]
	ribose-phosphate pyrophosphokinase iii (ec 2.7.6.1) (phosphoribosyl pyrophosphate synthetase iii) (prs-iii). [swissprot;acc:p21108]	0	13255.4	15183.2	1.14544
166	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	1	209.299	249.187	1.19058
	my016 protein. [sptrembl;acc:q9h3k6]	0	5561.19	6366.91	1.14488
167	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	1	209.299	249.187	1.19058
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	0	12157.6	13890.3	1.14252
168	fos-related antigen 2. [swissprot;acc:p15408]		7091.75	6217.28	1.14065
	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	1	82.5916	98.0548	1.18722
169	alanine aminotransferase (ec 2.6.1.2) (glutamic--pyruvic transaminase) (gpt) (glutamic--alanine transaminase). [swissprot;acc:p24298]	0	9875.43	11256.8	1.13988
	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	1	82.5916	98.0548	1.18722
170	low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]	0	11364	12941	1.13877
	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	1	227.199	192.715	1.17894
171	lamin b2. [swissprot;acc:q03252]	0	12135.4	13802	1.13733
	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	1	227.202	192.823	1.17829
172	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]		174.667	205.556	1.17685
	zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]	0	12225.7	13893.1	1.13638
173	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	1	227.032	193.056	1.17599
	suppressor of actin 1. [refseq;acc:nm_014016]	0	19088.1	16804.6	1.13589
174	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	1	335	286	1.17133
	ribulose-5-phosphate-3-epimerase; ribulose 5-phosphate 3-epimerase. [refseq;acc:nm_006916]	0	13248.5	11666.4	1.13561
175	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	1	199.949	234.187	1.17123
	thiamin pyrophosphokinase 1; mouse thiamin pyrophosphokinase homolog; thiamine pyrophosphokinase. [refseq;acc:nm_022445]	0	13248.5	11666.4	1.13561
176	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]		13068	11528	1.13359
	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	1	275.754	235.908	1.1689
177	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]		229.406	196.695	1.1663
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	0	14922.7	13174.5	1.1327
178	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	1	226.887	194.72	1.1652
	integral membrane protein cii-3b. [sptrembl;acc:o75609]	0	14951.6	13204.2	1.13234
179	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	1	226.884	194.79	1.16476
	mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426]	0	9473.01	10723.7	1.13203
180	rna-binding protein nova-1 (neuro-oncological ventral antigen 1) (onconeural ventral antigen-1) (paraneoplastic ri antigen) (ventral neuron-specific protein 1). [swissprot;acc:p51513]		8407.67	9516.92	1.13193
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	1	256.228	298.438	1.16474
181	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		229.818	267.265	1.16294
	importin 7; ran-binding protein 7. [refseq;acc:nm_006391]	0	14864.7	16820.7	1.13159
182	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	1	277.546	240.461	1.15422
	putative inorganic polyphosphate/atp-nad kinase (ec 2.7.1.23) (poly(p)/atp nad kinase). [swissprot;acc:o95544]	0	11573.8	10231.3	1.13121
183	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	1	228.306	198.011	1.153
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	0	11613	13133.5	1.13093
184	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	1	274.027	237.79	1.15239
	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	0	6279.56	5569.42	1.12751
185	adiponectin receptor 2. [refseq;acc:nm_024551]	1	281.582	246.371	1.14292
	zinc finger protein 277. [swissprot;acc:q9nrm2]	0	6279.56	5569.42	1.12751
186	40s ribosomal protein s2 (s4) (llrep3 protein). [swissprot;acc:p15880]		11935.1	10592.8	1.12672
	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	1	226.582	198.444	1.14179
187	adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]	0	9955.22	11213.7	1.12641
	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	1	226.582	198.444	1.14179

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.