MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Interaction Map	network_comparison	Value Type	Filtered	Network Comparison Type	green	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 14920 in total

Interaction Map  : High confidence
Network Comparison Type  : Divided

Rank	description	network_comparison	Value Type	Filtered	green	red
1	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	3.70633	Ranked	0	15915	4294
	cab2. [refseq;acc:nm_033419]	716592	Squared		7.16592	0.00001
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	1907880	Rooted		0.00001	19.0788
		36400000	Measured			364
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	2.4	Ranked	1	24	10
	rad50-interacting protein 1. [refseq;acc:nm_021930]	2.30547	Rooted		48.9336	21.225
		5.31521	Measured		2394.5	450.5
		28.2513	Squared		1357.07	48.0356
2	cab2. [refseq;acc:nm_033419]	17400000	Measured	0	174	0.00001
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	1.86667	Ranked	1	28	15
	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	2.55362		0	14977	5865
	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	561325	Squared		0.00001	5.61325
		1240970	Rooted			12.4097
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	2.30547		1	48.9336	21.225
		5.31521	Measured		2394.5	450.5
		28.2513	Squared		1357.07	48.0356
3	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	1.86667	Ranked		28	15
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	1.92839	Rooted		26.4292	50.9657
		3.71868	Measured		698.5	2597.5
		13.8285	Squared		115.48	1596.92
	nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]	2.47638	Ranked	0	11083.9	4475.84
	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	10900000	Measured		109	0.00001
	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	561325	Squared		0.00001	5.61325
		1240970	Rooted			12.4097
4	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	1.86667	Ranked	1	28	15
	hbs1-like. [refseq;acc:nm_006620]	1.92839	Rooted		26.4292	50.9657
		3.71868	Measured		698.5	2597.5
		13.8285	Squared		115.48	1596.92
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	8900000	Measured	0	89	0.00001
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	2.45711	Ranked		21883	8906
	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	281207	Squared		2.81207	0.00001
		1044030	Rooted		10.4403
5	cytohesin 4. [swissprot;acc:q9uia0]	1.86667	Ranked	1	28	15
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	187479	Squared	0	1.87479	0.00001
		943398	Rooted		9.43398
	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	8900000	Measured		89
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	1.84327	Rooted	1	18.4255	33.9632
		3.39764	Measured		339.5	1153.5
		11.544	Squared		27.2805	314.926
	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	2.17144	Ranked	0	11965.7	5510.5
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	1.86667		1	28	15
	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	8900000	Measured	0	89	0.00001
	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	187479	Squared		1.87479
		943398	Rooted		9.43398
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	1.84327		1	18.4255	33.9632
		3.39764	Measured		339.5	1153.5
		11.544	Squared		27.2805	314.926
	ubiquitin protein ligase. [refseq;acc:nm_130466]	2.03897	Ranked	0	15339.2	7523
7	cab2. [refseq;acc:nm_033419]	1.99689			10950	21866
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	1.49767		1	322	215

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.