MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Network Comparison Type	Value Type	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	network_comparison	red	green
1	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Subtracted	8126	41482.5	33356.5
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Divided	5.31521	450.5	2394.5
2	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Subtracted	8126	41482.5	33356.5
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided	5.31521	450.5	2394.5
3	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Subtracted	8126	41482.5	33356.5
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	3.71868	2597.5	698.5
4	cytohesin 4. [swissprot;acc:q9uia0]	Subtracted	8126	41482.5	33356.5
	hbs1-like. [refseq;acc:nm_006620]	Divided	3.71868	2597.5	698.5
5	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Subtracted	8126	41482.5	33356.5
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Divided	3.39764	1153.5	339.5
6	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Subtracted	7563	44490.5	36927.5
7	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		7307	21185	28492
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Divided	3.39764	1153.5	339.5
8	db83 protein. [swissprot;acc:p57088]
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Subtracted	7307	21185	28492
9	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Divided	3.21581	398.5	1281.5
10	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	Subtracted	7307	21185	28492
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Divided	3.21581	398.5	1281.5
11	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Subtracted	7307	21185	28492
12	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Divided	3.21581	398.5	1281.5
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Subtracted	6604.9	34190.9	40795.8
13	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Divided	3.21581	398.5	1281.5
	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Subtracted	6313	21591.5	27904.5
14	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]
	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	Divided	3.21581	398.5	1281.5
15	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Subtracted	6313	21591.5	27904.5
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Divided	3.06659	2671	871
16	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	Subtracted	6088.2	24260.3	18172.1
	protein x 0004. [refseq;acc:nm_016301]	Divided	3.06659	2671	871
17	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]		2.96739	460	1365
	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	Subtracted	6086.8	24255.7	18168.9
18	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]
	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Divided	2.75351	677.5	1865.5
19	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Subtracted	6085.1	24250	18164.9
	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Divided	2.75351	677.5	1865.5
20	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Subtracted	5841.1	23421.5	17580.4
	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	Divided	2.75351	677.5	1865.5
21	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]
	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Subtracted	5430.7	23693.7	18263
22	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]
	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	Divided	2.75351	677.5	1865.5
23	gbp protein isoform a. [refseq;acc:nm_017870]		2.7072	699.76	1894.39
	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Subtracted	5430.7	23693.7	18263
24	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Divided	2.21818	950.561	2108.52
25	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]		2.0534	1833.01	892.67
	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Subtracted	5430.7	23693.7	18263

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.