MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 575 to 624 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	red	green	network_comparison
288	40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]	High confidence	240.758	266.078	1.10517
	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	Low confidence	200.288	192.004	1.04314
289	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	High confidence	272.781	246.892	1.10486
	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	Low confidence	209.31	200.66	1.04311
290	lysosomal-associated transmembrane protein 4 beta; putative integral membrane transporter. [refseq;acc:nm_018407]		210	201.325	1.04309
	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]	High confidence	231.969	210.064	1.10428
291	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208]		251.679	228.037	1.10368
	pl6 protein (placental protein 6). [swissprot;acc:q12893]	Low confidence	209.995	201.322	1.04308
292	40s ribosomal protein s15a. [swissprot;acc:p39027]	High confidence	241.411	266.414	1.10357
	lysosomal-associated transmembrane protein 4a (golgi 4-transmembrane spanning transporter mtp). [swissprot;acc:q15012]	Low confidence	209.995	201.322	1.04308
293	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	High confidence	240.782	265.717	1.10356
	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]	Low confidence	218.785	209.763	1.04301
294	brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567]	High confidence	240.782	265.717	1.10356
	jagged 2 precursor (jagged2) (hj2). [swissprot;acc:q9y219]	Low confidence	218.715	209.71	1.04294
295	multisynthetase complex auxiliary component p43 [contains: endothelial-monocyte activating polypeptide ii (emap-ii) (small inducible cytokine subfamily e member 1)]. [swissprot;acc:q12904]	High confidence	223.273	202.423	1.103
	myocyte-specific enhancer factor 2d. [swissprot;acc:q14814]	Low confidence	218.713	209.709	1.04294
296	jagged 1 precursor (jagged1) (hj1). [swissprot;acc:p78504]		218.714
	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	High confidence	241.282	266.12	1.10294
297	60s ribosomal protein l7. [swissprot;acc:p18124]		235.727	259.984	1.1029
	myocyte-specific enhancer factor 2c. [swissprot;acc:q06413]	Low confidence	218.714	209.709	1.04294
298	calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]	High confidence	268.632	243.588	1.10281
	myocyte-specific enhancer factor 2a (serum response factor-like protein 1). [swissprot;acc:q02078]	Low confidence	218.715	209.71	1.04294
299	calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	High confidence	268.635	243.592	1.10281
	endoribonuclease dicer (ec 3.1.26.-) (helicase with rnase motif) (helicase-moi). [swissprot;acc:q9upy3]	Low confidence	208.915	200.322	1.0429
300	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]		218.661	209.669	1.04289
	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]	High confidence	150.959	166.351	1.10196
301	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]		150.982	166.372	1.10193
	large neutral amino acids transporter small subunit 2 (l-type amino acid transporter 2) (hlat2). [swissprot;acc:q9uhi5]	Low confidence	205.154	196.72	1.04287
302	60s ribosomal protein l26. [swissprot;acc:q02877]	High confidence	242.326	267.008	1.10185
	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	Low confidence	209.12	200.548	1.04274
303	60s ribosomal protein l35. [swissprot;acc:p42766]	High confidence	242.333	266.999	1.10179
	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	Low confidence	210.057	201.45	1.04273
304	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	High confidence	242.339	266.986	1.1017
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	Low confidence	209.232	200.662	1.04271
305	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]		210.05	201.454	1.04267
	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	High confidence	242.339	266.986	1.1017
306	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]		242.153	266.673	1.10126
	small nuclear ribonucleoprotein f (snrnp-f) (sm protein f) (sm-f) (smf). [swissprot;acc:q15356]	Low confidence	202.122	193.867	1.04258
307	phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (ec 2.7.1.38) (phosphorylase kinase gamma subunit 1). [swissprot;acc:q16816]		217.957	227.209	1.04245
	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	High confidence	242.153	266.673	1.10126
308	60s ribosomal protein l34. [swissprot;acc:p49207]
	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	Low confidence	210.018	201.475	1.0424
309	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]		200.213	192.103	1.04222
	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	High confidence	242.153	266.673	1.10126
310	nadh-ubiquinone oxidoreductase 39 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-39kd) (ci-39kd). [swissprot;acc:q16795]	Low confidence	205.75	197.484	1.04186
	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	High confidence	242.153	266.673	1.10126
311	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]		242.627	267.151	1.10108
	ubiquitin-activating enzyme e1c (uba3 homolog, yeast); ubiquitin-activating enzyme e1c (homologous to yeast uba3). [refseq;acc:nm_003968]	Low confidence	192.088	184.374	1.04184
312	60s ribosomal protein l3-like. [swissprot;acc:q92901]	High confidence	242.195	266.663	1.10103
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	Low confidence	202.051	193.937	1.04184

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.