MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Interaction Map	Network Comparison Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2051 to 2100 of 12912 in total

Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
513	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	Ranked	218.596	204.344	1.06975
	transforming protein rhoc (h9). [swissprot;acc:p08134]	Squared	19987.6	23960.7	1.19878
514	1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	Measured	7477	8532.02	1.1411
	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	Ranked	218.613	204.382	1.06963
	thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [swissprot;acc:q16762]	Squared	19987.6	23960.7	1.19878
	xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7]	Rooted	58.7805	64.0772	1.09011
515	3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	Squared	19987.6	23960.7	1.19878
	pescadillo homolog 1. [swissprot;acc:o00541]	Ranked	251.297	234.941	1.06962
	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	Measured	3890.53	4439.07	1.14099
	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	Rooted	56.3551	61.4322	1.09009
516	adenylate kinase isoenzyme 2, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p54819]		50.7935	46.6042	1.08989
	n-acetylgalactosamine kinase (ec 2.7.1.-) (galnac kinase) (galactokinase 2). [swissprot;acc:q01415]	Measured	4910.6	5600.61	1.14051
	transforming protein rhoa (h12). [swissprot;acc:p06749]	Squared	19987.6	23960.7	1.19878
	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	Ranked	228.255	213.422	1.0695
517	eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]	Rooted	50.0578	54.5502	1.08974
	galactose-1-phosphate uridylyltransferase (ec 2.7.7.12) (gal-1-p uridylyltransferase) (udp-glucose--hexose-1-phosphate uridylyltransferase). [swissprot;acc:p07902]	Measured	4910.6	5600.61	1.14051
	metaxin 2. [swissprot;acc:o75431]	Ranked	219.537	234.793	1.06949
	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	Squared	19263.3	23092.3	1.19877
518	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	Ranked	250.858	234.563	1.06947
	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	Squared	11447.3	13719.2	1.19847
	trinucleotide repeat containing 15. [refseq;acc:nm_015575]	Rooted	50.0578	54.5502	1.08974
	udp-glucose 4-epimerase (ec 5.1.3.2) (galactowaldenase) (udp- galactose 4-epimerase). [swissprot;acc:q14376]	Measured	4910.6	5600.61	1.14051
519	glycogen [starch] synthase, muscle (ec 2.4.1.11). [swissprot;acc:p13807]		9648.27	10994.9	1.13957
	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	Squared	22387.1	26827.3	1.19834
	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	Ranked	218.702	204.582	1.06902
	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Rooted	114.309	124.527	1.08939
520	breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]		61.1902	66.6503	1.08923
	endo-beta-n-acetylglucosaminidase. [refseq;acc:nm_022759]	Measured	9642.22	10986.4	1.13941
	paxillin. [swissprot;acc:p49023]	Squared	22387.1	26827.3	1.19834
	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	Ranked	214.754	229.565	1.06897
521	carboxypeptidase a5. [refseq;acc:nm_080385]	Squared	53174	44377.4	1.19822
	cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]	Rooted	61.1902	66.6503	1.08923
	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]	Ranked	215.237	230.07	1.06891
	u4/u6-associated rna splicing factor. [refseq;acc:nm_004698]	Measured	5390.78	6142.07	1.13937
522	carboxypeptidase b precursor (ec 3.4.17.2) (pancreas-specific protein) (pasp). [swissprot;acc:p15086]	Squared	53174	44377.4	1.19822
	glycogen [starch] synthase, liver (ec 2.4.1.11). [swissprot;acc:p54840]	Measured	9634.98	10976.2	1.1392
	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	Ranked	222.893	208.523	1.06891
	septin 10 isoform 1. [refseq;acc:nm_144710]	Rooted	113.733	123.871	1.08914
523	aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]	Measured	10640.2	12117.8	1.13887
	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	Ranked	215.237	230.07	1.06891
	neutral and basic amino acid transport protein rbat (b(0,+)-type amino acid transport protein) (nbat) (d2h). [swissprot;acc:q07837]	Squared	53174	44377.4	1.19822
	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	Rooted	66.377	72.2842	1.08899
524	aminoacylase-1 (ec 3.5.1.14) (n-acyl-l-amino-acid amidohydrolase) (acy-1). [swissprot;acc:q03154]	Squared	53174	44377.4	1.19822
	aquaporin 5. [swissprot;acc:p55064]	Measured	10640	12117.6	1.13887
	brain protein 44. [swissprot;acc:o95563]	Rooted	113.374	123.463	1.08899
	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	Ranked	215.237	230.07	1.06891
525	carboxypeptidase a1 precursor (ec 3.4.17.1). [swissprot;acc:p15085]	Squared	53174	44377.4	1.19822
	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	Ranked	215.237	230.07	1.06891
	lens fiber major intrinsic protein (mip26) (mp26) (aquaporin 0). [swissprot;acc:p30301]	Measured	10639.8	12117.3	1.13887
	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Rooted	113.374	123.463	1.08899

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.