MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 701 to 750 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
176	bet3 homolog. [swissprot;acc:o43617]	Squared	112820	157033	1.39189
	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	Ranked	275.754	235.908	1.1689
	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	Measured	4456.93	5773.67	1.29544
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	Rooted	145.551	168.796	1.1597
177	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	Ranked	229.406	196.695	1.1663
	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	Measured	4457.06	5773.63	1.29539
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Rooted	145.551	168.796	1.1597
	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	Squared	78383	108483	1.38401
178	carboxypeptidase b precursor. [refseq;acc:nm_020361]		25326.4	18354.1	1.37988
	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Ranked	226.887	194.72	1.1652
	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Measured	21591.5	27904.5	1.29238
	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	Rooted	45.7414	52.932	1.1572
179	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Ranked	226.884	194.79	1.16476
	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	Squared	25326.3	18354.1	1.37987
	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	Measured	21591.5	27904.5	1.29238
	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	Rooted	50.272	43.4634	1.15665
180	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]		50.2801	43.4779	1.15645
	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Measured	21591.5	27904.5	1.29238
	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	Squared	25326.2	18354.1	1.37987
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	Ranked	256.228	298.438	1.16474
181	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		229.818	267.265	1.16294
	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	Rooted	57.4432	66.3307	1.15472
	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	Measured	4068.56	5252.6	1.29102
	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	Squared	55630.4	76083.7	1.36766
182	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (ec 3.6.1.23) (dutpase) (dutp pyrophosphatase). [swissprot;acc:p33316]		61733.5	45224.1	1.36506
	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Ranked	277.546	240.461	1.15422
	rna-binding protein. [refseq;acc:nm_019027]	Measured	4069.83	5252.17	1.29051
	t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991]	Rooted	57.45	66.332	1.1546
183	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	Ranked	228.306	198.011	1.153
	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]	Squared	79779.8	108084	1.35478
	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	Measured	4069.83	5252.17	1.29051
	enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511]	Rooted	57.4586	66.3336	1.15446
184	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]		153.602	133.195	1.15321
	ns1-associated protein 1. [refseq;acc:nm_006372]	Measured	4069.83	5252.17	1.29051
	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	Ranked	274.027	237.79	1.15239
	small glutamine rich protein with tetratricopeptide repeats 2. [refseq;acc:nm_019072]	Squared	72886.3	98544.5	1.35203
185	adiponectin receptor 2. [refseq;acc:nm_024551]	Ranked	281.582	246.371	1.14292
	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	Squared	41502.9	30836.8	1.34589
	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	Measured	4069.83	5252.17	1.29051
	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	Rooted	153.578	133.176	1.1532
186	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Measured	4071.1	5251.75	1.29001
	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	Ranked	226.582	198.444	1.14179
	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	Squared	41502.9	30836.8	1.34589
	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	Rooted	153.578	133.176	1.1532
187	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]		153.548	133.153	1.15317
	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]	Squared	41502.9	30836.8	1.34589
	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	Ranked	226.582	198.444	1.14179
	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	Measured	4569.48	5885.79	1.28807
188	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	Squared	41502.9	30836.8	1.34589
	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	Ranked	226.582	198.444	1.14179

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.