MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3658 to 3707 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
915	highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	Rooted	55.2209	52.1262	1.05937
	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	Squared	19364.5	22408.8	1.15721
	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]	Ranked	146.036	140.692	1.03798
916	annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	Rooted	61.4775	65.1209	1.05926
	cytochrome b5 reductase 1 (b5r.1). [refseq;acc:nm_016243]	Measured	6289.72	6911.96	1.09893
	fibulin-1 precursor. [swissprot;acc:p23142]	Squared	44407.1	51387.4	1.15719
	hydroxyacid oxidase 2 (ec 1.1.3.15) (haox2) ((s)-2-hydroxy-acid oxidase, peroxisomal) (long chain alpha-hydroxy acid oxidase) (long- chain l-2-hydroxy acid oxidase). [swissprot;acc:q9nyq3]	Ranked	232.512	241.288	1.03774
917	histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	Squared	23294.5	26946.3	1.15677
	nadh-cytochrome b5 reductase (ec 1.6.2.2) (b5r). [swissprot;acc:p00387]	Measured	6289.72	6911.96	1.09893
	parafibromin. [refseq;acc:nm_024529]	Ranked	239.704	230.991	1.03772
	steroid hormone receptor err2 (estrogen-related receptor, beta) (err-beta) (estrogen receptor-like 2) (err beta-2). [swissprot;acc:o95718]	Rooted	82.3879	87.2663	1.05921
918	atpase, h+ transporting, lysosomal 38kda, v0 subunit d isoform 2. [refseq;acc:nm_152565]		62.3496	66.0388	1.05917
	metastasis-associated protein mta1. [swissprot;acc:q13330]	Squared	23321.7	26976.4	1.15671
	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	Ranked	212.952	205.292	1.03731
	scratch; scratch 1. [refseq;acc:nm_031309]	Measured	7281.6	8001.64	1.09888
919	chromatin assembly factor 1 subunit c (caf-1 subunit c) (chromatin assembly factor i p48 subunit) (caf-i 48 kda subunit) (caf-ip48) (retinoblastoma binding protein p48) (retinoblastoma-binding protein 4) (rbbp-4) (msi1 protein homolog). [swissprot;acc:q09028]	Squared	23346.9	27004.3	1.15665
	limbic system-associated membrane protein precursor (lsamp). [swissprot;acc:q13449]	Measured	5396.36	5929.41	1.09878
	midasin (midas-containing protein). [swissprot;acc:q9nu22]	Ranked	237.218	228.698	1.03725
	p66 alpha. [refseq;acc:nm_017660]	Rooted	93.8375	88.6044	1.05906
920	deformed epidermal autoregulatory factor 1 homolog (nuclear deaf-1 related transcriptional regulator) (nudr) (suppressin) (zinc finger mynd domain containing protein 5). [swissprot;acc:o75398]	Ranked	236.741	245.547	1.0372
	dj850e9.1 (novel c2h2 type zinc finger protein similar to drosophila scratch (scrt), slug and xenopus snail) (fragment). [sptrembl;acc:q9nq03]	Measured	7273.78	7991.72	1.0987
	protein cgi-147. [swissprot;acc:q9y3e5]	Squared	36787.9	31806.3	1.15662
	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	Rooted	93.8375	88.6044	1.05906
921	14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	Squared	25739.7	29768.2	1.15651
	rio kinase 1 isoform 1; ad034 protein. [refseq;acc:nm_031480]	Ranked	236.741	245.547	1.0372
	translation initiation factor if-2, mitochondrial precursor (if-2mt) (if-2(mt)). [swissprot;acc:p46199]	Measured	6324.31	6948.5	1.0987
	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	Rooted	93.8375	88.6044	1.05906
922	6-phosphogluconate dehydrogenase, decarboxylating (ec 1.1.1.44). [swissprot;acc:p52209]	Squared	27031.3	31257.4	1.15634
	map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650]	Ranked	236.741	245.547	1.0372
	tubulin-tyrosine ligase. [refseq;acc:nm_153712]	Measured	5511.2	6054.71	1.09862
	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]	Rooted	62.0422	65.7019	1.05899
923	elongation factor 2 (ef-2). [swissprot;acc:p13639]	Squared	23598.8	27286.9	1.15628
	eukaryotic translation initiation factor 3 subunit 8 (eif3 p110) (eif3c). [swissprot;acc:q99613]	Measured	4057.54	4457.66	1.09861
	map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954]	Ranked	236.741	245.547	1.0372
	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	Rooted	62.0422	65.7019	1.05899
924	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]
	meiotic recombination protein spo11. [swissprot;acc:q9y5k1]	Ranked	236.741	245.547	1.0372
	metabotropic glutamate receptor 2 precursor (mglur2). [swissprot;acc:q14416]	Squared	23598.8	27286.9	1.15628
	opioid binding protein/cell adhesion molecule precursor (obcam) (opioid-binding cell adhesion molecule) (opcml). [swissprot;acc:q14982]	Measured	5406.5	5939.42	1.09857
925	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]	Rooted	62.0422	65.7019	1.05899
	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]	Squared	23598.8	27286.9	1.15628
	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	Ranked	215.665	207.942	1.03714
	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 1). [swissprot;acc:q15118]	Measured	5637.43	6193.07	1.09856
926	cellular modulator of immune recognition. [refseq;acc:nm_145021]	Rooted	62.0422	65.7019	1.05899
	eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884]	Squared	17373.9	20087.4	1.15618
	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	Ranked	217.942	210.139	1.03713
	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 2). [swissprot;acc:q15119]	Measured	5637.45	6193.08	1.09856
927	dipeptidylpeptidase 10; dipeptidyl peptidase iv-related protein 3. [refseq;acc:nm_020868]		5638.64	6194.22	1.09853
	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	Ranked	217.942	210.139	1.03713
	transaldolase (ec 2.2.1.2). [swissprot;acc:p37837]	Squared	24049.1	27802.5	1.15607

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.