MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1732 to 1781 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
433	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	Ranked	212.547	229.411	1.07934
434	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	Squared	18306.1	22230.6	1.21438
	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	Ranked	212.547	229.411	1.07934
	thymic stromal co-transporter. [refseq;acc:nm_033051]	Rooted	54.4927	49.6125	1.09837
	ubiquinol-cytochrome c reductase complex core protein i, mitochondrial precursor (ec 1.10.2.2). [swissprot;acc:p31930]	Measured	5246.38	6037.37	1.15077
435	60s ribosomal protein l19. [swissprot;acc:p14118]	Rooted	50.832	46.3081	1.09769
	cytochrome b5 reductase b5r.2. [refseq;acc:nm_016229]	Squared	26598.9	32283.5	1.21372
	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	Ranked	221.522	205.286	1.07909
	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	Measured	5233.86	6022.6	1.1507
436	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]		6230.94	7168.2	1.15042
	cytochrome b5 reductase 1 (b5r.1). [refseq;acc:nm_016243]	Squared	26598.9	32283.5	1.21372
	paxillin. [swissprot;acc:p49023]	Ranked	221.522	205.286	1.07909
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Rooted	210.928	192.165	1.09764
437	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	Ranked	209.921	226.459	1.07878
	nadh-cytochrome b5 reductase (ec 1.6.2.2) (b5r). [swissprot;acc:p00387]	Squared	26598.9	32283.5	1.21372
	suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55]	Measured	3779.92	4348.48	1.15042
	zinc finger protein t86. [swissprot;acc:o00488]	Rooted	51.0466	56.024	1.09751
438	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	Squared	28863.2	35031.5	1.21371
	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	Rooted	55.1867	60.5522	1.09722
	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	Ranked	233.723	216.674	1.07869
	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	Measured	6252.58	7192.88	1.15039
439	40s ribosomal protein s9. [swissprot;acc:p46781]	Ranked	238.986	257.784	1.07866
	cell division cycle protein 23; anaphase-promoting complex subunit 8. [refseq;acc:nm_004661]	Squared	51616.7	42588.9	1.21198
	dok-like protein. [refseq;acc:nm_024872]	Rooted	63.2134	69.352	1.09711
	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]	Measured	6252.58	7192.88	1.15039
440	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]		6251.91	7192.08	1.15038
	dna topoisomerase ii, alpha isozyme (ec 5.99.1.3). [swissprot;acc:p11388]	Squared	26348.4	31925.8	1.21168
	docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]	Rooted	63.2134	69.352	1.09711
	highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	Ranked	231.802	249.983	1.07843
441	dna topoisomerase ii, beta isozyme (ec 5.99.1.3). [swissprot;acc:q02880]	Squared	26348.7	31924.3	1.21161
	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]	Rooted	63.2134	69.352	1.09711
	grancalcin. [swissprot;acc:p28676]	Measured	6251.96	7192.13	1.15038
	grb2-related adaptor protein. [swissprot;acc:q13588]	Ranked	223.457	207.222	1.07835
442	centromere protein j; centrosomal p4.1-associated protein; lyst-interacting protein lip1; lag-3-associated protein. [refseq;acc:nm_018451]	Squared	51286.6	42334.5	1.21146
	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	Ranked	223.802	207.55	1.0783
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	Measured	6251.99	7192.17	1.15038
	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]	Rooted	63.2134	69.352	1.09711
443	60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025]		50.1766	45.7369	1.09707
	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	Measured	6252.27	7192.51	1.15038
	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	Ranked	223.79	207.539	1.0783
	translation initiation factor if-2, mitochondrial precursor (if-2mt) (if-2(mt)). [swissprot;acc:p46199]	Squared	26472.8	32067.7	1.21135
444	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	Rooted	50.1636	45.7275	1.09701
	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	Ranked	223.801	207.549	1.0783
	probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848]	Measured	3758.67	4322.87	1.15011
	ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	Squared	58831	48584.2	1.21091
445	ad24 protein. [refseq;acc:nm_022451]	Measured	3753.71	4315.95	1.14978
	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	Ranked	223.801	207.549	1.0783
	ribosomal protein l10-like protein. [refseq;acc:nm_080746]	Rooted	50.1635	45.7274	1.09701
	ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]	Squared	58831	48584.2	1.21091
446	eukaryotic translation initiation factor 4e (eif-4e) (eif4e) (mrna cap-binding protein) (eif-4f 25 kda subunit). [swissprot;acc:p06730]	Rooted	54.9019	60.2111	1.0967

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.