MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2230 to 2279 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
558	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	Squared	8426.68	10010.8	1.18799
	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	Measured	6167.93	7007.7	1.13615
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	Ranked	135.087	144.041	1.06628
559	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	Squared	8426.68	10010.8	1.18799
	ferritin heavy chain (ferritin h subunit). [swissprot;acc:p02794]	Rooted	62.7397	67.9651	1.08329
	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]	Measured	6167.93	7007.7	1.13615
	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	Ranked	207.309	194.452	1.06612
560	cystathionine beta-synthase (ec 4.2.1.22) (serine sulfhydrase) (beta-thionase). [swissprot;acc:p35520]	Measured	5480.24	6222.04	1.13536
	electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (ec 1.5.5.1) (etf-qo) (etf-ubiquinone oxidoreductase) (etf dehydrogenase) (electron-transferring- flavoprotein dehydrogenase). [swissprot;acc:q16134]	Squared	26334.7	31272.3	1.18749
	putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642]	Rooted	51.0687	47.1439	1.08325
	son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	Ranked	205.74	193.021	1.06589
561	cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]	Rooted	62.7424	67.9648	1.08324
	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]	Ranked	205.89	193.183	1.06578
	transforming protein rhoc (h9). [swissprot;acc:p08134]	Measured	5480.24	6222.04	1.13536
	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	Squared	18240.1	21659.2	1.18745
562	dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6]	Rooted	62.7424	67.9648	1.08324
	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	Squared	25294.9	30027.4	1.18709
	ptb domain adaptor protein ced-6; engulfment adapter protein. [refseq;acc:nm_016315]	Ranked	220.744	207.121	1.06577
	thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [swissprot;acc:q16762]	Measured	5480.24	6222.04	1.13536
563	3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]
	calcyphosine. [swissprot;acc:q13938]	Ranked	220.744	207.121	1.06577
	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	Rooted	62.7424	67.9648	1.08324
	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	Squared	30408.3	36092.8	1.18694
564	cad protein [includes: glutamine-dependent carbamoyl-phosphate synthase (ec 6.3.5.5); aspartate carbamoyltransferase (ec 2.1.3.2); dihydroorotase (ec 3.5.2.3)]. [swissprot;acc:p27708]		25396.2	30143.4	1.18693
	crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]	Ranked	220.744	207.121	1.06577
	putative adenosylhomocysteinase 2 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:o43865]	Rooted	62.7424	67.9648	1.08324
	transforming protein rhoa (h12). [swissprot;acc:p06749]	Measured	5480.24	6222.04	1.13536
565	fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467]	Squared	25287.7	30003.7	1.18649
	limkain b1. [refseq;acc:nm_019081]	Rooted	62.7424	67.9648	1.08324
	sedlin. [swissprot;acc:o14582]	Ranked	129.219	121.261	1.06563
	small glutamine-rich tetratricopeptide repeat-containing protein (vpu-binding protein) (ubp). [swissprot;acc:o43765]	Measured	10434.4	11846.2	1.1353
566	autoantigen ngp-1. [swissprot;acc:q13823]		3766.14	4274.79	1.13506
	putative adenosylhomocysteinase 3 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:q96hn2]	Rooted	62.7424	67.9648	1.08324
	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	Ranked	129.219	121.261	1.06563
	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	Squared	34268.1	40650.4	1.18625
567	bet3 homolog. [swissprot;acc:o43617]	Ranked	129.219	121.261	1.06563
	cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851]	Rooted	62.7424	67.9648	1.08324
	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (ec 3.6.1.23) (dutpase) (dutp pyrophosphatase). [swissprot;acc:p33316]	Measured	10264.9	9043.51	1.13506
	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	Squared	34219.8	40585.4	1.18602
568	disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]	Rooted	62.7424	67.9648	1.08324
	grpe protein homolog 2, mitochondrial precursor (mt-grpe#2). [swissprot;acc:q8taa5]	Measured	4134.77	4691.24	1.13458
	max protein. [swissprot;acc:p25912]	Squared	18764.5	22255	1.18602
	putative pre-mrna splicing factor rna helicase (atp-dependent rna helicase #3) (deah-box protein 16). [swissprot;acc:o60231]	Ranked	226.3	212.38	1.06554
569	grpe protein homolog 1, mitochondrial precursor (mt-grpe#1) (hmge). [swissprot;acc:q9hav7]	Measured	4134.77	4691.24	1.13458
	kininogen precursor (alpha-2-thiol proteinase inhibitor) [contains: bradykinin]. [swissprot;acc:p01042]	Rooted	62.7424	67.9648	1.08324
	t-complex associated-testis-expressed 1-like (protein 91/23). [swissprot;acc:p51808]	Squared	52623.3	44380.3	1.18574
	t54 protein. [swissprot;acc:q92917]	Ranked	226.3	212.38	1.06554
570	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	Rooted	62.7424	67.9648	1.08324
	double-strand break repair protein mre11a (mre11 homolog 1). [swissprot;acc:p49959]	Squared	52623.3	44380.3	1.18574
	splicing factor arginine/serine-rich 11 (arginine-rich 54 kda nuclear protein) (p54). [swissprot;acc:q05519]	Ranked	229.709	215.631	1.06529

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.