MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1751 to 1800 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
876	5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131]	Divided	212.002	203.954	1.03946
	tax interaction protein 1. [refseq;acc:nm_014604]	Subtracted	223.906	215.653	8.253
877	5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741]	Divided	212.002	203.954	1.03946
	zinc finger protein 444; endothelial zinc finger protein 2. [refseq;acc:nm_018337]	Subtracted	269.896	278.093	8.197
878	5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	Divided	212.002	203.954	1.03946
	syntaxin 7. [swissprot;acc:o15400]	Subtracted	217.181	209.012	8.169
879	5'-amp-activated protein kinase, beta-1 subunit (ampk beta-1 chain) (ampkb). [swissprot;acc:q9y478]	Divided	212.002	203.954	1.03946
	phenylalanyl-trna synthetase alpha chain (ec 6.1.1.20) (phenylalanine- -trna ligase alpha chain) (phers) (cml33). [swissprot;acc:q9y285]	Subtracted	217.491	209.323	8.168
880	5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]	Divided	212.002	203.954	1.03946
	phenylalanine-trna synthetase. [refseq;acc:nm_006567]	Subtracted	217.491	209.323	8.168
881	l-myc-1 proto-oncogene protein. [swissprot;acc:p12524]	Divided	227.604	219.001	1.03928
	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	Subtracted	211.961	203.814	8.147
882	mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388]		198.781	190.66	8.121
	n-myc proto-oncogene protein. [swissprot;acc:p04198]	Divided	227.601	219.008	1.03924
883	ga binding protein alpha chain (gabp-alpha subunit) (transcription factor e4tf1-60) (nuclear respiratory factor-2 subunit alpha). [swissprot;acc:q06546]		227.596	219.017	1.03917
	peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855]	Subtracted	198.781	190.66	8.121
884	ga binding protein beta-2 chain (gabp-beta-2 subunit) (transcription factor e4tf1-47) (gapbp-2) (nuclear respiratory factor-2 subunit gamma). [swissprot;acc:q06545]	Divided	227.596	219.017	1.03917
	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	Subtracted	232.473	224.372	8.101
885	casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]
	nadh-ubiquinone oxidoreductase 23 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-23kd) (ci-23kd) (tyky subunit). [swissprot;acc:o00217]	Divided	227.596	219.017	1.03917
886	elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60]			219.018
	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	Subtracted	211.908	203.832	8.076
887	5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]		212.002	203.954	8.048
	transducin beta-like 3; wd-repeat protein sazd. [refseq;acc:nm_006453]	Divided	244.155	234.96	1.03913
888	5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	Subtracted	212.002	203.954	8.048
	nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594]	Divided	212.027	204.05	1.03909
889	5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131]	Subtracted	212.002	203.954	8.048
	alpha-nac protein. [sptrembl;acc:q9h009]	Divided	212.028	204.053	1.03908
890	5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741]	Subtracted	212.002	203.954	8.048
	syntaxin 7. [swissprot;acc:o15400]	Divided	217.181	209.012	1.03908
891	5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	Subtracted	212.002	203.954	8.048
	small gtp-binding tumor suppressor 1. [refseq;acc:nm_145173]	Divided	212.028	204.055	1.03907
892	5'-amp-activated protein kinase, beta-1 subunit (ampk beta-1 chain) (ampkb). [swissprot;acc:q9y478]	Subtracted	212.002	203.954	8.048
	di-ras2. [refseq;acc:nm_017594]	Divided	212.028	204.055	1.03907
893	5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]	Subtracted	212.002	203.954	8.048
	myc proto-oncogene protein (c-myc). [swissprot;acc:p01106]	Divided	227.585	219.037	1.03903
894	mitochondrial 60s ribosomal protein l27 (l27mt) (hspc250). [swissprot;acc:q9p0m9]	Subtracted	231.163	239.205	8.042
	phenylalanyl-trna synthetase alpha chain (ec 6.1.1.20) (phenylalanine- -trna ligase alpha chain) (phers) (cml33). [swissprot;acc:q9y285]	Divided	217.491	209.323	1.03902
895	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]	Subtracted	164	155.961	8.039
	phenylalanine-trna synthetase. [refseq;acc:nm_006567]	Divided	217.491	209.323	1.03902
896	dna-directed rna polymerase ii 13.3 kda polypeptide (ec 2.7.7.6) (rpb11). [swissprot;acc:p52435]		230.811	239.785	1.03888
	t-cell activation wd repeat protein. [refseq;acc:nm_139281]	Subtracted	243.34	235.322	8.018
897	3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	Divided	272.878	283.472	1.03882
	prip-interacting protein pipmt; prip-interacting protein with methyltransferase domain. [refseq;acc:nm_024831]	Subtracted	210.863	218.878	8.015
898	60s acidic ribosomal protein p1. [swissprot;acc:p05386]	Divided	229.171	238.048	1.03874
	pdz/coiled-coil domain binding partner for the rho-family gtpase tc10; fused in glioblastoma; golgi associated pdz and coiled-coil motif containing protein; cftr-associated ligand. [refseq;acc:nm_020399]	Subtracted	210.863	218.878	8.015
899	nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594]		212.027	204.05	7.977
	thioredoxin domain-containing 2; sperm-specific thioredoxin; thioredoxin domain-containing 2 (spermatozoa). [refseq;acc:nm_032243]	Divided	229.171	238.048	1.03874
900	alpha-nac protein. [sptrembl;acc:q9h009]	Subtracted	212.028	204.053	7.975
	thioredoxin (atl-derived factor) (adf) (surface associated sulphydryl protein) (sasp). [swissprot;acc:p10599]	Divided	229.171	238.048	1.03874

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.