MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1850 to 1899 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	red	green	network_comparison
925	phenylalanyl-trna synthetase alpha chain (ec 6.1.1.20) (phenylalanine- -trna ligase alpha chain) (phers) (cml33). [swissprot;acc:q9y285]	Low confidence	201.128	196.213	1.02505
926	glutamine synthetase (ec 6.3.1.2) (glutamate--ammonia ligase). [swissprot;acc:p15104]		201.442	196.519
	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	High confidence	217.942	210.139	1.03713
927	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	Low confidence	198.264	193.42	1.02504
	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	High confidence	217.942	210.139	1.03713
928	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]		225.976	218.017	1.03651
	transcription factor etv6 (ets-related protein tel1) (tel) (ets translocation variant 6). [swissprot;acc:p41212]	Low confidence	205.137	200.128	1.02503
929	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]		198.26	193.418
	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	High confidence	225.955	218.015	1.03642
930	protein cgi-140 (protein ptd008) (my006 protein). [swissprot;acc:q9y284]	Low confidence	205.137	200.128	1.02503
	pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618]	High confidence	231.357	239.778	1.0364
931	ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6]		159.13	164.917	1.03637
	transcription factor tel-2 (ets-related protein tel2) (tel related ets factor). [swissprot;acc:q9y603]	Low confidence	205.137	200.128	1.02503
932	fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467]		190.502	185.852	1.02502
	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]	High confidence	225.939	218.013	1.03636
933	basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]		159.165	164.951	1.03635
	dj842g6.2 (novel protein imilar to sel1l (sel-1 (suppressor of lin-12, c.elegans)-like)) (fragment). [sptrembl;acc:q9ugd3]	Low confidence	190.447	185.802	1.025
934	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	High confidence	242.024	233.544	1.03631
	sel-1 homolog precursor (suppressor of lin-12-like protein) (sel-1l). [swissprot;acc:q9ubv2]	Low confidence	190.447	185.803	1.02499
935	immature colon carcinoma transcript 1 (digestion substraction 1) (ds- 1). [swissprot;acc:q14197]		200.801	195.908	1.02498
	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	High confidence	232.473	224.372	1.03611
936	casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]
	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	Low confidence	190.386	185.747	1.02497
937	spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813]		194.236	189.504
	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	High confidence	220.246	212.618	1.03588
938	clathrin coat assembly protein ap180 (clathrin coat associated protein ap180) (91 kda synaptosomal-associated protein). [swissprot;acc:o60641]	Low confidence	203.609	198.648	1.02497
	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	High confidence	220.246	212.618	1.03588
939	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]		216.501	224.27
	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]	Low confidence	206.817	201.78	1.02496
940	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	High confidence	212.442	205.088	1.03586
	vacuolar protein sorting 29 (vesicle protein sorting 29) (hvps29) (mds007) (pep11) (dc7/dc15). [swissprot;acc:q9ubq0]	Low confidence	202.747	197.81	1.02496
941	2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]		207.026	201.99	1.02493
	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	High confidence	212.437	205.083	1.03586
942	grancalcin. [swissprot;acc:p28676]		212.442	205.088
	lin-7 homolog c; lin-7 protein 3. [refseq;acc:nm_018362]	Low confidence	207.862	202.809	1.02492
943	nadh-ubiquinone oxidoreductase sgdh subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-sgdh) (ci-sgdh). [swissprot;acc:o43674]		205.602	200.603
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	High confidence	212.442	205.087	1.03586
944	growth hormone inducible transmembrane protein (dermal papilla derived protein 2) (my021 protein) (ptd010). [swissprot;acc:q9h3k2]	Low confidence	204.752	199.775	1.02491
	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]	High confidence	212.437	205.083	1.03586
945	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]		212.44	205.085
	sedlin. [swissprot;acc:o14582]	Low confidence	195.693	190.937	1.02491
946	histone h4. [swissprot;acc:p02304]	High confidence	227.765	219.902	1.03576
	vacuolar protein sorting-associated protein 45 (h-vps45) (hlvps45). [swissprot;acc:q9nrw7]	Low confidence	204.752	199.775	1.02491
947	ad24 protein. [refseq;acc:nm_022451]		203.472	198.533	1.02488
	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	High confidence	212.51	205.191	1.03567
948	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	Low confidence	209.239	204.165	1.02485
	target of myb protein 1. [swissprot;acc:o60784]	High confidence	217.254	209.824	1.03541
949	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	Low confidence	204.147	199.196	1.02485
	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]	High confidence	217.253	209.826	1.0354
950	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	Low confidence	204.147	199.196	1.02485

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.