MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	description	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 432 to 481 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]	1698	ADSSL1	Subtracted	204.437	201.551	2.886
adenylosuccinate synthetase (ec 6.3.4.4) (imp--aspartate ligase) (adss) (ampsase). [swissprot;acc:p30520]	1665	ADSS	Divided	204.433	201.564	1.01423
	1700		Subtracted			2.869
adenylyl cyclase-associated protein 1 (cap 1). [swissprot;acc:q01518]	1850	CAP1	Divided	215.931	213.587	1.01097
	1852		Subtracted			2.344
adenylyl cyclase-associated protein 2 (cap 2). [swissprot;acc:p40123]	1886	CAP2		215.853	213.639	2.214
	1895		Divided			1.01036
adhesion regulating molecule 1 precursor (110 kda cell membrane glycoprotein) (gp110). [swissprot;acc:q16186]	2356	ADRM1	Subtracted	218.555	219.434	0.879
	2369		Divided			1.00402
adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9]	801	C20orf3	Subtracted	212.386	221.785	9.399
	813		Divided			1.04425
adiponectin receptor 2. [refseq;acc:nm_024551]	119	ADIPOR2	Subtracted	281.582	246.371	35.211
	185		Divided			1.14292
adp,atp carrier protein, fibroblast isoform (adp/atp translocase 2) (adenine nucleotide translocator 2) (ant 2). [swissprot;acc:p05141]	1535	SLC25A5	Subtracted	225.159	221.424	3.735
	1552		Divided			1.01687
adp,atp carrier protein, heart/skeletal muscle isoform t1 (adp/atp translocase 1) (adenine nucleotide translocator 1) (ant 1). [swissprot;acc:p12235]	1533	SLC25A4	Subtracted			3.735
	1551		Divided			1.01687
adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	1532	SLC25A6	Subtracted			3.735
	1550		Divided			1.01687
adp-ribosylation factor 1. [swissprot;acc:p32889]	2110	ARF1	Subtracted	221.248	222.788	1.54
	2128		Divided			1.00696
adp-ribosylation factor 3. [swissprot;acc:p16587]	2112	ARF3	Subtracted			1.54
	2130		Divided			1.00696
adp-ribosylation factor 4. [swissprot;acc:p18085]	2105	ARF4	Subtracted			1.54
	2123		Divided			1.00696
adp-ribosylation factor gtpase activating protein 1 (adp-ribosylation factor 1 gtpase activating protein) (arf1 gap) (arf1-directed gtpase- activating protein) (gap protein). [swissprot;acc:q8n6t3]	2156	ARFGAP1		200.063	198.71	1.00681
	2219		Subtracted			1.353
adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	2116	ARFGAP3		221.248	222.788	1.54
	2137		Divided			1.00696
adp-ribosylation factor-like protein 1. [swissprot;acc:p40616]	2613	ARL1		215.497	215.799	1.0014
	2623		Subtracted			0.302
adp-ribosylation factor-like protein 3. [swissprot;acc:p36405]	2517	ARL3		215.835	216.341	0.506
	2520		Divided			1.00234
adp-ribosylation factor-like protein 4. [swissprot;acc:p40617]	1163	ARL4A	Subtracted	218.402	212.904	5.498
	1188		Divided			1.02582
adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]	1161	no value	Subtracted			5.498
	1186		Divided			1.02582
adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]	1105	FDX1		191.139	185.882	1.02828
	1226		Subtracted			5.257
af-6 protein. [swissprot;acc:p55196]	1528	MLLT4		218.733	214.98	3.753
	1530		Divided			1.01746
afg3-like protein 2 (ec 3.4.24.-) (paraplegin-like protein). [swissprot;acc:q9y4w6]	1709	AFG3L2	Subtracted	217.676	220.53	2.854
	1725		Divided			1.01311
aflatoxin b1 aldehyde reductase 1 (ec 1.-.-.-) (afb1-ar 1) (aldoketoreductase 7). [swissprot;acc:o43488]	1938	AKR7A2	Subtracted	211.633	213.703	2.07
	1969		Divided			1.00978
aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]	1928	AKR7A3	Subtracted			2.07
	1958		Divided			1.00978
ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]	1075	AIP	Subtracted	224.307	230.242	5.935
	1157		Divided			1.02646
alanine aminotransferase (ec 2.6.1.2) (glutamic--pyruvic transaminase) (gpt) (glutamic--alanine transaminase). [swissprot;acc:p24298]	2025	GPT		189.987	191.668	1.00885

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.