MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	Value Type	red	description	Interaction Map	Network Comparison Type	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 3228 in total

Value Type  : Ranked
Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1

Rank	red	description	green	network_comparison
51	133	spermatogenesis associated 6. [refseq;acc:nm_019073]	105	1.26667
52		amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
53	201.144	transcription factor jun-b. [swissprot;acc:p17275]	158.868	1.26611
54	200.941	transcription factor jun-d. [swissprot;acc:p17535]	158.941	1.26425
55	320.927	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	254.434	1.26134
56	266.856	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	336.233	1.25998
57		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]
58	266.863	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	336.191	1.25979
59		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	336.19	1.25978
60	266.864	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	336.184	1.25976
61		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	336.182	1.25975
62	266.865	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	336.181	1.25974
63		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	336.178	1.25973
64	266.868	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	336.159	1.25965
65	267.136	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	336.077	1.25807
66		guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]
67	267.14	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	336.075	1.25805
68	267.139	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]
69	267.14	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]
70	267.142	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	336.074	1.25804
71	267.144	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	336.073	1.25802
72		guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]
73	288	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	362	1.25694
74		junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]
75		sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]
76		db83 protein. [swissprot;acc:p57088]
77	254.692	voltage-dependent calcium channel gamma-2 subunit (neuronal voltage- gated calcium channel gamma-2 subunit). [swissprot;acc:q9y698]	202.668	1.2567
78	254.693	voltage-dependent calcium channel gamma-8 subunit (neuronal voltage- gated calcium channel gamma-8 subunit). [swissprot;acc:q8wxs5]
79		voltage-dependent calcium channel gamma-3 subunit (neuronal voltage- gated calcium channel gamma-3 subunit). [swissprot;acc:o60359]
80	254.691	voltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit). [swissprot;acc:q9ubn1]		1.25669
81	254.614	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	202.646	1.25645
82	267.636	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	335.359	1.25304
83	88.2482	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	110.265	1.24949
84		hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]
85		melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]
86		melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]
87		melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]
88		hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]
89		melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]
90		necdin. [swissprot;acc:q99608]
91		melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]
92		melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]
93		melanoma antigen, family b, 6. [refseq;acc:nm_173523]
94		melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]
95		melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]
96		melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]
97		melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]
98		melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]
99		melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]
100		melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.