MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 158 to 207 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Value Type	description	red	green	network_comparison
40	FCN2	Ranked	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	322	253	1.27273
	GNAI1	Measured	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	1836.81	907.978	2.02297
		Rooted		40.2797	24.3705	1.65281
41	no value	Ranked	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	322	253	1.27273
	GNAI3	Measured	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	1836.81	907.978	2.02297
		Rooted		40.2797	24.3705	1.65281
	MAP1LC3B	Squared	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	144912	81155	1.78562
42	FOS	Ranked	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	204.641	160.957	1.2714
	GNB5	Measured	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	1857.32	958.237	1.93827
		Rooted		40.225	24.7051	1.62821
	MAP1LC3A	Squared	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	144911	81154.7	1.78561
43	no value	Ranked	jun dimerization protein. [refseq;acc:nm_130469]	204.641	160.957	1.2714
	ATG4B	Squared	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	144876	81136.5	1.78558
	GNB1	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	40.6302	25.4452	1.59677
	GNB3	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	1881.02	1027.36	1.83093
44	FOSL2	Ranked	fos-related antigen 2. [swissprot;acc:p15408]	204.641	161.046	1.2707
	GABARAP	Squared	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	139741	78454.6	1.78117
	GNB1	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	1931.34	1057.39	1.82652
	GNB4	Rooted	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	40.5691	25.4263	1.59556
45	no value	Squared	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	129597	73157.5	1.77148
	FOSB	Ranked	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	204.641	161.051	1.27066
	GNB3	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	40.081	25.1546	1.59339
	GNB4	Measured	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	1926.69	1056.02	1.82448
46	ATG3	Squared	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	129597	73157.5	1.77148
	DTX2	Rooted	deltex 2. [refseq;acc:nm_020892]	27.634	43.9629	1.5909
	FOSL1	Ranked	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	204.642	161.068	1.27053
	NEUROD2	Measured	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	779.167	1390.33	1.78438
47	no value	Squared	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	98517.9	56927.2	1.73059
	CHD3	Measured	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	779.167	1390.33	1.78438
	DTX1	Rooted	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	27.7078	44.017	1.58861
	TMEM132A	Ranked	gbp protein isoform a. [refseq;acc:nm_017870]	325.586	256.492	1.26938
48	CDK2AP2	Measured	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	779.167	1390.33	1.78438
	GABARAP	Ranked	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	65.4586	83.0461	1.26868
	LASS2	Squared	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	6300.2	10703.5	1.69891
	PBK	Rooted	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	27.7254	44.0299	1.58807
49	ARRB2	Ranked	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	133	105	1.26667
	KHDRBS3	Rooted	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	27.7254	44.0299	1.58807
	NEUROD6	Measured	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	779.167	1390.33	1.78438
	STAMBPL1	Squared	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	28994.2	17134.8	1.69212
50	ARRB1	Ranked	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	133	105	1.26667
	CHMP2A	Squared	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	28994.2	17134.8	1.69212
	KHDRBS1	Rooted	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	27.7254	44.0299	1.58807
	NEUROD1	Measured	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	779.167	1390.33	1.78438
51	KHDRBS2	Rooted	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	27.7254	44.0299	1.58807
	NEUROD4	Measured	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]	779.167	1390.33	1.78438
	SPATA6	Ranked	spermatogenesis associated 6. [refseq;acc:nm_019073]	133	105	1.26667
	STAMBP	Squared	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	28994.2	17134.8	1.69212
52	AMPD2	Ranked	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	133	105	1.26667
	CHD5	Measured	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	779.167	1390.33	1.78438
	NEURL	Rooted	neuralized-like. [refseq;acc:nm_004210]	27.9107	44.1656	1.58239

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.