MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Interaction Map	Network Comparison Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1225 to 1274 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	Network Comparison Type	red	green	network_comparison
154	Measured	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Divided	23693.7	18263	1.29736
		myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	Subtracted	9035	7279.6	1755.4
	Ranked	musashi 2 isoform a. [refseq;acc:nm_138962]		227.491	199.458	28.033
		regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Divided	249.663	298.263	1.19466
	Squared	solute carrier family 4 (anion exchanger), member 1, adaptor protein; kidney anion exchanger adaptor protein; kanadaptin; lung cancer oncogene 3. [refseq;acc:nm_018158]	Subtracted	70525.9	52678.7	17847.2
		t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	Divided	42788.3	60162.6	1.40605
	Rooted	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]		43.5479	51.5473	1.18369
		homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	Subtracted	50.339	62.9975	12.6585
155	Measured	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Divided	23693.7	18263	1.29736
		myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	Subtracted	9035	7279.6	1755.4
	Ranked	musashi 1. [refseq;acc:nm_002442]		227.491	199.458	28.033
		putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Divided	249.663	298.263	1.19466
	Squared	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]		126408	89940.5	1.40546
		cyclin-dependent kinases regulatory subunit 2 (cks-2). [swissprot;acc:p33552]	Subtracted	70525.9	52678.7	17847.2
	Rooted	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]		54.2343	66.7323	12.498
		small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Divided	55.7423	65.6839	1.17835
156	Measured	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]		23693.7	18263	1.29736
		myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	Subtracted	9035	7279.6	1755.4
	Ranked	nuclear protein ukp68. [refseq;acc:nm_024824]		227.491	199.458	28.033
		regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	Divided	249.663	298.263	1.19466
	Squared	catenin (cadherin-associated protein), alpha-like 1; alpha-catulin. [refseq;acc:nm_003798]	Subtracted	70525.9	52678.7	17847.2
		septin 10 isoform 1. [refseq;acc:nm_144710]	Divided	89578.7	125883	1.40528
	Rooted	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Subtracted	55.1026	67.5701	12.4675
		sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	Divided	56.3447	66.124	1.17356
157	Measured	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]		23693.7	18263	1.29736
		myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Subtracted	9035	7279.6	1755.4
	Ranked	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]		312	284	28
		transcription factor lbx1. [swissprot;acc:p52954]	Divided	249.663	298.263	1.19466
	Squared	brain protein 44. [swissprot;acc:o95563]		89182.8	125229	1.40418
		huntingtin interacting protein 1 (hip-i). [swissprot;acc:o00291]	Subtracted	76438	58889.7	17548.3
	Rooted	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	Divided	52.7582	61.9123	1.17351
		huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Subtracted	55.1113	67.5537	12.4424
158	Measured	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Divided	23693.7	18263	1.29736
		myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Subtracted	9035	7279.6	1755.4
	Ranked	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]		312	284	28
		mosaic protein lgn. [swissprot;acc:p81274]	Divided	249.663	298.263	1.19466
	Squared	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]	Subtracted	76360.8	58841.7	17519.1
		septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Divided	89182.8	125229	1.40418
	Rooted	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]		56.3507	66.1252	1.17346
		protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	Subtracted	149.397	136.972	12.425
159	Measured	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]		9035	7279.6	1755.4
		necdin. [swissprot;acc:q99608]	Divided	23693.7	18263	1.29736
	Ranked	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	Subtracted	312	284	28
		regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	Divided	249.663	298.263	1.19466
	Squared	huntingtin interacting protein 1 related (hip1-related) (hip 12). [swissprot;acc:o75146]	Subtracted	76296.4	58801.6	17494.8
		septin 6. [swissprot;acc:q14141]	Divided	88953.6	124854	1.40359
	Rooted	rna-binding protein. [refseq;acc:nm_019027]		52.7642	61.9019	1.17318
		ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	Subtracted	113.983	101.979	12.004
160	Measured	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]		9035	7279.6	1755.4
		melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Divided	23693.7	18263	1.29736

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.