MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2154 to 2203 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
1077	translationally controlled tumor protein (tctp) (p23) (histamine- releasing factor) (hrf). [swissprot;acc:p13693]	Subtracted	218.098	212.209	5.889
1078	interleukin enhancer-binding factor 1 (cellular transcription factor ilf-1). [swissprot;acc:q01167]		218.006	212.119	5.887
	peptidyl-prolyl cis-trans isomerase e (ec 5.2.1.8) (ppiase e) (rotamase e) (cyclophilin e) (cyclophilin 33). [swissprot;acc:q9unp9]	Divided	174.387	179.697	1.03045
1079	coatomer zeta-2 subunit (zeta-2 coat protein) (zeta-2 cop). [swissprot;acc:q9p299]
	homeobox protein six1 (sine oculis homeobox homolog 1). [swissprot;acc:q15475]	Subtracted	221.286	215.399	5.887
1080	proliferation-associated protein 2g4 (cell cycle protein p38-2g4 homolog) (hg4-1). [swissprot;acc:q9uq80]		221.285	215.4	5.885
	zinc finger protein 444; endothelial zinc finger protein 2. [refseq;acc:nm_018337]	Divided	269.896	278.093	1.03037
1081	40s ribosomal protein s30. [swissprot;acc:q05472]		223.44	216.875	1.03027
	homeobox protein six2 (sine oculis homeobox homolog 2). [swissprot;acc:q9npc8]	Subtracted	221.285	215.401	5.884
1082	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]		209.052	203.183	5.869
	phafin 2; ph and fyve domain-containing protein 2. [refseq;acc:nm_024613]	Divided	220.118	213.685	1.03011
1083	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]
	apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	Subtracted	217.99	212.123	5.867
1084	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	Divided	220.118	213.685	1.03011
	vacuolar proton translocating atpase 116 kda subunit a isoform 1 (clathrin-coated vesicle/synaptic vesicle proton pump 116 kda subunit) (vacuolar proton pump subunit 1) (vacuolar adenosine triphosphatase subunit ac116). [swissprot;acc:q93050]	Subtracted	218.529	212.676	5.853
1085	dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832]	Divided	231.007	237.864	1.02968
	vacuolar proton translocating atpase 116 kda subunit a isoform 2 (v-atpase 116-kda isoform a2) (tj6). [swissprot;acc:q9y487]	Subtracted	218.528	212.676	5.852
1086	atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632]
	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	Divided	236.679	243.679	1.02958
1087	vacuolar proton translocating atpase 116 kda subunit a isoform 3 (v- atpase 116-kda isoform a3) (osteoclastic proton pump 116 kda subunit) (oc-116 kda) (oc116) (t-cell immune regulator 1) (t cell immune response cdna7 protein) (tirc7). [swissprot;acc:q13488]	Subtracted	218.527	212.676	5.851
	zinc finger protein 277. [swissprot;acc:q9nrm2]	Divided	236.679	243.679	1.02958
1088	annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]		219.673	213.378	1.0295
	pxr2b protein. [refseq;acc:nm_016559]	Subtracted	212.945	207.109	5.836
1089	atpase, h+ transporting, lysosomal 38kda, v0 subunit d isoform 2. [refseq;acc:nm_152565]		218.487	212.656	5.831
	cleavage stimulation factor subunit 3; cleavage stimulation factor, 3' pre-rna, subunit 3, 77kd. [refseq;acc:nm_001326]	Divided	121.428	125.004	1.02945
1090	neurocalcin delta. [swissprot;acc:p29554]	Subtracted	225.104	230.931	5.827
	similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9]	Divided	226.218	232.88	1.02945
1091	block 23. [sptrembl;acc:q8nhw5]		226.205	232.858	1.02941
	neuron specific calcium-binding protein hippocalcin (p23k) (calcium- binding protein bdr-2). [swissprot;acc:p32076]	Subtracted	225.103	230.928	5.825
1092	60s acidic ribosomal protein p0 (l10e). [swissprot;acc:p05388]	Divided	226.203	232.855	1.02941
	visinin-like protein 3 (vilip-3) (calcium-binding protein bdr-1) (hlp2) (hippocalcin-like protein 1). [swissprot;acc:p37235]	Subtracted	225.094	230.913	5.819
1093	coatomer alpha subunit (alpha-coat protein) (alpha-cop) (hepcop) (hep-cop) [contains: xenin (xenopsin-related peptide); proxenin]. [swissprot;acc:p53621]	Divided	177.432	182.647	1.02939
	vacuolar atp synthase subunit g 2 (ec 3.6.3.14) (v-atpase g subunit 2) (vacuolar proton pump g subunit 2) (v-atpase 13 kda subunit 2). [swissprot;acc:o95670]	Subtracted	218.484	212.675	5.809
1094	annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	Divided	219.655	213.385	1.02938
	apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]	Subtracted	218.484	212.675	5.809
1095	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	Divided	213.552	207.463	1.02935
	sec13-related protein. [swissprot;acc:p55735]	Subtracted	218.484	212.675	5.809
1096	nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9]	Divided	212.345	206.339	1.02911
	vacuolar atp synthase subunit g 3 (ec 3.6.3.14) (v-atpase g subunit 3) (vacuolar proton pump g subunit 3) (v-atpase 13 kda subunit 3). [swissprot;acc:q96lb4]	Subtracted	218.484	212.675	5.809
1097	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]	Divided	209.123	203.208	1.02911
	vacuolar atp synthase subunit b, brain isoform (ec 3.6.3.14) (v-atpase b2 subunit) (vacuolar proton pump b isoform 2) (endomembrane proton pump 58 kda subunit) (ho57). [swissprot;acc:p21281]	Subtracted	218.484	212.675	5.809
1098	adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2]	Divided	217.323	211.185	1.02906
	yeast sec31p homolog. [refseq;acc:nm_014933]	Subtracted	218.484	212.675	5.809
1099	adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]	Divided	217.315	211.183	1.02904
	vacuolar atp synthase subunit g 1 (ec 3.6.3.14) (v-atpase g subunit 1) (vacuolar proton pump g subunit 1) (v-atpase 13 kda subunit 1) (vacuolar atp synthase subunit m16). [swissprot;acc:o75348]	Subtracted	218.484	212.675	5.809
1100	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]	Divided	209.052	203.183	1.02889
	vacuolar atp synthase subunit e (ec 3.6.3.14) (v-atpase e subunit) (vacuolar proton pump e subunit) (v-atpase 31 kda subunit) (p31). [swissprot;acc:p36543]	Subtracted	218.484	212.675	5.809
1101	ganglioside-induced differentiation-associated protein 1-like 1. [refseq;acc:nm_024034]
	lysyl-trna synthetase (ec 6.1.1.6) (lysine--trna ligase) (lysrs). [swissprot;acc:q15046]	Divided	220.291	226.584	1.02857
1102	40s ribosomal protein s27 (metallopan-stimulin 1) (mps-1). [swissprot;acc:p42677]		229.442	235.974	1.02847

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.