MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1108 to 1157 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
554	NUTF2	nuclear transport factor 2 (ntf-2) (placental protein 15) (pp15). [swissprot;acc:p13662]	Low confidence	205.57	199.279	1.03157
555	CDC40	pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]		201.554	195.387	1.03156
	FGR	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	High confidence	207.26	194.346	1.06645
556	CUTL1	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]		207.27	194.368	1.06638
	MOBKL3	preimplantation protein 3; likely ortholog of preimplantation protein 3. [refseq;acc:nm_015387]	Low confidence	206.737	200.417	1.03153
557	CUTL2	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	High confidence	207.272	194.371	1.06637
	DNAJB11	dnaj homolog subfamily b member 11 precursor (er-associated dnaj protein 3) (erj3) (er-associated hsp40 co-chaperone) (hdj9) (pwp1- interacting protein 4). [swissprot;acc:q9ubs4]	Low confidence	206.737	200.417	1.03153
558	no value	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	High confidence	135.087	144.041	1.06628
	HTATSF1	hiv tat specific factor 1; cofactor required for tat activation of hiv-1 transcription. [refseq;acc:nm_014500]	Low confidence	209.347	202.978	1.03138
559	SSRP1	structure-specific recognition protein 1 (ssrp1) (recombination signal sequence recognition protein) (t160) (chromatin-specific transcription elongation factor 80 kda subunit) (fact 80 kda subunit). [swissprot;acc:q08945]		205.184	198.948	1.03134
	WASL	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	High confidence	207.309	194.452	1.06612
560	GYG2	glycogenin-2 (ec 2.4.1.186) (gn-2) (gn2). [swissprot;acc:o15488]	Low confidence	199.227	193.173	1.03134
	SOS1	son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	High confidence	205.74	193.021	1.06589
561	ATP9A	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	Low confidence	202.845	209.189	1.03128
	SOS2	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]	High confidence	205.89	193.183	1.06578
562	ECHS1	enoyl-coa hydratase, mitochondrial precursor (ec 4.2.1.17) (short chain enoyl-coa hydratase) (sceh) (enoyl-coa hydratase 1). [swissprot;acc:p30084]	Low confidence	203.367	197.208	1.03123
	GULP1	ptb domain adaptor protein ced-6; engulfment adapter protein. [refseq;acc:nm_016315]	High confidence	220.744	207.121	1.06577
563	CAPS	calcyphosine. [swissprot;acc:q13938]
	CYP4F8	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]	Low confidence	203.155	197.018	1.03115
564	COX15	cox15 homolog isoform 2 precursor; cytochrome c oxidase subunit 15; cytochrome c oxidase assembly protein. [refseq;acc:nm_004376]		203.197	197.076	1.03106
	CRNKL1	crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]	High confidence	220.744	207.121	1.06577
565	CYP4F12	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	Low confidence	203.157	197.064	1.03092
	ZNF547	sedlin. [swissprot;acc:o14582]	High confidence	129.219	121.261	1.06563
566	no value	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]
	MAK	serine/threonine-protein kinase mak (ec 2.7.1.-) (male germ cell- associated kinase). [swissprot;acc:p20794]	Low confidence	168.935	163.869	1.03091
567	ANP32C	acidic leucine-rich nuclear phosphoprotein 32 family member c (tumorigenic protein pp32r1). [swissprot;acc:o43423]		206.46	200.275	1.03088
	TRAPPC3	bet3 homolog. [swissprot;acc:o43617]	High confidence	129.219	121.261	1.06563
568	no value	dj470l14.3 (novel protein similar to the arp2/3 protein complex subunit p21-arc (arc21)). [sptrembl;acc:q9h5b6]	Low confidence	202.86	196.783	1.03088
		putative pre-mrna splicing factor rna helicase (atp-dependent rna helicase #3) (deah-box protein 16). [swissprot;acc:o60231]	High confidence	226.3	212.38	1.06554
569	ANP32A	acidic leucine-rich nuclear phosphoprotein 32 family member a (potent heat-stable protein phosphatase 2a inhibitor i1pp2a) (hla-dr associated protein i) (phapi) (acidic nuclear phosphoprotein pp32) (cerebellar leucine rich acidic nuclear protein). [swissprot;acc:p39687]	Low confidence	206.46	200.275	1.03088
	GPKOW	t54 protein. [swissprot;acc:q92917]	High confidence	226.3	212.38	1.06554
570	ANP32D	acidic leucine-rich nuclear phosphoprotein 32 family member d (tumorigenic protein pp32r2). [swissprot;acc:o95626]	Low confidence	206.46	200.275	1.03088
	SFRS11	splicing factor arginine/serine-rich 11 (arginine-rich 54 kda nuclear protein) (p54). [swissprot;acc:q05519]	High confidence	229.709	215.631	1.06529
571	MDH2	malate dehydrogenase, mitochondrial precursor (ec 1.1.1.37). [swissprot;acc:p40926]		238.529	254.099	1.06528
	USO1	general vesicular transport factor p115 (transcytosis associated protein) (tap) (vesicle docking protein). [swissprot;acc:o60763]	Low confidence	206.46	200.275	1.03088
572	no value	cbf1 interacting corepressor. [refseq;acc:nm_004882]	High confidence	227.86	213.945	1.06504
	ANP32B	acidic leucine-rich nuclear phosphoprotein 32 family member b (phapi2 protein) (silver-stainable protein ssp29) (acidic protein rich in leucines). [swissprot;acc:q92688]	Low confidence	206.46	200.275	1.03088
573	BRD8	bromodomain containing 8; thyroid hormone receptor coactivating protein; skeletal muscle abundant protein. [refseq;acc:nm_006696]
	GPATCH1	evolutionarily conserved g-patch domain containing. [refseq;acc:nm_018025]	High confidence	227.86	213.945	1.06504
574	MOBKL3	preimplantation protein 3; likely ortholog of preimplantation protein 3. [refseq;acc:nm_015387]		221.807	208.264	1.06503
	NRD1	nardilysin precursor (ec 3.4.24.61) (n-arginine dibasic convertase) (nrd convertase) (nrd-c). [swissprot;acc:o43847]	Low confidence	202.855	196.78	1.03087
575	ARPC3	arp2/3 complex 21 kda subunit (p21-arc) (actin-related protein 2/3 complex subunit 3). [swissprot;acc:o15145]		202.85	196.777	1.03086
	DNAJB11	dnaj homolog subfamily b member 11 precursor (er-associated dnaj protein 3) (erj3) (er-associated hsp40 co-chaperone) (hdj9) (pwp1- interacting protein 4). [swissprot;acc:q9ubs4]	High confidence	221.807	208.264	1.06503
576	no value	dj408b20.3 (novel protein similar to 60s acidic ribosomal protein p2 (rplp2)). [sptrembl;acc:q9h5a9]		235.18	250.419	1.0648
	ICK	intestinal cell kinase isoform a; mak-related kinase; serine/threonine protein kinase. [refseq;acc:nm_014920]	Low confidence	169.097	164.039	1.03083
577	ATP6V0C	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]		207.131	200.94	1.03081
	PRSS7	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	High confidence	224.606	210.944	1.06477
578	CNN1	calponin h1, smooth muscle (basic calponin) (calponin 1). [swissprot;acc:p51911]	Low confidence	202.382	196.335	1.0308
	SF3B2	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	High confidence	224.606	210.944	1.06477
579	CNN3	calponin, acidic isoform (calponin 3). [swissprot;acc:q15417]	Low confidence	202.382	196.335	1.0308

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.