MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 801 to 850 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
aspartyl-trna synthetase (ec 6.1.1.12) (aspartate--trna ligase) (asprs). [swissprot;acc:p14868]	2042	DARS	Low confidence	200.776	196.962	1.01936
	2541		High confidence	194.505	194.902	1.00204
associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	126	STAMBPL1		94	114	1.21277
	181		Low confidence	196.362	206.979	1.05407
associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	128	STAMBP	High confidence	94	114	1.21277
	186		Low confidence	196.381	206.921	1.05367
ataxia telangiectasia and rad3 related protein; rad3 related protein; frap-related protein-1; protein kinase atr; seckel syndrome. [refseq;acc:nm_001184]	2766	ATR		201.497	198.046	1.01743
ataxin 2 related protein isoform a; ataxin-2 domain protein. [refseq;acc:nm_007245]	1058	ATXN2L	High confidence	228.105	221.293	1.03078
	1945		Low confidence	199.833	195.982	1.01965
ataxin 2-binding protein. [swissprot;acc:q9nwb1]	1704	no value	High confidence	218.514	215.577	1.01362
	2699		Low confidence	203.718	200.202	1.01756
ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	1059		High confidence	228.105	221.293	1.03078
	1946		Low confidence	199.833	195.982	1.01965
ataxin-1 ubiquitin-like interacting protein. [refseq;acc:nm_020131]	1315	UBQLN4		206.697	202.196	1.02226
	2041		High confidence	196.808	195.141	1.00854
atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	28	no value	Low confidence	142	170	1.19718
	149		High confidence
atp synthase alpha chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p25705]	1658	ATP5A1		217.925	214.826	1.01443
	2577		Low confidence	199.913	196.381	1.01799
atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539]	241	ATP5F1	High confidence	227.357	254.15	1.11785
	2539		Low confidence	197.562	194.049	1.0181
atp synthase beta chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p06576]	1655	ATP5B	High confidence	219.062	215.942	1.01445
	2749		Low confidence	201.597	198.138	1.01746
atp synthase coupling factor 6, mitochondrial precursor (ec 3.6.3.14) (f6). [swissprot;acc:p18859]	972	ATP5J		202.474	197.597	1.02468
	2893		High confidence	0.00001	0.00001	1
atp synthase coupling factor b, mitochondrial precursor. [swissprot;acc:q99766]	2022	ATP5S		208.601	210.464	1.00893
	2992		Low confidence	199.377	196.092	1.01675
atp synthase d chain, mitochondrial (ec 3.6.3.14) (my032 protein). [swissprot;acc:o75947]	3325	ATP5H		195.243	192.242	1.01561
atp synthase delta chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p30049]	1687	ATP5D	High confidence	215.345	212.386	1.01393
	1778		Low confidence	201.399	197.407	1.02022
atp synthase e chain, mitochondrial (ec 3.6.3.14). [swissprot;acc:p56385]	3678	ATP5I		200.518	203.295	1.01385
atp synthase f chain, mitochondrial (ec 3.6.3.14). [swissprot;acc:p56134]	1880	ATP5J2		202.925	198.978	1.01984
	2644		High confidence	194.097	194.328	1.00119
atp synthase g chain, mitochondrial (ec 3.6.3.14) (atpase subunit g). [swissprot;acc:o75964]	2834	ATP5L		0.00001	0.00001	1
	3463		Low confidence	202.723	199.708	1.0151
atp synthase gamma chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p36542]	1563	ATP5C1	High confidence	218.277	214.739	1.01648
	2102		Low confidence	200.038	196.262	1.01924
atp synthase lipid-binding protein, mitochondrial precursor (ec 3.6.3.14) (atp synthase proteolipid p1) (atpase protein 9) (atpase subunit c). [swissprot;acc:p05496]	4006	ATP5G1		201.708	199.381	1.01167
atp synthase lipid-binding protein, mitochondrial precursor (ec 3.6.3.14) (atp synthase proteolipid p2) (atpase protein 9) (atpase subunit c). [swissprot;acc:q06055]	4020	ATP5G2		201.656	199.349	1.01157
atp synthase lipid-binding protein, mitochondrial precursor (ec 3.6.3.14) (atp synthase proteolipid p3) (atpase protein 9) (atpase subunit c). [swissprot;acc:p48201]	4019	ATP5G3		201.68	199.371	1.01158
atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]	456	ATPAF2	High confidence	210.225	226.578	1.07779
	3456		Low confidence	202.709	199.686	1.01514
atp synthase oligomycin sensitivity conferral protein, mitochondrial precursor (ec 3.6.3.14) (oscp). [swissprot;acc:p48047]	1564	ATP5O	High confidence	218.277	214.739	1.01648
	3120		Low confidence	193.258	190.14	1.0164
atp-binding cassette sub-family e member 1 (rnase l inhibitor) (ribonuclease 4 inhibitor) (rns4i) (huhp68). [swissprot;acc:q96b10]	1404	ABCE1		202.268	197.939	1.02187
atp-binding cassette, sub-family c, member 10; multidrug resistance-associated protein 7. [refseq;acc:nm_033450]	2209	ABCC10	High confidence	199.129	200.413	1.00645
	4597		Low confidence	204.498	203.022	1.00727
atp-binding cassette, sub-family d, member 2 (adrenoleukodystrophy related protein) (haldr) (adrenoleukodystrophy-like 1). [swissprot;acc:q9ubj2]	1583	ABCD2		202.41	206.669	1.02104
atp-binding cassette, sub-family d, member 3 (70 kda peroxisomal membrane protein) (pmp70). [swissprot;acc:p28288]	2166	ABCD3	High confidence	215.925	214.481	1.00673
	4280		Low confidence	202.428	204.33	1.0094

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.