MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison	Value Type

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Showing element 51 to 100 of 16578 in total

Filtered  : 1
Value Type  : Ranked

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
13	UFC1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Divided	High confidence	288.754	212.554	1.3585
			Subtracted	Low confidence	255.046	202.362	52.684
14	ATG4A	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	Divided	High confidence	56.6768	75.3531	1.32952
	BEST2	vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]		Low confidence	37.9984	29.1831	1.30207
	CYP27B1	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	Subtracted		286.396	238.476	47.92
	GNG4	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]		High confidence	266.863	336.191	69.328
15	CYP27A1	cytochrome p450 27, mitochondrial precursor (ec 1.14.-.-) (cytochrome p-450c27/25) (sterol 26-hydroxylase) (sterol 27-hydroxylase) (vitamin d(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase). [swissprot;acc:q02318]		Low confidence	286.347	238.454	47.893
	GNG3	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]		High confidence	266.863	336.19	69.327
	MAP1LC3B	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	Divided		56.7244	75.3948	1.32914
	UFC1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]		Low confidence	255.046	202.362	1.26035
16	CYP24A1	cytochrome p450 24a1, mitochondrial precursor (ec 1.14.-.-) (p450- cc24) (vitamin d(3) 24-hydroxylase) (1,25-dihydroxyvitamin d(3) 24- hydroxylase) (24-ohase). [swissprot;acc:q07973]	Subtracted		284.798	237.743	47.055
	GNG8	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]		High confidence	266.864	336.184	69.32
	JMJD1C	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	Divided	Low confidence	305.472	247.246	1.2355
	MAP1LC3A	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]		High confidence	56.7252	75.3954	1.32913
17	ATG4B	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]			56.7841	75.447	1.32866
	BOK	bcl2-related ovarian killer. [refseq;acc:nm_032515]	Subtracted	Low confidence	265.638	223.235	42.403
	GNG5	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]		High confidence	266.864	336.182	69.318
	TMEM132A	gbp protein isoform a. [refseq;acc:nm_017870]	Divided	Low confidence	305.399	247.213	1.23537
18	GBE1	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]		High confidence	185.678	245.247	1.32082
	GNG10	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	Subtracted		266.865	336.181	69.316
	JMJD1A	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	Divided	Low confidence	305.303	247.169	1.2352
	PRKRAP1	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Subtracted		273.188	232.49	40.698
19	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		High confidence	266.865	336.178	69.313
	HINT1	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]		Low confidence	188.298	228.509	40.211
	PRSS3	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]	Divided		304.548	246.824	1.23387
	PYGB	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]		High confidence	185.678	245.247	1.32082
20	GNG11	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Subtracted		266.868	336.159	69.291
	PRSS1	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]	Divided	Low confidence	304.359	246.737	1.23354
	PYGL	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]		High confidence	185.678	245.247	1.32082
	TOB2	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Subtracted	Low confidence	297.273	258.59	38.683
21	MYO15A	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	Divided	High confidence	185.678	245.247	1.32082
	PIGF	phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]		Low confidence	198	163	1.21472
	TMEM132A	gbp protein isoform a. [refseq;acc:nm_017870]	Subtracted	High confidence	325.586	256.492	69.094
	TOB1	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]		Low confidence	296.837	258.33	38.507
22	MAP2K4	dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985]			210.241	246.125	35.884
	PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]		High confidence	322	253	69
	PYGM	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	Divided		185.678	245.247	1.32082
	TUSC3	n33 protein. [swissprot;acc:q13454]		Low confidence	198	163	1.21472
23	no value	implantation-associated protein. [refseq;acc:nm_032121]
	GNPDA2	glucosamine-6-phosphate isomerase. [refseq;acc:nm_138335]	Subtracted		247.202	282.937	35.735
	MFAP4	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]		High confidence	322	253	69
	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Divided		58	44	1.31818
24	GNPDA1	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	Subtracted	Low confidence	247.202	282.937	35.735
	HINT1	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]	Divided		188.298	228.509	1.21355
	PANK1	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]		High confidence	58	44	1.31818
	PPP1R14D	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	Subtracted		322	253	69
25	CYP27B1	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	Divided	Low confidence	286.396	238.476	1.20094
	FCN2	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	Subtracted	High confidence	322	253	69
	PANK2	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Divided		58	44	1.31818
	PIGF	phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]	Subtracted	Low confidence	198	163	35

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.