MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2280 to 2329 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
1140	hect type e3 ubiquitin ligase. [refseq;acc:nm_015052]	Subtracted	219.399	213.784	5.615
1141	ganglioside-induced differentiation-associated protein 1. [refseq;acc:nm_018972]	Divided	218.484	212.675	1.02731
	transducin-like enhancer protein 1 (esg1). [swissprot;acc:q04724]	Subtracted	219.375	213.767	5.608
1142	arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]		216.729	222.334	5.605
	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase 28 kda accessory protein). [swissprot;acc:q9y5k8]	Divided	218.484	212.675	1.02731
1143	kinesin protein. [refseq;acc:nm_032559]	Subtracted	224.858	219.264	5.594
	secretory pathway component sec31b-1. [refseq;acc:nm_015490]	Divided	218.484	212.675	1.02731
1144	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	Subtracted	135.844	130.259	5.585
	vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase 50/57 kda subunits) (vacuolar proton pump subunit sfd) (cgi-11). [swissprot;acc:q9ui12]	Divided	218.484	212.675	1.02731
1145	ny-ren-62 antigen (fragment). [sptrembl;acc:q9y590]	Subtracted	224.805	219.251	5.554
	vacuolar atp synthase subunit f (ec 3.6.3.14) (v-atpase f subunit) (vacuolar proton pump f subunit) (v-atpase 14 kda subunit). [swissprot;acc:q16864]	Divided	218.481	212.675	1.0273
1146	ubiquitin. [swissprot;acc:p02248]	Subtracted	209.061	203.518	5.543
	vacuolar atp synthase subunit b, kidney isoform (ec 3.6.3.14) (v- atpase b1 subunit) (vacuolar proton pump b isoform 1) (endomembrane proton pump 58 kda subunit). [swissprot;acc:p15313]	Divided	218.483	212.676	1.0273
1147	peroxisomal membrane protein pex14 (peroxin-14) (peroxisomal membrane anchor protein pex14) (pts1 receptor docking protein). [swissprot;acc:o75381]		208.651	203.109	1.02729
		Subtracted			5.542
1148	signal recognition particle receptor alpha subunit (sr-alpha) (docking protein alpha) (dp-alpha). [swissprot;acc:p08240]		224.878	219.342	5.536
	ubiquitin. [swissprot;acc:p02248]	Divided	209.061	203.518	1.02724
1149	bystin. [swissprot;acc:q13895]		239.505	233.185	1.0271
	kinesin-like protein kif2 (kinesin-2) (hk2). [swissprot;acc:o00139]	Subtracted	224.764	219.241	5.523
1150	sorting nexin 1. [swissprot;acc:q13596]	Divided	209.868	215.522	1.02694
	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]	Subtracted	218.186	212.672	5.514
1151	metaxin 1. [swissprot;acc:q13505]	Divided	199.552	204.925	1.02693
	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	Subtracted	218.186	212.672	5.514
1152	epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]	Divided	221.939	216.143	1.02682
	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]	Subtracted	218.186	212.672	5.514
1153	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]
	epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929]	Divided	221.93	216.146	1.02676
1154	cellular modulator of immune recognition. [refseq;acc:nm_145021]	Subtracted	218.186	212.672	5.514
	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181]	Divided	224.307	230.242	1.02646
1155	inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869]
	vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437]	Subtracted	218.186	212.672	5.514
1156	aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9]	Divided	224.307	230.242	1.02646
	gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326]	Subtracted	218.186	212.672	5.514
1157	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]	Divided	224.307	230.242	1.02646
	upstream binding protein 1 (lbp-1a). [refseq;acc:nm_014517]	Subtracted	220.742	215.237	5.505
1158	epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	Divided	221.877	216.167	1.02641
	transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]	Subtracted	220.742	215.237	5.505
1159	lbp-9. [refseq;acc:nm_014553]
	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	Divided	170.28	165.898	1.02641
1160	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]		208.55	214.041	1.02633
	splicing factor, arginine/serine-rich 3 (pre-mrna splicing factor srp20) (x16 protein). [swissprot;acc:p23152]	Subtracted	220.742	215.237	5.505
1161	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]		218.402	212.904	5.498
	kappa b-ras 1. [refseq;acc:nm_020345]	Divided	220.758	215.097	1.02632
1162	i-kappa-b-interacting ras-like protein 2. [refseq;acc:nm_017595]
	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase ac39 subunit) (v-atpase 40 kda accessory protein) (p39) (32 kda accessory protein). [swissprot;acc:p12953]	Subtracted	218.402	212.904	5.498
1163	adp-ribosylation factor-like protein 4. [swissprot;acc:p40617]
	snare associated protein snapin. [refseq;acc:nm_012437]	Divided	220.758	215.097	1.02632
1164	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	Subtracted	208.55	214.041	5.491
	transducin-like enhancer protein 4. [swissprot;acc:q04727]	Divided	219.438	213.818	1.02628
1165	caspase-7 precursor (ec 3.4.22.-) (ice-like apoptotic protease 3) (ice-lap3) (apoptotic protease mch-3) (cmh-1). [swissprot;acc:p55210]	Subtracted	233.942	228.46	5.482

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.