MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Hugo	Rank	Gene	Network Comparison Type	description	Value Type	network_comparison	Interaction Map	red	Filtered	green

Results: HTML CSV LaTeX

Showing element 501 to 550 of 6456 in total

Hugo  : no value
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Network Comparison Type	description	network_comparison	red	green
2412	Subtracted	mesoderm induction early response 1. [refseq;acc:nm_020948]	0.756	212.374	211.618
2415	Divided	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	1.00359	218.2	218.984
2425	Subtracted	pepsin a precursor (ec 3.4.23.1). [swissprot;acc:p00790]	0.724	235.812	235.088
2426	Divided	mesoderm induction early response 1. [refseq;acc:nm_020948]	1.00357	212.374	211.618
2428		alcohol dehydrogenase class iii chi chain (ec 1.1.1.1) (glutathione- dependent formaldehyde dehydrogenase) (ec 1.2.1.1) (fdh). [swissprot;acc:p11766]	1.00355	192.871	193.555
2439	Subtracted	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	0.701	194.407	193.706
2445		alcohol dehydrogenase class iii chi chain (ec 1.1.1.1) (glutathione- dependent formaldehyde dehydrogenase) (ec 1.2.1.1) (fdh). [swissprot;acc:p11766]	0.684	192.871	193.555
2448	Divided	glycine dehydrogenase [decarboxylating], mitochondrial precursor (ec 1.4.4.2) (glycine decarboxylase) (glycine cleavage system p- protein). [swissprot;acc:p23378]	1.00321	212.446	211.766
2453	Subtracted		0.68
2460	Divided	pepsin a precursor (ec 3.4.23.1). [swissprot;acc:p00790]	1.00308	235.812	235.088
2488		hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934]	1.00284	194.527	195.08
2489		dc11 protein. [refseq;acc:nm_020186]
2499	Subtracted	hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934]	0.553
2500		dc11 protein. [refseq;acc:nm_020186]
2521	Divided	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	1.00234	201.96	201.488
2524	Subtracted	proteasome subunit beta type 8 precursor (ec 3.4.25.1) (proteasome component c13) (macropain subunit c13) (multicatalytic endopeptidase complex subunit c13). [swissprot;acc:p28062]	0.474	212.464	211.99
2526		nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	0.472	201.96	201.488
2530	Divided	proteasome subunit beta type 8 precursor (ec 3.4.25.1) (proteasome component c13) (macropain subunit c13) (multicatalytic endopeptidase complex subunit c13). [swissprot;acc:p28062]	1.00224	212.464	211.99
2540	Subtracted	proteasome subunit beta type 9 precursor (ec 3.4.25.1) (proteasome chain 7) (macropain chain 7) (multicatalytic endopeptidase complex chain 7) (ring12 protein) (low molecular mass protein 2). [swissprot;acc:p28065]	0.406	213.494	213.088
2545	Divided		1.00191
2547		glycerol kinase, testis specific 2 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14410]	1.00186	206.894	206.51
	Subtracted	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]	0.389	222.658	223.047
2548	Divided	glycerol kinase, testis specific 1 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14409]	1.00185	206.899	206.516
	Subtracted	glycerol kinase, testis specific 2 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14410]	0.384	206.894	206.51
2549	Divided	glycerol kinase (ec 2.7.1.30) (atp:glycerol 3-phosphotransferase) (glycerokinase) (gk). [swissprot;acc:p32189]	1.00185	206.902	206.519
	Subtracted	glycerol kinase, testis specific 1 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14409]	0.383	206.899	206.516
2550		glycerol kinase (ec 2.7.1.30) (atp:glycerol 3-phosphotransferase) (glycerokinase) (gk). [swissprot;acc:p32189]		206.902	206.519
2559	Divided	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]	1.00175	222.658	223.047
2571		protein-tyrosine phosphatase, non-receptor type 1 (ec 3.1.3.48) (protein-tyrosine phosphatase 1b) (ptp-1b). [swissprot;acc:p18031]	1.00164	209.549	209.205
	Subtracted		0.344
2584	Divided	dystrophin. [swissprot;acc:p11532]	1.00154	213.422	213.75
	Subtracted		0.328
2599		dj470l14.3 (novel protein similar to the arp2/3 protein complex subunit p21-arc (arc21)). [sptrembl;acc:q9h5b6]	0.304	224.891	225.195
2608	Divided	nefa-interacting nuclear protein nip30. [refseq;acc:nm_024946]	1.0014	215.497	215.799
2613	Subtracted		0.302
2621	Divided	dj470l14.3 (novel protein similar to the arp2/3 protein complex subunit p21-arc (arc21)). [sptrembl;acc:q9h5b6]	1.00135	224.891	225.195
2637		small glutamine rich protein with tetratricopeptide repeats 2. [refseq;acc:nm_019072]	1.00126	187.075	186.84
2644	Subtracted	nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]	0.244	213.63	213.874
2646		small glutamine rich protein with tetratricopeptide repeats 2. [refseq;acc:nm_019072]	0.235	187.075	186.84
2649	Divided	nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]	1.00114	213.63	213.874
2678		ral guanine nucleotide dissociation stimulator-like 2 (ralgds-like factor) (ras-associated protein rab2l). [swissprot;acc:o15211]	1.00098	144.411	144.552
2682		transforming protein n-ras. [swissprot;acc:p01111]	1.00095	144.427	144.564
2684	Subtracted	peroxisomal 3,2-trans-enoyl-coa isomerase (ec 5.3.3.8) (dodecenoyl-coa delta-isomerase) (d3,d2-enoyl-coa isomerase) (dbi-related protein 1) (drs-1) (hepatocellular carcinoma-associated antigen 88). [swissprot;acc:o75521]	0.165	194.557	194.392
2688	Divided		1.00085
2696	Subtracted	ral guanine nucleotide dissociation stimulator-like 2 (ralgds-like factor) (ras-associated protein rab2l). [swissprot;acc:o15211]	0.141	144.411	144.552
2698		transforming protein n-ras. [swissprot;acc:p01111]	0.137	144.427	144.564
2700	Divided	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	1.00066	188.435	188.31
2701	Subtracted	importin 7; ran-binding protein 7. [refseq;acc:nm_006391]	0.126	220.521	220.395
2708		succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	0.125	188.435	188.31
2709	Divided	importin 7; ran-binding protein 7. [refseq;acc:nm_006391]	1.00057	220.521	220.395

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.