MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 708 to 757 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
354	STX10	syntaxin 10 (syn10). [swissprot;acc:o60499]	High confidence	234.691	257.442	1.09694
355	RPP30	ribonuclease p protein subunit p30 (ec 3.1.26.5) (rnasep protein p30) (rnase p subunit 2). [swissprot;acc:p78346]	Low confidence	202.542	210.311	1.03836
	STX6	syntaxin 6. [swissprot;acc:o43752]	High confidence	234.673	257.414	1.09691
356	no value	60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025]		243.24	266.796	1.09684
	SF3A3	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	Low confidence	202.387	194.949	1.03815
357	no value	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	High confidence	243.12	266.661	1.09683
	SF3A1	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	Low confidence	202.387	194.949	1.03815
358	MOCS2	molybdenum cofactor synthesis protein 2 large subunit (molybdopterin synthase large subunit) (mpt synthase large subunit) (mocs2b) (moco1- b). [swissprot;acc:o96007]		207.531	199.938	1.03798
	RPL10L	ribosomal protein l10-like protein. [refseq;acc:nm_080746]	High confidence	243.12	266.662	1.09683
359	MOCS3	molybdenum cofactor synthesis protein 3 (molybdopterin synthase sulfurylase) (mpt synthase sulfurylase). [swissprot;acc:o95396]	Low confidence	207.531	199.938	1.03798
	RPL4	60s ribosomal protein l4 (l1). [swissprot;acc:p36578]	High confidence	239.277	262.434	1.09678
360	no value	secreted modular calcium-binding protein 1. [refseq;acc:nm_022137]	Low confidence	204.231	196.773	1.0379
	SEC61G	protein transport protein sec61 gamma subunit. [swissprot;acc:p38384]	High confidence	243.072	266.559	1.09663
361	MRPL17	mitochondrial ribosomal protein l17; lyst-interacting protein lip2. [refseq;acc:nm_022061]		242.83	266.248	1.09644
	PFDN1	prefoldin subunit 1. [swissprot;acc:o60925]	Low confidence	204.231	196.773	1.0379
362	SHROOM2	apical-like protein (apxl protein). [swissprot;acc:q13796]	High confidence	231.492	211.136	1.09641
	SMOC2	secreted modular calcium-binding protein 2; smooth muscle associated protein 2. [refseq;acc:nm_022138]	Low confidence	204.231	196.773	1.0379
363	CHDH	choline dehydrogenase. [refseq;acc:nm_018397]
	SHROOM3	shroom-related protein; f-actin-binding protein; likely ortholog of mouse shroom. [refseq;acc:nm_020859]	High confidence	231.481	211.131	1.09639
364	DGCR14	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	Low confidence	212.235	204.495	1.03785
	POLR2B	dna-directed rna polymerase ii 140 kda polypeptide (ec 2.7.7.6) (rna polymerase ii subunit 2) (rpb2). [swissprot;acc:p30876]	High confidence	243.208	266.617	1.09625
365	MRPL36	60s ribosomal protein l36, mitochondrial precursor (l36mt) (brca1- interacting protein 1). [swissprot;acc:q9p0j6]		242.744	266.07	1.09609
	SPAG7	sperm associated antigen 7. [refseq;acc:nm_004890]	Low confidence	117.525	121.959	1.03773
366	RPS5	40s ribosomal protein s5. [swissprot;acc:p46782]	High confidence	242.473	265.756	1.09602
	ZMIZ1	retinoic acid induced 17; pias-like protein hzimp10. [refseq;acc:nm_020338]	Low confidence	207.433	199.944	1.03746
367	HNRPM	heterogeneous nuclear ribonucleoprotein m (hnrnp m). [swissprot;acc:p52272]	High confidence	234.146	256.627	1.09601
	SORBS1	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	Low confidence	206.945	199.503	1.0373
368	PUS1	trna pseudouridine synthase a (ec 4.2.1.70) (pseudouridylate synthase i) (pseudouridine synthase i) (uracil hydrolyase). [swissprot;acc:q9y606]	High confidence	242.66	265.715	1.09501
	SPSB4	spry domain-containing socs box protein ssb-4. [refseq;acc:nm_080862]	Low confidence	219.655	211.763	1.03727
369	MRPL12	60s ribosomal protein l12, mitochondrial precursor (l12mt) (5c5-2). [swissprot;acc:p52815]	High confidence	242.159	265.104	1.09475
	MXD1	mad protein (max dimerizer). [swissprot;acc:q05195]	Low confidence	205.943	198.554	1.03721
370	AFF1	af-4 protein (proto-oncogene af4) (fel protein). [swissprot;acc:p51825]		219.597	211.722	1.0372
	NUDT12	nudix (nucleoside diphosphate linked moiety x)-type motif 12. [refseq;acc:nm_031438]	High confidence	242.159	265.104	1.09475
371	AFF2	fragile x mental retardation 2 protein (protein fmr-2) (fmr2p) (ox19 protein) (fragile x e mental retardation syndrome protein). [swissprot;acc:p51816]	Low confidence	219.599	211.723	1.0372
	RPS6KC1	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	High confidence	186.52	170.42	1.09447
372	no value	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]
	AFF3	laf-4 protein (lymphoid nuclear protein related to af4). [swissprot;acc:p51826]	Low confidence	219.598	211.722	1.0372
373	AFF4	all1 fused gene from 5q31. [refseq;acc:nm_014423]
	MRPL11	60s ribosomal protein l11, mitochondrial precursor (l11mt) (cgi-113). [swissprot;acc:q9y3b7]	High confidence	242.37	265.255	1.09442
374	PGBD3	excision repair protein ercc-6 (cockayne syndrome protein csb). [swissprot;acc:q03468]	Low confidence	210.34	202.797	1.03719
	TFDP2	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	High confidence	267.208	244.168	1.09436
375	POLR3A	dna-directed rna polymerase iii largest subunit (ec 2.7.7.6) (rpc155) (rpc1). [swissprot;acc:o14802]		242.686	265.516	1.09407
	SPSB1	spry domain-containing socs box protein ssb-1. [refseq;acc:nm_025106]	Low confidence	219.556	211.692	1.03715
376	CCRN4L	nocturnin (ccr4 protein homolog). [swissprot;acc:q9uk39]		209.328	201.83
	DDX56	probable atp-dependent 61 kda nucleolar rna helicase (dead-box protein 21). [swissprot;acc:q9ny93]	High confidence	257.017	234.945	1.09395
377	LDHAL6B	l-lactate dehydrogenase a-like (ec 1.1.1.27). [swissprot;acc:q9byz2]	Low confidence	205.928	198.554	1.03714
	POLR1A	dna-directed rna polymerase i largest subunit (ec 2.7.7.6) (rna polymerase i 194 kda subunit) (rpa194). [swissprot;acc:o95602]	High confidence	242.691	265.481	1.09391
378	LDHC	l-lactate dehydrogenase c chain (ec 1.1.1.27) (ldh-c) (ldh testis subunit) (ldh-x). [swissprot;acc:p07864]	Low confidence	205.928	198.554	1.03714
	RPL30	60s ribosomal protein l30. [swissprot;acc:p04645]	High confidence	242.593	265.365	1.09387
379	AK2	adenylate kinase isoenzyme 2, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p54819]		241.509	264.163	1.0938

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.