MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

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Showing element 2080 to 2129 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	green	red	network_comparison
2080	PIK3C2B	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]	214.28	215.967	1.00787
2081	DNM1L	dynamin 1-like protein isoform 3; dynamin-like protein. [refseq;acc:nm_005690]
2082	PIK3C2A	phosphoinositide-3-kinase, class 2, alpha polypeptide; c2-containing phosphatidylinositol kinase. [refseq;acc:nm_002645]
2083	PTPRA	vacuolar protein sorting 16 (hvps16). [swissprot;acc:q9h269]	213.579	215.258	1.00786
2084	no value	glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (ec 2.6.1.16) (hexosephosphate aminotransferase 1) (d-fructose-6- phosphate amidotransferase 1) (gfat 1) (gfat1). [swissprot;acc:q06210]	224.293	222.548	1.00784
2085	IDH3A	isocitrate dehydrogenase [nad] subunit alpha, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:p50213]	224.32	222.58	1.00782
2086	IDH3B	isocitrate dehydrogenase [nad] subunit beta, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:o43837]
2087	IDH3G	isocitrate dehydrogenase [nad] subunit gamma, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:p51553]
2088	MPP3	maguk p55 subfamily member 3 (mpp3 protein) (discs, large homolog 3). [swissprot;acc:q13368]	216.433	218.124	1.00781
2089	UTP14A	serologically defined colon cancer antigen 16. [refseq;acc:nm_006649]	213.479	215.144	1.0078
2090	GFPT2	glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (ec 2.6.1.16) (hexosephosphate aminotransferase 2) (d-fructose-6- phosphate amidotransferase 2) (gfat 2) (gfat2). [swissprot;acc:o94808]	224.344	222.609	1.00779
2091	SNUPN	rna, u transporter 1; snurportin-1. [refseq;acc:nm_005701]	210.052	211.679	1.00775
2092	ECSIT	evolutionarily conserved signaling intermediate in toll pathway; ecsit. [refseq;acc:nm_016581]	210.369	211.992	1.00772
2093	RBKS	ribokinase (ec 2.7.1.15). [swissprot;acc:q9h477]	208.387	209.994	1.00771
2094	PMS2	pms1 protein homolog 2 (dna mismatch repair protein pms2). [swissprot;acc:p54278]	205.747	207.321	1.00765
2095	POLS	polymerase (dna directed) sigma; topoisomerase-related function protein 4-1; polymerase (dna-directed) sigma. [refseq;acc:nm_006999]	227.53	229.266	1.00763
2096	CCDC92	limkain beta 2. [refseq;acc:nm_025140]	216.089	217.723	1.00756
2097	CCDC85B	delta-interacting protein a (hepatitis delta antigen interacting protein a). [swissprot;acc:q15834]	213.39	214.979	1.00745
2098	no value	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	178.831	177.515	1.00741
2099	SUMO3	ubiquitin-like protein smt3a. [swissprot;acc:p55854]	213.27	211.71	1.00737
2100	no value	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]
2101	ACRC	acrc protein; putative nuclear protein. [refseq;acc:nm_052957]
2102	EIF5AP1	eukaryotic translation initiation factor 5a (eif-5a) (eif-4d) (rev- binding factor). [swissprot;acc:p10159]	210.263	208.727	1.00736
2103	TKT	transketolase (ec 2.2.1.1) (tk). [swissprot;acc:p29401]	216.236	214.666	1.00731
2104	DTYMK	thymidylate kinase (ec 2.7.4.9) (dtmp kinase). [swissprot;acc:p23919]	207.813	209.328	1.00729
2105	EIF5A2	eif-5a2 protein. [refseq;acc:nm_020390]	210.111	208.591
2106	ISL1	insulin gene enhancer protein isl-1 (islet-1). [swissprot;acc:p20663]	196.061	197.489	1.00728
2107	LMO7	lim domain only 7; zinc-finger domain-containing protein; lomp protein; f-box only protein 20; f-box protein fbx20. [refseq;acc:nm_005358]	217.801	216.23	1.00727
2108	ASL	argininosuccinate lyase (ec 4.3.2.1) (arginosuccinase) (asal). [swissprot;acc:p04424]	217.93	216.36	1.00726
2109	RANBP2	ran-binding protein 2 (ranbp2) (nuclear pore complex protein nup358) (nucleoporin nup358) (358 kda nucleoporin) (p270). [swissprot;acc:p49792]	217.47	219.032	1.00718
2110	COG6	conserved oligomeric golgi complex component 6. [swissprot;acc:q9y2v7]	209.607	211.099	1.00712
2111	no value	ran-binding protein 2-like 1 isoform 2; sperm membrane protein bs-63; ran-binding protein 2-like 1. [refseq;acc:nm_032260]	217.511	219.047	1.00706
2112	POLR3K	dna-directed rna polymerases iii 12.5 kda polypeptide (ec 2.7.7.6) (rna polymerase iii c11 subunit) (hsc11p) (hrpc11) (my010 protein). [swissprot;acc:q9y2y1]	224.989	223.415	1.00705
2113	no value	ran-binding protein 2-like 1 isoform 2; sperm membrane protein bs-63; ran-binding protein 2-like 1. [refseq;acc:nm_032260]	217.533	219.055	1.007
2114	LIPF	triacylglycerol lipase, gastric precursor (ec 3.1.1.3) (gastric lipase) (gl). [swissprot;acc:p07098]	213.14	214.632
2115	LIPM	ba304i5.1 (novel lipase) (fragment). [sptrembl;acc:q96lg2]
2116	LIPA	lysosomal acid lipase/cholesteryl ester hydrolase precursor (ec 3.1.1.13) (lal) (acid cholesteryl ester hydrolase) (sterol esterase) (lipase a) (cholesteryl esterase). [swissprot;acc:p38571]
2117	SARS2	seryl-trna synthetase, mitochondrial precursor (ec 6.1.1.11) (serine--trna ligase) (serrsmt). [swissprot;acc:q9np81]
2118	SARS	seryl-trna synthetase (ec 6.1.1.11) (serine--trna ligase) (serrs). [swissprot;acc:p49591]
2119	KCMF1	potassium channel modulatory factor 1; potassium channel modulatory factor; differentially expressed in branching tubulogenesis 91; zinc finger, zz domain containing 1. [refseq;acc:nm_020122]	222.788	221.248	1.00696
2120	SLC23A1	solute carrier family 23, member 1 (sodium-dependent vitamin c transporter 1) (hsvct1) (na(+)/l-ascorbic acid transporter 1) (yolk sac permease-like molecule 3). [swissprot;acc:q9uhi7]
2121	HNRPA3	heterogeneous nuclear ribonucleoprotein a3 (hnrnp a3) (d10s102). [swissprot;acc:p51991]
2122	LGALS9	galectin-9 (hom-hd-21) (ecalectin). [swissprot;acc:o00182]	207.911	206.473
2123	ARF4	adp-ribosylation factor 4. [swissprot;acc:p18085]	222.788	221.248
2124	AKTIP	fused toes homolog; likely ortholog of mouse fused toes. [refseq;acc:nm_022476]
2125	SHC1	shc transforming protein. [swissprot;acc:p29353]
2126	ZNF289	zinc finger protein 289, id1 regulated; likely ortholog of mouse zfp289. [refseq;acc:nm_032389]
2127	SHC3	neuronal shc. [refseq;acc:nm_016848]
2128	ARF1	adp-ribosylation factor 1. [swissprot;acc:p32889]
2129	HNRNPA1	heterogeneous nuclear ribonucleoprotein a1 (helix-destabilizing protein) (single-strand binding protein) (hnrnp core protein a1). [swissprot;acc:p09651]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.