MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 594 to 643 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	red	network_comparison	green
594	pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]	CDC40	223.282	1.06256	210.136
595	vav proto-oncogene. [swissprot;acc:p15498]	VAV1	212.2	1.0618	199.849
596	vav-3 protein. [swissprot;acc:q9ukw4]	VAV3	212.253	1.06175	199.908
597	vav-2 protein. [swissprot;acc:p52735]	VAV2	212.526	1.0615	200.212
598	rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]	AKT1	248.463	1.06138	234.095
599	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	AKT3
600	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]	AKT2
601	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	VPS39	206.274	1.06069	218.792
602	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	MAP4
603	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	LEF1	225.829	1.0605	212.945
604	60s ribosomal protein l15. [swissprot;acc:p39030]	RPL15	217.862	1.0602	230.978
605	histone h2b.c (h2b/c). [swissprot;acc:q99880]	HIST1H2BL	247.47	1.0601	233.441
606	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	HIST2H2BA
607	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	no value
608	histone h2b. [refseq;acc:nm_175055]
609	histone h2b.s (h2b/s). [swissprot;acc:p57053]
610	histone h2b.d (h2b/d). [swissprot;acc:q99877]
611	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	HIST3H3
612	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]	HIST1H2BA
613	histone h2b.e (h2b/e). [swissprot;acc:q99879]	no value
614	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	HOXA10	214.257	1.06002	202.125
615	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]	HOXB9		1.05999	202.132
616	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]	HOXA9
617	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	HOXC9		1.05997	202.135
618	gamma-aminobutyric-acid receptor gamma-3 subunit precursor (gaba(a) receptor). [swissprot;acc:q99928]	GABRG3	214.256	1.05994	202.139
619	forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]	FOXG1
620	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]	GABRG1			202.14
621	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	GABRA2
622	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]	GABRA6
623	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	GABRG2
624	interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]	no value			202.139
625	gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]	GABRA4			202.14
626	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]	GABRE
627	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	JMJD6			202.139
628	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	GABRA1			202.14
629	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	GABRA3
630	nadh-ubiquinone oxidoreductase b14 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b14) (ci-b14). [swissprot;acc:p56556]	NDUFA6		1.05993	202.141
631	similar to expressed sequence aa415817. [sptrembl;acc:q8n4q9]	PDXDC1
632	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	HOXD9	214.254	1.05979	202.166
633	alanyl-trna synthetase (ec 6.1.1.7) (alanine--trna ligase) (alars). [swissprot;acc:p49588]	AARS	234.106		248.104
634	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	no value	226.523	1.05958	213.786
635	60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]	RPL37	228.639	1.05957	242.258
636	splicing factor, arginine/serine-rich 1 (pre-mrna splicing factor sf2, p33 subunit) (alternative splicing factor asf-1). [swissprot;acc:q07955]	SFRS1
637	amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]	PPAT
638	sorting nexin 17. [swissprot;acc:q15036]	SNX17
639	nucleoporin-like protein rip (hiv-1 rev-binding protein) (rev interacting protein) (rev/rex activation domain-binding protein). [swissprot;acc:p52594]	HRB	217.67	1.05938	230.596
640	intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811]	no value
641	pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152]	PRAM1
642	intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3]	no value
643	hiv-1 rev binding protein-like; rev/rex activation domain binding protein-related. [refseq;acc:nm_006076]	HRBL

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.