MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1080 to 1129 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
540	SEPHS2	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	Low confidence	206.406	200.027	1.03189
541	MICAL2	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	High confidence	222.156	208.201	1.06703
			Low confidence	206.406	200.027	1.03189
542	INPP4B	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]	High confidence	222.156	208.201	1.06703
			Low confidence	206.406	200.027	1.03189
543	SEPHS1	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	High confidence	222.156	208.201	1.06703
			Low confidence	206.406	200.027	1.03189
544	INPP4A	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]	High confidence	222.156	208.201	1.06703
			Low confidence	206.406	200.027	1.03189
545	EIF6	eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]	High confidence	248.866	233.287	1.06678
	RPUSD2	c18b11 homolog (44.9kd). [refseq;acc:nm_152260]	Low confidence	202.949	196.678	1.03188
546	TMBIM4	z-protein (protein cgi-119) (s1r protein). [swissprot;acc:q9hc24]
	WAS	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	High confidence	207.222	194.262	1.06671
547	CRK	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]		207.26	194.346	1.06645
	SESN3	sestrin 3. [swissprot;acc:p58005]	Low confidence	203.305	197.023	1.03188
548	ABL2	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]	High confidence	207.26	194.346	1.06645
	FLOT1	flotillin-1. [swissprot;acc:o75955]	Low confidence	203.303	197.022	1.03188
549	no value	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	High confidence	207.26	194.346	1.06645
	SESN2	sestrin 2 (hi95). [swissprot;acc:p58004]	Low confidence	203.306	197.024	1.03188
550	HCK	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	High confidence	207.26	194.346	1.06645
	SESN1	sestrin 1 (p53-regulated protein pa26). [swissprot;acc:q9y6p5]	Low confidence	203.299	197.018	1.03188
551	AP1M2	adaptor-related protein complex 1, mu 2 subunit (mu-adaptin 2) (adaptor protein complex ap-1 mu-2 subunit) (golgi adaptor ha1/ap1 adaptin mu-2 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 2) (ap-mu chain family member mu1b). [swissprot;acc:q9y6q5]		205.768	199.453	1.03166
	GRAP2	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	High confidence	207.261	194.347	1.06645
552	CRKL	crk-like protein. [swissprot;acc:p46109]		207.26	194.346
	GRAP	grb2-related adaptor protein. [swissprot;acc:q13588]	Low confidence	203.511	197.267	1.03165
553	ABL1	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	High confidence	207.26	194.346	1.06645
	AP1M1	adaptor-related protein complex 1, mu 1 subunit (mu-adaptin 1) (adaptor protein complex ap-1 mu-1 subunit) (golgi adaptor ha1/ap1 adaptin mu-1 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 1) (clathrin coat assembly protein ap47) (clathrin coat associated protein ap47) (ap-mu chain family member mu1a). [swissprot;acc:q9bxs5]	Low confidence	205.75	199.452	1.03158
554	FYN	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	High confidence	207.26	194.346	1.06645
	NUTF2	nuclear transport factor 2 (ntf-2) (placental protein 15) (pp15). [swissprot;acc:p13662]	Low confidence	205.57	199.279	1.03157
555	CDC40	pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]		201.554	195.387	1.03156
	FGR	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	High confidence	207.26	194.346	1.06645
556	CUTL1	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]		207.27	194.368	1.06638
	MOBKL3	preimplantation protein 3; likely ortholog of preimplantation protein 3. [refseq;acc:nm_015387]	Low confidence	206.737	200.417	1.03153
557	CUTL2	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	High confidence	207.272	194.371	1.06637
	DNAJB11	dnaj homolog subfamily b member 11 precursor (er-associated dnaj protein 3) (erj3) (er-associated hsp40 co-chaperone) (hdj9) (pwp1- interacting protein 4). [swissprot;acc:q9ubs4]	Low confidence	206.737	200.417	1.03153
558	no value	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	High confidence	135.087	144.041	1.06628
	HTATSF1	hiv tat specific factor 1; cofactor required for tat activation of hiv-1 transcription. [refseq;acc:nm_014500]	Low confidence	209.347	202.978	1.03138
559	SSRP1	structure-specific recognition protein 1 (ssrp1) (recombination signal sequence recognition protein) (t160) (chromatin-specific transcription elongation factor 80 kda subunit) (fact 80 kda subunit). [swissprot;acc:q08945]		205.184	198.948	1.03134
	WASL	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	High confidence	207.309	194.452	1.06612
560	GYG2	glycogenin-2 (ec 2.4.1.186) (gn-2) (gn2). [swissprot;acc:o15488]	Low confidence	199.227	193.173	1.03134
	SOS1	son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	High confidence	205.74	193.021	1.06589
561	ATP9A	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	Low confidence	202.845	209.189	1.03128
	SOS2	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]	High confidence	205.89	193.183	1.06578
562	ECHS1	enoyl-coa hydratase, mitochondrial precursor (ec 4.2.1.17) (short chain enoyl-coa hydratase) (sceh) (enoyl-coa hydratase 1). [swissprot;acc:p30084]	Low confidence	203.367	197.208	1.03123
	GULP1	ptb domain adaptor protein ced-6; engulfment adapter protein. [refseq;acc:nm_016315]	High confidence	220.744	207.121	1.06577
563	CAPS	calcyphosine. [swissprot;acc:q13938]
	CYP4F8	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]	Low confidence	203.155	197.018	1.03115
564	COX15	cox15 homolog isoform 2 precursor; cytochrome c oxidase subunit 15; cytochrome c oxidase assembly protein. [refseq;acc:nm_004376]		203.197	197.076	1.03106
	CRNKL1	crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]	High confidence	220.744	207.121	1.06577
565	CYP4F12	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	Low confidence	203.157	197.064	1.03092

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.