MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	Network Comparison Type	description	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 7460 in total

Value Type  : Ranked
Interaction Map  : High confidence

Rank	Hugo	Network Comparison Type	description	Filtered	green	red	network_comparison
1	no value	Subtracted	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0	21883	8906	12977
	ARFGAP3	Divided	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]		15915	4294	3.70633
	HLX	Subtracted	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	1	322	215	107
	UBAC1	Divided	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		24	10	2.4
2	no value		mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		28	15	1.86667
	ARFGAP3	Subtracted	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	0	15915	4294	11621
	HBS1L		hbs1-like. [refseq;acc:nm_006620]	1	322	215	107
	STARD3	Divided	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	0	14977	5865	2.55362
3	no value		nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]		11083.9	4475.84	2.47638
	PERLD1	Subtracted	cab2. [refseq;acc:nm_033419]		10950	21866	10916
	PSCD1	Divided	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	1	28	15	1.86667
	RINT1	Subtracted	rad50-interacting protein 1. [refseq;acc:nm_021930]		232	337	105
4	no value	Divided	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0	21883	8906	2.45711
		Subtracted	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]		21888	11525	10363
	PSCD2	Divided	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	1	28	15	1.86667
	RHOBTB2	Subtracted	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]		232	337	105
5	no value	Divided	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	0	11965.7	5510.5	2.17144
	PSCD4		cytohesin 4. [swissprot;acc:q9uia0]	1	28	15	1.86667
	TBL1Y	Subtracted	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	0	21888	11525	10363
	XAB1		xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	1	309	212	97
6	ATPBD1C		protein x 0004. [refseq;acc:nm_016301]
	PSCD3	Divided	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]		28	15	1.86667
	STARD3	Subtracted	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	0	14977	5865	9112
	UBE3B	Divided	ubiquitin protein ligase. [refseq;acc:nm_130466]		15339.2	7523	2.03897
7	no value	Subtracted	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		13216	22286	9070
	HLX	Divided	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	1	322	215	1.49767
	PERLD1		cab2. [refseq;acc:nm_033419]	0	10950	21866	1.99689
	UFC1	Subtracted	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	1	212.554	288.754	76.2
8	no value	Divided	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	0	21888	11525	1.89918
		Subtracted	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]		13216	22286	9070
	HBS1L	Divided	hbs1-like. [refseq;acc:nm_006620]	1	322	215	1.49767
	JPH3	Subtracted	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]		362	288	74
9	no value		homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	0	13216	22286	9070
	JPH2		junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	1	362	288	74
	TBL1Y	Divided	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	0	21888	11525	1.89918
	XAB1		xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	1	309	212	1.45755
10	ATPBD1C		protein x 0004. [refseq;acc:nm_016301]
	FBP2		fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	0	14178.1	7509.39	1.88805
	PNPO	Subtracted	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]		12479	20989	8510
	SMPD2		sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	1	362	288	74
11	ATP9A	Divided	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	0	6248	11627	1.86092
	CCNH	Subtracted	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]		20670.6	12170.7	8499.9
	RINT1	Divided	rad50-interacting protein 1. [refseq;acc:nm_021930]	1	232	337	1.45259
	TMEM33	Subtracted	db83 protein. [swissprot;acc:p57088]		362	288	74
12	no value		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]		336.233	266.856	69.377
			succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	0	11267	19403	8136
	FPGS	Divided	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]		5208.84	9429.18	1.81023
	RHOBTB2		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	1	232	337	1.45259
13	no value		heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107]	0	9264.5	5210.5	1.77804
		Subtracted	dystrophin. [swissprot;acc:p11532]		18054.8	10232.5	7822.3

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.