MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 2362 to 2411 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
ephrin type-a receptor 5 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor ehk-1) (eph homology kinase-1) (receptor protein- tyrosine kinase hek7). [swissprot;acc:p54756]	1093	EPHA5	Low confidence	210.722	205.826	1.02379
ephrin type-a receptor 7 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor ehk-3) (eph homology kinase-3) (receptor protein- tyrosine kinase hek11). [swissprot;acc:q15375]	1096	EPHA7
ephrin type-a receptor 8 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor eek) (eph-and elk-related kinase) (hek3). [swissprot;acc:p29322]	1102	EPHA8
ephrin type-b receptor 1 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor eph-2) (net) (hek6) (elk). [swissprot;acc:p54762]	1092	EPHB1
ephrin type-b receptor 2 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor eph-3) (drt) (receptor protein-tyrosine kinase hek5) (erk). [swissprot;acc:p29323]	1097	EPHB2
ephrin type-b receptor 4 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor htk). [swissprot;acc:p54760]	1100	no value
ephrin type-b receptor 6 precursor (tyrosine-protein kinase-defective receptor eph-6) (hep). [swissprot;acc:o15197]	1101	EPHB6
epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929]	740	EPS8		206.469	201.011	1.02715
	1153		High confidence	221.93	216.146	1.02676
epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]	738	EPS8L1	Low confidence	206.474	201.013	1.02717
	1152		High confidence	221.939	216.143	1.02682
epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	755	EPS8L2	Low confidence	206.435	201.001	1.02703
	1158		High confidence	221.877	216.167	1.02641
epidermal growth factor receptor precursor (ec 2.7.1.112) (receptor protein-tyrosine kinase erbb-1). [swissprot;acc:p00533]	757	EGFR	Low confidence	211.344	205.788	1.027
	2005		High confidence	225.019	222.971	1.00919
epidermal growth factor receptor substrate 15 (protein eps15) (af-1p protein). [swissprot;acc:p42566]	2312	EPS15	Low confidence	198.006	194.375	1.01868
epidermal growth factor receptor substrate eps15r. [refseq;acc:nm_021235]	2299	EPS15L1		198.098	194.455	1.01873
epididymal secretory protein e1 precursor (niemann-pick disease type c2 protein) (epi-1) (he1) (epididymal secretory protein 14.6) (esp14.6). [swissprot;acc:q15668]	1339	NPC2	High confidence	205.204	200.71	1.02239
	1708		Low confidence	200.171	196.144	1.02053
epithelial discoidin domain receptor 1 precursor (ec 2.7.1.112) (tyrosine-protein kinase cak) (cell adhesion kinase) (tyrosine kinase ddr) (discoidin receptor tyrosine kinase) (trk e) (protein-tyrosine kinase rtk 6) (cd167a antigen). [swissprot;acc:q08345]	2723	DDR1		200.785	197.332	1.0175
epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	320	CDH1	High confidence	241.892	265.96	1.0995
	4163		Low confidence	207.356	209.52	1.01044
epoxide hydrolase 1 (ec 3.3.2.3) (microsomal epoxide hydrolase) (epoxide hydratase). [swissprot;acc:p07099]	2446	EPHX1	High confidence	182.272	181.683	1.00324
	3256		Low confidence	200.756	197.638	1.01578
epsin 1; eh domain-binding mitotic phosphoprotein. [refseq;acc:nm_013333]	1576	EPN1		191.484	187.529	1.02109
	2430		High confidence	217.873	218.644	1.00354
epsin 2 isoform b; eps15 binding protein. [refseq;acc:nm_014964]	1504	EPN2	Low confidence	192.267	188.242	1.02138
	2550		High confidence	217.587	217.988	1.00184
epsin 3. [refseq;acc:nm_017957]	1627	EPN3	Low confidence	190.847	186.958	1.0208
	2297		High confidence	218.153	219.284	1.00518
er lumen protein retaining receptor 1 (kdel receptor 1). [swissprot;acc:p24390]	1079	KDELR1	Low confidence	202.92	198.191	1.02386
er lumen protein retaining receptor 2 (kdel receptor 2) (elp-1). [swissprot;acc:p33947]	1078	KDELR2
er-resident protein erdj5; macrothioredoxin; j-domain-containing protein disulfide isomerase-like protein. [refseq;acc:nm_018981]	2053	DNAJC10		202.377	198.538	1.01934
erbb2 interacting protein; densin-180-like protein; erbb2-interacting protein. [refseq;acc:nm_018695]	3083	ERBB2IP		200.306	197.048	1.01653
ergic-53 protein precursor (er-golgi intermediate compartment 53 kda protein) (lectin, mannose-binding 1) (gp58) (intracellular mannose specific lectin mr60). [swissprot;acc:p49257]	911	LMAN1		203.401	198.407	1.02517
	3177		High confidence	0.00001	0.00001	1
ero1-like. [refseq;acc:nm_014584]	911	no value		217.168	209.207	1.03805
	3842		Low confidence	203.763	201.128	1.0131
erythroid differentiation and denucleation factor 1. [swissprot;acc:o60584]	1566	SLMO1	High confidence	221.128	224.767	1.01646
	4844		Low confidence	203.909	203.244	1.00327
erythroid differentiation-related factor 1. [refseq;acc:nm_015608]	3095	C10orf137	High confidence	0.00001	0.00001	1
	3370		Low confidence	200.658	197.607	1.01544
erythropoietin 4 immediate early response; uncharacterized hypothalamus protein ht010. [refseq;acc:nm_018471]	2583	ZC3H15		202.361	198.784	1.01799
espin. [refseq;acc:nm_031475]	1257	ESPNP	High confidence	219.354	224.7	1.02437
	2885		Low confidence	203.506	200.086	1.01709
est1p-like protein a. [refseq;acc:nm_017575]	2013	SMG6		202.786	198.919	1.01944
esterase d (ec 3.1.1.1). [swissprot;acc:p10768]	1345	ESD		200.431	196.093	1.02212
	2429		High confidence	192.871	193.555	1.00355
estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061]	1050	HSD17B1		211.449	217.998	1.03097
	1802		Low confidence	199.594	195.657	1.02012

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.