MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 2813 to 2862 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
geranylgeranyl transferase type ii beta subunit (ec 2.5.1.-) (rab geranylgeranyltransferase beta subunit) (rab geranyl- geranyltransferase beta subunit) (rab gg transferase beta) (rab ggtase beta). [swissprot;acc:p53611]	1784	RABGGTB	Low confidence	203.098	199.079	1.02019
	2963		High confidence	0.00001	0.00001	1
germ cell specific y-box binding protein; contrin. [refseq;acc:nm_015982]	1061	YBX2	Low confidence	204.104	199.324	1.02398
	2685		High confidence	208.438	208.635	1.00095
germ cell-less. [refseq;acc:nm_022471]	1780	no value		206.335	203.877	1.01206
	4852		Low confidence	208.276	208.904	1.00302
gk001 protein. [refseq;acc:nm_020198]	2704	CCDC47	High confidence	188.435	188.311	1.00066
	3884		Low confidence	199.26	196.752	1.01275
gl004 protein. [refseq;acc:nm_020194]	3992	C2orf33		200.847	198.494	1.01185
gle1-like, rna export mediator; gle1 (yeast homolog)-like, rna export mediator; hgle1. [refseq;acc:nm_001499]	3054	GLE1L		198.893	195.647	1.01659
glia maturation factor gamma (gmf-gamma). [swissprot;acc:o60234]	1373	GMFG	High confidence	216.542	211.908	1.02187
	4543		Low confidence	210.648	208.971	1.00803
glioma amplified on chromosome 1 protein precursor. [swissprot;acc:o75325]	4711	LRRN2		206.04	204.881	1.00566
glioma pathogenesis-related protein (glipr) (rtvp-1 protein). [swissprot;acc:p48060]	1789	GLIPR1		203.094	199.083	1.02015
	2953		High confidence	0.00001	0.00001	1
glioma tumor suppressor candidate region gene 2 protein (p60). [swissprot;acc:q9nzm5]	321	SNORD23	Low confidence	207.402	199.219	1.04108
	3104		High confidence	0.00001	0.00001	1
glioma-amplified sequence-41; numa binding protein 1. [refseq;acc:nm_006530]	679	YEATS4	Low confidence	198.424	192.974	1.02824
	3007		High confidence	0.00001	0.00001	1
glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (ec 2.6.1.16) (hexosephosphate aminotransferase 1) (d-fructose-6- phosphate amidotransferase 1) (gfat 1) (gfat1). [swissprot;acc:q06210]	1546	no value	Low confidence	201.261	197.087	1.02118
	2084		High confidence	222.548	224.293	1.00784
glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (ec 2.6.1.16) (hexosephosphate aminotransferase 2) (d-fructose-6- phosphate amidotransferase 2) (gfat 2) (gfat2). [swissprot;acc:o94808]	1540	GFPT2	Low confidence	201.26	197.072	1.02125
	2090		High confidence	222.609	224.344	1.00779
glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	39	GNPDA1	Low confidence	247.202	282.937	1.14456
	3058		High confidence	0.00001	0.00001	1
glucosamine-6-phosphate isomerase. [refseq;acc:nm_138335]	38	GNPDA2	Low confidence	247.202	282.937	1.14456
	2861		High confidence	0.00001	0.00001	1
glucose transporter 14. [refseq;acc:nm_153449]	532	SLC2A14	Low confidence	205.541	199.115	1.03227
glucose-6-phosphate 1-dehydrogenase (ec 1.1.1.49) (g6pd). [swissprot;acc:p11413]	1701	G6PD	High confidence	216.079	219.024	1.01363
	1781		Low confidence	201.361	197.375	1.0202
glucose-6-phosphate isomerase (ec 5.3.1.9) (gpi) (phosphoglucose isomerase) (pgi) (phosphohexose isomerase) (phi) (neuroleukin) (nlk) (sperm antigen-36) (sa-36). [swissprot;acc:p06744]	1491	GPI	High confidence	217.704	221.839	1.01899
	3937		Low confidence	202.248	199.76	1.01245
glutamate carboxypeptidase-like protein 2 precursor. [swissprot;acc:q96kn2]	1682	CNDP1		199.393	195.367	1.02061
	2365		High confidence	208.958	209.82	1.00413
glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	165	GAD2		209.299	249.187	1.19058
	4259		Low confidence	201.502	199.6	1.00953
glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	167	GAD1	High confidence	209.299	249.187	1.19058
	4260		Low confidence	201.502	199.6	1.00953
glutamate dehydrogenase 1, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p00367]	1444	GLUDP5	High confidence	203.908	207.998	1.02006
	2114		Low confidence	200.568	196.785	1.01922
glutamate dehydrogenase 2, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p49448]	1443	GLUD2	High confidence	203.908	207.998	1.02006
	2112		Low confidence	200.568	196.785	1.01922
glutamate--cysteine ligase catalytic subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs heavy chain). [swissprot;acc:p48506]	1229	GCLC	High confidence	213.079	218.325	1.02462
	2513		Low confidence	202.157	198.552	1.01816
glutamate--cysteine ligase regulatory subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs light chain) (glutamate--cysteine ligase modifier subunit). [swissprot;acc:p48507]	1228	GCLM	High confidence	213.079	218.325	1.02462
	2512		Low confidence	202.157	198.552	1.01816
glutamate-rich wd-repeat protein. [swissprot;acc:q9bq67]	1848	GRWD1		203.397	199.424	1.01992
glutamine synthetase (ec 6.3.1.2) (glutamate--ammonia ligase). [swissprot;acc:p15104]	926	GLUL		201.442	196.519	1.02505
	2674		High confidence	203.151	202.948	1.001
glutaminyl-trna synthase (glutamine-hydrolyzing)-like 1. [refseq;acc:nm_018292]	1217	QRSL1		211.959	217.258	1.025

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.