MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	Value Type	description	Interaction Map	Filtered	red	green	network_comparison

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Showing element 601 to 650 of 66312 in total

Filtered  : 1

Rank	Hugo	Network Comparison Type	Value Type	description	Interaction Map	red	green	network_comparison
38	MAGEA10	Subtracted	Measured	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	High confidence	23693.7	18263	5430.7
	MAGEA2B		Squared	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Low confidence	82347.8	61881.5	20466.3
	MAGEB6B	Divided		melanoma antigen, family b, 6. [refseq;acc:nm_173523]				1.33073
	MFAP4		Ranked	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	High confidence	322	253	1.27273
	PANK3		Squared	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]		106226	192141	1.80879
	PPP1R14D	Subtracted	Rooted	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]		26.0288	43.1914	17.1626
	RAB11FIP4	Divided	Measured	rab11-family interacting protein 4. [refseq;acc:nm_032932]	Low confidence	7407.56	8696.7	1.17403
	WDR33	Subtracted	Squared	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	High confidence	226186	145568	80618
39	no value	Divided		melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Low confidence	82347.8	61881.5	1.33073
		Subtracted		hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]				20466.3
	CPSF1			cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	High confidence	226186	145568	80618
	FCN2		Rooted	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]		26.0288	43.1914	17.1626
	FOSL2			fos-related antigen 2. [swissprot;acc:p15408]	Low confidence	66.6469	75.3812	8.7343
	GNAI2	Divided	Measured	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	High confidence	1836.8	907.903	2.02312
			Rooted			40.28	24.37	1.65285
	GNB3	Subtracted	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]		268.565	334.483	65.918
	GNPDA1	Divided		glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	Low confidence	247.202	282.937	1.14456
	MAGEB4	Subtracted	Measured	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	High confidence	23693.7	18263	5430.7
	MAP2K4	Divided	Rooted	dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985]	Low confidence	63.4164	55.8176	1.13614
	NFU1	Subtracted	Measured	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]		12176.9	13781.8	1604.9
	PPP1R14D	Divided	Ranked	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	High confidence	322	253	1.27273
	RAB11FIP3		Measured	eferin. [swissprot;acc:o75154]	Low confidence	7407.56	8696.7	1.17403
	SLC25A43		Squared	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	High confidence	106226	192141	1.80879
	SMPD2	Subtracted	Ranked	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Low confidence	234.802	260.98	26.178
40	no value		Rooted	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	High confidence	26.0288	43.1914	17.1626
	ATG4A	Divided	Squared	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]		144940	81169.7	1.78564
	CPSF2	Subtracted		cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]		222655	143584	79071
	DTX2		Ranked	deltex 2. [refseq;acc:nm_020892]		333.144	267.393	65.751
	FCN2	Divided		ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]		322	253	1.27273
	FOSB	Subtracted	Rooted	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Low confidence	66.6504	75.3798	8.7294
	FOSL2	Divided	Measured	fos-related antigen 2. [swissprot;acc:p15408]		6480.59	7600.25	1.17277
	GNAI1			guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	High confidence	1836.81	907.978	2.02297
			Rooted			40.2797	24.3705	1.65281
	MAGEA6	Subtracted	Squared	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Low confidence	82347.8	61881.5	20466.3
	MAGEA9	Divided		melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]				1.33073
	MAGED2	Subtracted	Measured	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	High confidence	23693.7	18263	5430.7
	OSBPL6			oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Low confidence	736.5	2113.5	1377
	PPP1R14A	Divided	Rooted	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]		55.7075	63.2842	1.13601
	SON		Ranked	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]		255.382	223.538	1.14245
	TMEM33	Subtracted		db83 protein. [swissprot;acc:p57088]		234.802	260.98	26.178
41	no value	Divided		protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	High confidence	322	253	1.27273
	DTX1	Subtracted		deltex homolog 1; hdx-1. [refseq;acc:nm_004416]		332.925	267.274	65.651
	FIP1L1		Squared	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]		214143	138337	75806
	FOS		Rooted	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]		60.8365	77.7233	16.8868
	FOSB	Divided	Measured	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Low confidence	6481.62	7600.61	1.17264
	FOSL1	Subtracted	Rooted	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]		66.6623	75.3751	8.7128
	GNAI3	Divided	Measured	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	High confidence	1836.81	907.978	2.02297
			Rooted			40.2797	24.3705	1.65281
	GSTO2		Ranked	ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5]	Low confidence	228.147	200.55	1.13761
	MAGEA8		Squared	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]		82347.8	61881.5	1.33073

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.