MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	Value Type	description	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1 to 50 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	Interaction Map	red	green	network_comparison
1	CPD	Divided	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Low confidence	16	32	2
	HLX	Subtracted	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	High confidence	215	322	107
	LAMP1		lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Low confidence	223	330
	UBAC1	Divided	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	High confidence	10	24	2.4
2	no value		mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		15	28	1.86667
	CDK4	Subtracted	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Low confidence	223	330	107
	HBS1L		hbs1-like. [refseq;acc:nm_006620]	High confidence	215	322
	LAMP1	Divided	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Low confidence	223	330	1.47982
3	CDK4		cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]
	CDK6	Subtracted	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]				107
	PSCD1	Divided	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	High confidence	15	28	1.86667
	RINT1	Subtracted	rad50-interacting protein 1. [refseq;acc:nm_021930]		337	232	105
4	CDK6	Divided	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Low confidence	223	330	1.47982
	LAMP2	Subtracted	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]				107
	PSCD2	Divided	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	High confidence	15	28	1.86667
	RHOBTB2	Subtracted	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]		337	232	105
5	LAMP2	Divided	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Low confidence	223	330	1.47982
	OSBPL6	Subtracted	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]		318	240	78
	PSCD4	Divided	cytohesin 4. [swissprot;acc:q9uia0]	High confidence	15	28	1.86667
	XAB1	Subtracted	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]		212	309	97
6	ATPBD1C		protein x 0004. [refseq;acc:nm_016301]
	OSBPL3		oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Low confidence	318	240	78
	OSBPL6	Divided	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]				1.325
	PSCD3		cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	High confidence	15	28	1.86667
7	HLX		homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		215	322	1.49767
	OSBPL3		oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Low confidence	318	240	1.325
	OSBPL7	Subtracted	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]				78
	UFC1		protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	High confidence	288.754	212.554	76.2
8	HBS1L	Divided	hbs1-like. [refseq;acc:nm_006620]		215	322	1.49767
	JMJD1C	Subtracted	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	Low confidence	305.472	247.246	58.226
	JPH3		junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	High confidence	288	362	74
	OSBPL7	Divided	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	Low confidence	318	240	1.325
9	JPH2	Subtracted	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	High confidence	288	362	74
	MRPS17	Divided	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Low confidence	58	44	1.31818
	TMEM132A	Subtracted	gbp protein isoform a. [refseq;acc:nm_017870]		305.399	247.213	58.186
	XAB1	Divided	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	High confidence	212	309	1.45755
10	ATPBD1C		protein x 0004. [refseq;acc:nm_016301]
	JMJD1A	Subtracted	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	Low confidence	305.303	247.169	58.134
	SLC25A43	Divided	mitochondrial solute carrier protein. [refseq;acc:nm_145305]		58	44	1.31818
	SMPD2	Subtracted	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	High confidence	288	362	74
11	BEST1	Divided	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	Low confidence	37.318	28.4944	1.30966
	PRSS3	Subtracted	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]		304.548	246.824	57.724
	RINT1	Divided	rad50-interacting protein 1. [refseq;acc:nm_021930]	High confidence	337	232	1.45259
	TMEM33	Subtracted	db83 protein. [swissprot;acc:p57088]		288	362	74
12	no value		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]		266.856	336.233	69.377
	BEST4	Divided	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	Low confidence	37.3475	28.5242	1.30933
	PRSS1	Subtracted	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]		304.359	246.737	57.622
	RHOBTB2	Divided	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	High confidence	337	232	1.45259
13	no value		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Low confidence	37.9984	29.1831	1.30207
	GNG12	Subtracted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	High confidence	266.856	336.233	69.377

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.