MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Network Comparison Type	Gene	Value Type	Hugo	Interaction Map	red	Filtered	green	network_comparison

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Showing element 951 to 1000 of 66312 in total

Filtered  : 1

description	Rank	Network Comparison Type	Value Type	Hugo	Interaction Map	red	green	network_comparison
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	3296	Subtracted	Squared	no value	Low confidence	45082.7	43619.2	1463.5
	3343	Divided						1.03355
3-ketoacyl-coa thiolase, peroxisomal precursor (ec 2.3.1.16) (beta- ketothiolase) (acetyl-coa acyltransferase) (peroxisomal 3-oxoacyl- coa thiolase). [swissprot;acc:p09110]	840	Subtracted		ACAA1	High confidence	27235.1	31125.2	3890.1
	1116	Divided						1.14283
	2061	Subtracted	Measured			6946.82	7263.87	317.05
	2300	Divided	Ranked			191.563	192.541	1.00511
	2305		Measured			6946.82	7263.87	1.04564
	2331	Subtracted	Ranked			191.563	192.541	0.978
	2473		Rooted			71.4427	72.2607	0.818
	2490	Divided						1.01145
	2649		Ranked		Low confidence	195.904	192.486	1.01776
	2813	Subtracted						3.418
	3679		Measured			8168.73	8366.35	197.62
	3727		Rooted			73.8081	75.8932	2.0851
	3780	Divided	Measured			8168.73	8366.35	1.02419
	3846	Subtracted	Squared			44613.5	43332.8	1280.7
	3866	Divided	Rooted			73.8081	75.8932	1.02825
	3876		Squared			44613.5	43332.8	1.02955
3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	515			MPST	High confidence	19987.6	23960.7	1.19878
	563		Measured			5480.24	6222.04	1.13536
	615	Subtracted						741.8
	767	Divided	Rooted			63.5181	67.7402	1.06647
	769	Subtracted						4.2221
	805		Squared			19987.6	23960.7	3973.1
	1025	Divided	Ranked			205.632	199.266	1.03195
	1048	Subtracted						6.366
	1727		Measured		Low confidence	8425.53	8689.87	264.34
	2218	Divided						1.03137
	2252		Ranked			196.562	192.92	1.01888
	2290	Subtracted	Rooted			74.3411	76.8115	2.4704
	2394		Ranked			196.562	192.92	3.642
	2644	Divided	Rooted			74.3411	76.8115	1.03323
	4174	Subtracted	Squared			48087	46959.8	1127.2
	4323	Divided						1.024
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	914	Subtracted	Ranked	SRD5A1		204.147	199.196	4.951
	949	Divided						1.02485
	959	Subtracted	Rooted		High confidence	61.6649	65.1892	3.5243
	971	Divided						1.05715
	1040	Subtracted	Ranked			220.118	213.685	6.433
	1083	Divided						1.03011
	1140		Rooted		Low confidence	71.1233	73.8482	1.03831
	1230	Subtracted						2.7249
	1244		Measured		High confidence	5885	6371.14	486.14
	1274	Divided						1.08261
	1626		Squared		Low confidence	45165.2	43316.1	1.04269
	1709	Subtracted						1849.1
	2082	Divided	Measured			7887.47	8138.17	1.03178
	2167	Subtracted						250.7
	2526		Squared		High confidence	28935	30015.7	1080.7
	2609	Divided						1.03735

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.