MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 951 to 1000 of 66312 in total

Filtered  : 1

Rank	Hugo	Value Type	description	Network Comparison Type	Interaction Map	network_comparison	red	green
60	GNG8	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Divided	High confidence	1.25976	266.864	336.184
	HOXD4	Measured	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]		Low confidence	1.13635	15464.1	17572.7
	LENG4	Ranked	malignant cell expression-enhanced gene/tumor progression-enhanc. [refseq;acc:nm_024298]	Subtracted		20.635	211	231.635
	MAGEA6	Squared	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Divided	High confidence	1.68808	219048	129762
	MAGEC1	Rooted	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Subtracted		16.623	137.446	120.823
	PPP1R2	Squared	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]			66737	192904	126167
	PSCD2		cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Divided	Low confidence	1.29425	92930.5	71802.4
	SON	Rooted	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]		High confidence	1.39806	35.6294	49.8119
	TEX28P2		testis-specific protein tex28. [swissprot;acc:o15482]	Subtracted	Low confidence	7.4602	51.7058	59.166
	TP53I3	Measured	tumor protein p53 inducible protein 3; quinone oxidoreductase homolog; p53-induced gene 3 protein. [refseq;acc:nm_004881]			1108.2	11371	12479.2
61	APBA1	Ranked	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]			20.341	229.144	208.803
	ARRB2	Measured	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]		High confidence	3832	6475.5	10307.5
	FOSB	Ranked	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Divided	Low confidence	1.10831	202.792	182.974
	GNG5		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]		High confidence	1.25975	266.864	336.182
	GOSR2	Rooted	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	Subtracted	Low confidence	7.4602	51.7058	59.166
	HOXB5	Measured	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Divided		1.13635	15464.1	17572.7
	JUND		transcription factor jun-d. [swissprot;acc:p17535]	Subtracted		1065.74	6614.51	7680.25
	KCND3	Ranked	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]		High confidence	58.394	269.248	327.642
	KCNIP1	Rooted	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	Divided		1.36932	43.4291	31.7159
	MAGEA4		melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Subtracted		16.623	137.446	120.823
	NCDN	Squared	neurochondrin. [refseq;acc:nm_014284]		Low confidence	16178.9	73677.6	57498.7
	NDN		necdin. [swissprot;acc:q99608]	Divided	High confidence	1.68808	219048	129762
	PPP1R2P9		type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]	Subtracted		66684	192779	126095
	PSCD3		cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Divided	Low confidence	1.29422	92920.4	71796.4
	PYGB	Measured	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]		High confidence	1.6231	4489.19	2765.82
	SMYD2	Rooted	set and mynd domain containing 2; hskm-b protein; zinc finger, mynd domain containing 14. [refseq;acc:nm_020197]		Low confidence	1.11478	59.2532	66.0541
62	no value		melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Subtracted	High confidence	16.623	137.446	120.823
	ARRB1	Measured	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]			3832	6475.5	10307.5
	BACH1	Rooted	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]		Low confidence	7.4298	79.2778	86.7076
	BNC1	Squared	zinc finger protein basonuclin. [swissprot;acc:q01954]			15083.7	105225	90141.3
	FOS	Ranked	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]			20.072	202.802	182.73
	FOSL1		fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	Divided		1.10804	202.79	183.017
	GNG10		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]		High confidence	1.25974	266.865	336.181
	HOXA5	Measured	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]		Low confidence	1.13635	15464.1	17572.7
	JUNB		transcription factor jun-b. [swissprot;acc:p17275]	Subtracted		1065.34	6613.42	7678.76
	KCND1	Ranked	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]		High confidence	58.371	269.23	327.601
	KCNIP4	Rooted	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	Divided		1.36847	43.4519	31.7522
	MAGED1	Squared	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]			1.68808	219048	129762
	PSCD4		cytohesin 4. [swissprot;acc:q9uia0]		Low confidence	1.29219	92262.9	71400.2
	PYGL	Measured	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]		High confidence	1.6231	4489.19	2765.82
	RRS1	Squared	ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050]	Subtracted		65496	189976	124480
	SMYD1	Rooted	set and mynd domain containing protein 1. [sptrembl;acc:q8nb12]	Divided	Low confidence	1.11478	59.2532	66.0541
63	no value	Measured	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]			1.13635	15464.1	17572.7
		Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		High confidence	1.25973	266.865	336.178
			jun dimerization protein. [refseq;acc:nm_130469]	Subtracted	Low confidence	20.072	202.802	182.73
	C1GALT1	Squared	core1 udp-galactose:n-acetylgalactosamine-alpha-r beta 1,3-galac. [refseq;acc:nm_020156]	Divided		1.28138	73677.6	57498.7
	GMPPA		gdp-mannose pyrophosphorylase a; mannose-1-phosphate guanylyltransferase (gdp). [refseq;acc:nm_013335]	Subtracted		14172.1	75927.4	61755.3
	KCNIP2	Rooted	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	Divided	High confidence	1.36835	43.4554	31.7576
	MAGEA10		melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Subtracted		16.623	137.446	120.823
	MAGEF1	Squared	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Divided		1.68808	219048	129762

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.