MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	description	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 944 to 993 of 66312 in total

Filtered  : 1

description	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	red	green	network_comparison
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	1660	no value	Measured	Divided	Low confidence	7966.46	8232.52	1.0334
	1679			Subtracted				266.06
	1852		Ranked	Divided	High confidence	196.008	198.154	1.01095
	1898		Measured			6885.11	7317.48	1.0628
	1914		Ranked	Subtracted		196.008	198.154	2.146
	2369		Rooted			70.3295	71.371	1.0415
	2412			Divided				1.01481
	3296		Squared	Subtracted	Low confidence	45082.7	43619.2	1463.5
	3343			Divided				1.03355
3-ketoacyl-coa thiolase, peroxisomal precursor (ec 2.3.1.16) (beta- ketothiolase) (acetyl-coa acyltransferase) (peroxisomal 3-oxoacyl- coa thiolase). [swissprot;acc:p09110]	840	ACAA1		Subtracted	High confidence	27235.1	31125.2	3890.1
	1116			Divided				1.14283
	2061		Measured	Subtracted		6946.82	7263.87	317.05
	2300		Ranked	Divided		191.563	192.541	1.00511
	2305		Measured			6946.82	7263.87	1.04564
	2331		Ranked	Subtracted		191.563	192.541	0.978
	2473		Rooted			71.4427	72.2607	0.818
	2490			Divided				1.01145
	2649		Ranked		Low confidence	195.904	192.486	1.01776
	2813			Subtracted				3.418
	3679		Measured			8168.73	8366.35	197.62
	3727		Rooted			73.8081	75.8932	2.0851
	3780		Measured	Divided		8168.73	8366.35	1.02419
	3846		Squared	Subtracted		44613.5	43332.8	1280.7
	3866		Rooted	Divided		73.8081	75.8932	1.02825
	3876		Squared			44613.5	43332.8	1.02955
3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	515	MPST			High confidence	19987.6	23960.7	1.19878
	563		Measured			5480.24	6222.04	1.13536
	615			Subtracted				741.8
	767		Rooted	Divided		63.5181	67.7402	1.06647
	769			Subtracted				4.2221
	805		Squared			19987.6	23960.7	3973.1
	1025		Ranked	Divided		205.632	199.266	1.03195
	1048			Subtracted				6.366
	1727		Measured		Low confidence	8425.53	8689.87	264.34
	2218			Divided				1.03137
	2252		Ranked			196.562	192.92	1.01888
	2290		Rooted	Subtracted		74.3411	76.8115	2.4704
	2394		Ranked			196.562	192.92	3.642
	2644		Rooted	Divided		74.3411	76.8115	1.03323
	4174		Squared	Subtracted		48087	46959.8	1127.2
	4323			Divided				1.024
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	914	SRD5A1	Ranked	Subtracted		204.147	199.196	4.951
	949			Divided				1.02485
	959		Rooted	Subtracted	High confidence	61.6649	65.1892	3.5243
	971			Divided				1.05715
	1040		Ranked	Subtracted		220.118	213.685	6.433
	1083			Divided				1.03011
	1140		Rooted		Low confidence	71.1233	73.8482	1.03831
	1230			Subtracted				2.7249
	1244		Measured		High confidence	5885	6371.14	486.14

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.