MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 932 to 981 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Value Type	red	green	network_comparison
233	MYH13	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	Measured	9035	7279.6	1.24114
234	no value	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Rooted	137.446	120.823	1.13758
	CHRAC1	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	Ranked	287.41	256.835	1.11905
	CHRNA6	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	Squared	42411.6	55802.1	1.31573
	RPS6KC1	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	Measured	5181.2	6410.58	1.23728
235	no value	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]
	ISCU	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	Squared	42411.6	55802.1	1.31573
	MAGEA9	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Rooted	137.446	120.823	1.13758
	PAH	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	Ranked	227.357	254.15	1.11785
236	DUS1L	pp3111 protein. [refseq;acc:nm_022156]
	MAGEA8	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Rooted	137.446	120.823	1.13758
	STARD13	star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]	Squared	42411.6	55802.1	1.31573
	TXNL4A	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]	Measured	4723.53	5828.46	1.23392
237	LSM5	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]		4567.04	5631.2	1.23301
	MAGEC1	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Rooted	137.446	120.823	1.13758
	STARD8	star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	Squared	42411.6	55802.1	1.31573
	STX18	syntaxin 18. [swissprot;acc:q9p2w9]	Ranked	227.357	254.15	1.11785
238	no value	rd protein. [swissprot;acc:p18615]
	CHRNA2	neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	Squared	42411.6	55802.1	1.31573
	MAGEA4	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Rooted	137.446	120.823	1.13758
	PPP1R7	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	Measured	27642.5	22440.4	1.23182
239	no value	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Rooted	137.446	120.823	1.13758
	CPA6	carboxypeptidase b precursor. [refseq;acc:nm_020361]	Measured	7711.38	6265.8	1.23071
	GSTO1	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	Ranked	227.357	254.15	1.11785
	MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]	Squared	42411.6	55802.1	1.31573
240	AIG1	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	Ranked	227.357	254.15	1.11785
	CPA3	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	Measured	7711.36	6265.79	1.23071
	MAGEA10	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Rooted	137.446	120.823	1.13758
	MAPK14	mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539]	Squared	42411.6	55802.1	1.31573
241	ATP5F1	atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539]	Ranked	227.357	254.15	1.11785
	CHRNA4	neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681]	Squared	42411.6	55802.1	1.31573
	CPB2	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	Measured	7711.31	6265.76	1.23071
	MAGEB4	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Rooted	137.446	120.823	1.13758
242	CHRNA3	neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297]	Squared	42411.6	55802.1	1.31573
	DNAJC12	j domain containing protein 1. [swissprot;acc:q9ukb3]	Ranked	227.357	254.15	1.11785
	MAGED2	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	Rooted	137.446	120.823	1.13758
	MAX	max protein. [swissprot;acc:p25912]	Measured	4640.26	5704.87	1.22943
243	HOMER2	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]		4246.95	5208.98	1.22652
	SNX13	sorting nexin 13 (rgs domain- and phox domain-containing protein) (rgs-px1). [swissprot;acc:q9y5w8]	Ranked	227.357	254.15	1.11785
	SPHK2	sphingosine kinase 2 (ec 2.7.1.-) (sk 2) (spk 2). [swissprot;acc:q9nra0]	Squared	42411.6	55802.1	1.31573
	TRO	trophinin. [swissprot;acc:q12816]	Rooted	137.446	120.823	1.13758
244	COQ7	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	Measured	4250.14	5211.25	1.22614
	GSTO2	ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5]	Ranked	227.357	254.15	1.11785
	MYO5B	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Rooted	146.94	167.046	1.13683
	NCBP2L	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	Squared	14728.8	19330.8	1.31245
245	GBE1	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]		8875.01	6768.05	1.31131
	HOMER1	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	Measured	4251.65	5212.33	1.22595
	MYO5C	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	Rooted	146.94	167.046	1.13683
	SNRPD3	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	Ranked	226.109	202.333	1.11751
246	no value	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Rooted	146.94	167.046	1.13683

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.