MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 930 to 979 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
465	neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]	CHRNA7	Divided	248.152	267.226	1.07686
466	adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]	ADCY6
	pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]	PRPF31	Subtracted	225.661	209.651	16.01
467	adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	ADCY5	Divided	248.152	267.226	1.07686
	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	DDX31	Subtracted	248.56	232.579	15.981
468	dna-directed rna polymerase ii 7.6 kda polypeptide (ec 2.7.7.6) (rpb10) (rpb7.6) (rpabc5). [swissprot;acc:p52436]	POLR2L		237.627	253.604	15.977
	leucine-rich repeat-containing protein 15 precursor (hlib). [swissprot;acc:q8tf66]	LRRC15	Divided	248.152	267.226	1.07686
469	fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]	FEM1B
	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	KCNA2	Subtracted	226.789	210.818	15.971
470	inhibitor of growth family, member 1; inhibitor of growth 1. [refseq;acc:nm_005537]	ING1		224.535	240.476	15.941
	leucine-rich repeat protein lrrc3 precursor. [swissprot;acc:q9by71]	LRRC3	Divided	248.152	267.226	1.07686
471	laminin gamma-1 chain precursor (laminin b2 chain). [swissprot;acc:p11047]	LAMC1
	zinc finger-like protein 9. [refseq;acc:nm_033414]	ZNF622	Subtracted	250.942	235.004	15.938
472	membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]	SLC45A2
	thymic stromal co-transporter. [refseq;acc:nm_033051]	SLC46A2	Divided	248.152	267.226	1.07686
473	guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]	no value	Subtracted	250.942	235.004	15.938
	pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]	PRPF31	Divided	225.661	209.651	1.07637
474	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]	KCNA1	Subtracted	226.727	210.816	15.911
	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	KCNA2	Divided	226.789	210.818	1.07576
475	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]	KCNA1		226.727	210.816	1.07547
	protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]	MEMO1P	Subtracted	236.964	252.86	15.896
476	potassium voltage-gated channel subfamily a member 4 (potassium channel kv1.4) (hk1) (hpcn2) (hbk4) (hukii). [swissprot;acc:p22459]	KCNA4	Divided	226.681	210.814	1.07527
			Subtracted			15.867
477	rho guanine nucleotide exchange factor 7 (pak-interacting exchange factor beta) (beta-pix) (cool-1) (p85). [swissprot;acc:q14155]	ARHGEF7		220.183	236.015	15.832
	saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101]	NIP7	Divided	251.926	234.547	1.0741
478	serine/threonine-protein kinase pak 2 (ec 2.7.1.-) (p21-activated kinase 2) (pak-2) (pak65) (gamma-pak) (s6/h4 kinase). [swissprot;acc:q13177]	PAK2	Subtracted	220.171	235.979	15.808
	transcription factor iiib 90 kda subunit (tfiiib90) (htfiiib90) (b- related factor 1) (hbrf) (tata box-binding protein-associated factor, rna polymerase iii, subunit 2) (taf3b2). [swissprot;acc:q92994]	BRF1	Divided	228.051	212.321	1.07409
479	conserved oligomeric golgi complex subunit 5 (13s golgi transport complex 90 kda subunit) (gtc-90) (golgi transport complex 1). [swissprot;acc:q9up83]	COG5	Subtracted	220.172	235.98	15.808
	nucleolar protein family a, member 1; gar1 protein. [refseq;acc:nm_018983]	NOLA1	Divided	228.051	212.321	1.07409
480	neuropilin- and tolloid-like protein 2 precursor. [refseq;acc:nm_018092]	NETO2		237.109	254.667	1.07405
	serine/threonine-protein kinase pak 1 (ec 2.7.1.-) (p21-activated kinase 1) (pak-1) (p65-pak) (alpha-pak). [swissprot;acc:q13153]	PAK1	Subtracted	220.172	235.98	15.808
481	neuropilin- and tolloid-like protein 1 isoform 3 precursor. [refseq;acc:nm_138966]	NETO1	Divided	237.109	254.667	1.07405
	serine/threonine-protein kinase pak 3 (ec 2.7.1.-) (p21-activated kinase 3) (pak-3) (beta-pak) (oligophrenin-3). [swissprot;acc:o75914]	PAK3	Subtracted	220.171	235.979	15.808
482	heterogenous nuclear ribonucleoprotein u (hnrnp u) (scaffold attachment factor a) (saf-a). [swissprot;acc:q00839]	HNRNPU	Divided	237.109	254.667	1.07405
	rho guanine nucleotide exchange factor 6 (pak-interacting exchange factor alpha) (alpha-pix) (cool-2). [swissprot;acc:q15052]	ARHGEF6	Subtracted	220.161	235.95	15.789
483	runt-related transcription factor 2 (core-binding factor, alpha 1 subunit) (cbf-alpha 1) (acute myeloid leukemia 3 protein) (oncogene aml-3) (polyomavirus enhancer binding protein 2 alpha a subunit) (pebp2-alpha a) (pea2-alpha a) (sl3-3 enhancer factor 1 alpha a subunit) (sl3/akv core-binding factor alpha a subunit) (osteoblast- specific transcription factor 2) (osf-2). [swissprot;acc:q13950]	RUNX2	Divided	237.109	254.667	1.07405
	transcription factor iiib 90 kda subunit (tfiiib90) (htfiiib90) (b- related factor 1) (hbrf) (tata box-binding protein-associated factor, rna polymerase iii, subunit 2) (taf3b2). [swissprot;acc:q92994]	BRF1	Subtracted	228.051	212.321	15.73
484	e1b-55kda-associated protein 5 isoform a. [refseq;acc:nm_007040]	HNRPUL1	Divided	237.109	254.667	1.07405
	nucleolar protein family a, member 1; gar1 protein. [refseq;acc:nm_018983]	NOLA1	Subtracted	228.051	212.321	15.73
485	60s ribosomal protein l18. [swissprot;acc:q07020]	RPL18	Divided	237.109	254.667	1.07405
	protein phosphatase 2c beta isoform (ec 3.1.3.16) (pp2c-beta). [swissprot;acc:o75688]	PPM1B	Subtracted	231.276	215.627	15.649
486	eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]	EIF6		248.866	233.287	15.579
	mct-1 protein. [refseq;acc:nm_014060]	MCTS1	Divided	226.313	243.03	1.07387
487	malate dehydrogenase, mitochondrial precursor (ec 1.1.1.37). [swissprot;acc:p40926]	MDH2	Subtracted	238.529	254.099	15.57
	mitochondrial ribosomal protein l22. [refseq;acc:nm_014180]	MRPL22	Divided	226.313	243.03	1.07387
488	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	no value	Subtracted	82.5916	98.0548	15.4632
	squamous cell carcinoma antigen recognized by t cells 1; u4/u6.u5 tri-snrnp-associated 110 kda protein; ige autoantigen; sart1(259) protein; sart1(800) protein. [refseq;acc:nm_005146]	SART1	Divided	225.026	209.798	1.07258
489	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	ATG3	Subtracted	82.5916	98.0548	15.4632
	protein phosphatase 2c beta isoform (ec 3.1.3.16) (pp2c-beta). [swissprot;acc:o75688]	PPM1B	Divided	231.276	215.627	1.07257
490	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	SSB	Subtracted	242.531	227.136	15.395

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.