MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 930 to 979 of 66312 in total

Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	red	green	network_comparison
3-hydroxyanthranilate 3,4-dioxygenase (ec 1.13.11.6) (3-hao) (3-hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [swissprot;acc:p46952]	1764	HAAO	Divided	Rooted	High confidence	67.2158	69.3348	1.03153
	1826		Subtracted	Measured		6916.14	7295.24	379.1
	2105		Divided					1.05481
	2189			Ranked		209.54	208.162	1.00662
	2201		Subtracted					1.378
	2541			Squared		35558.6	36579.1	1020.5
	2642		Divided					1.0287
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	544	no value	Subtracted			27898	32866.2	4968.2
	646		Divided					1.17808
	855		Subtracted	Ranked	Low confidence	203.354	198.284	5.07
	879		Divided					1.02557
	1052			Rooted		71.6074	74.3827	1.03876
	1108		Subtracted					2.7753
	1543			Measured	High confidence	6885.11	7317.48	432.37
	1660		Divided		Low confidence	7966.46	8232.52	1.0334
	1679		Subtracted					266.06
	1852		Divided	Ranked	High confidence	196.008	198.154	1.01095
	1898			Measured		6885.11	7317.48	1.0628
	1914		Subtracted	Ranked		196.008	198.154	2.146
	2369			Rooted		70.3295	71.371	1.0415
	2412		Divided					1.01481
	3296		Subtracted	Squared	Low confidence	45082.7	43619.2	1463.5
	3343		Divided					1.03355
3-ketoacyl-coa thiolase, peroxisomal precursor (ec 2.3.1.16) (beta- ketothiolase) (acetyl-coa acyltransferase) (peroxisomal 3-oxoacyl- coa thiolase). [swissprot;acc:p09110]	840	ACAA1	Subtracted		High confidence	27235.1	31125.2	3890.1
	1116		Divided					1.14283
	2061		Subtracted	Measured		6946.82	7263.87	317.05
	2300		Divided	Ranked		191.563	192.541	1.00511
	2305			Measured		6946.82	7263.87	1.04564
	2331		Subtracted	Ranked		191.563	192.541	0.978
	2473			Rooted		71.4427	72.2607	0.818
	2490		Divided					1.01145
	2649			Ranked	Low confidence	195.904	192.486	1.01776
	2813		Subtracted					3.418
	3679			Measured		8168.73	8366.35	197.62
	3727			Rooted		73.8081	75.8932	2.0851
	3780		Divided	Measured		8168.73	8366.35	1.02419
	3846		Subtracted	Squared		44613.5	43332.8	1280.7
	3866		Divided	Rooted		73.8081	75.8932	1.02825
	3876			Squared		44613.5	43332.8	1.02955
3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	515	MPST			High confidence	19987.6	23960.7	1.19878
	563			Measured		5480.24	6222.04	1.13536
	615		Subtracted					741.8
	767		Divided	Rooted		63.5181	67.7402	1.06647
	769		Subtracted					4.2221
	805			Squared		19987.6	23960.7	3973.1
	1025		Divided	Ranked		205.632	199.266	1.03195
	1048		Subtracted					6.366
	1727			Measured	Low confidence	8425.53	8689.87	264.34
	2218		Divided					1.03137
	2252			Ranked		196.562	192.92	1.01888

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.